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Chelating adsorbent for blood purification and preparation method thereof

An adsorbent and chelating technology, which is applied in the field of chelating adsorbent for blood purification and its preparation, can solve the problems of reduced process production efficiency, poor blood compatibility, limitations, etc., and achieve improved adsorption and removal capacity with a simple method , the effect of structural simplification

Active Publication Date: 2018-03-13
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Among the existing adsorbents, the main functional monomers of ion exchange resins commonly used to remove heavy metals are acrylic acid, sulfonic acid benzene, etc., and their preparation methods are simple, but their compatibility with blood is poor, which limits their use.
[0005] In addition, the current adsorbent carrier is mainly microspherical particles, and the adsorption column often needs to install structures such as grids and filters to prevent the adsorbent particles from falling into the human body. Such a structure will reduce the production efficiency of the process

Method used

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  • Chelating adsorbent for blood purification and preparation method thereof
  • Chelating adsorbent for blood purification and preparation method thereof
  • Chelating adsorbent for blood purification and preparation method thereof

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preparation example Construction

[0032] A preparation method of chelating adsorbent for blood purification, including the following steps:

[0033] 1) Immerse the polymer in an organic solvent solution containing vinyl monomers and maleic anhydride for irradiation treatment;

[0034] 2) Remove unreacted monomer, maleic anhydride and organic solvent to obtain adsorbent;

[0035] Among them, the vinyl-containing monomer is selected from styrene, vinyl acetate or vinyl pyrrolidone.

[0036] Preferably, in the above preparation method, the adsorbent prepared in step 2) is further subjected to chloromethylation and amination, and then coupled to an anticoagulant; or the adsorbent prepared in step 2) is further subjected to sulfonation modification Sex.

[0037] Preferably, in the above preparation method, the organic solvent is at least one of acetone and methyl ethyl ketone.

[0038] Preferably, in the above preparation method, the polymer is porous sheet-shaped polyethylene, polyurethane, polycarbonate, microspherical pol...

Embodiment 1

[0047] 1) Take 1g polyethylene sheet (pore size 140um, you can directly use the products on the market), add 2.0wt% vinyl acetate, 2.5wt% maleic anhydride in acetone solution 50mL, use 60 Coγ-ray irradiation dose of 50kGy;

[0048] 2) After soaking and rinsing with acetone and 5% sodium hydroxide, then rinse with injection water.

Embodiment 2

[0050] 1) Take 1g polyethylene sheet (pore size 130um, you can directly use the products on the market), add 2.5wt% styrene, 2.5wt% maleic anhydride in acetone solution 50mL, use 60 Coγ-ray irradiation dose of 30kGy;

[0051] 2) After soaking and rinsing with acetone and 5% sodium hydroxide, then rinse with injection water.

[0052] After testing, the moisture content of the modified board cleaned by injection water was 68%.

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Abstract

The invention discloses a chelating adsorbent for blood purification and a preparation method for the chelating adsorbent. The adsorbent comprises a macromolecular carrier which is grafted with a copolymer of maleic anhydride and styrene, vinyl acetate or vinyl pyrrolidone. According to an adsorbing material, a charge transfer complex can be formed by virtue of maleic anhydride and vinyl monomers and is grafted with a copolymer of maleic anhydride, so that the grafting amount of maleic anhydride is improved to a great extent; after the adsorbing material is hydrolyzed, the hydrophilicity of the adsorbing material can be improved so as to improve the blood compatibility. The maleic anhydride obtained by hydrolysis can be chelated with heavy metal ions in blood to form a relatively stable seven-membered ring structure, so that the selective absorption capacity on the heavy metal ions is improved, and therefore, other electrolyte cations are not greatly influenced while the heavy metal ions are removed from blood.

Description

Technical field [0001] The invention relates to a material for blood purification and a preparation method thereof, in particular to a chelating adsorbent for blood purification and a preparation method thereof. Background technique [0002] Heavy metal poisoning refers to poisoning caused by heavy metal elements or their compounds with a relative atomic mass greater than 65, such as mercury poisoning and lead poisoning. Because heavy metals can make irreversible changes in the structure of proteins, thereby affecting the function of tissues and cells, which in turn affects human health. Especially workers who have been exposed to heavy metals for a long time are prone to chronic poisoning and occupational diseases. In addition, for patients with acute heavy metal poisoning, timely rescue is also necessary. On the basis of conventional drug treatment, combined with hemoabsorption therapy can better remove heavy metal toxins from the patient's body, improve the patient's surviva...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F212/08C08F8/32B01J20/26B01J20/30A61M1/38
Inventor 李设桥姜建明
Owner 佛山市博新生物科技有限公司
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