Blood-glucose-reducing antioxidative granule based on wild guava fruit extract and preparation method thereof

A technology of wild guava fruit and guava fruit, which is applied in the direction of anti-toxic agents, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of insufficient development and utilization of wild guava fruit, delay tissue and organ damage, promote Insulin secretion and the effect of improving the extraction rate

Inactive Publication Date: 2015-11-11
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problem of insufficient development and utilization of the existing wild guava fruit, the present...

Method used

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  • Blood-glucose-reducing antioxidative granule based on wild guava fruit extract and preparation method thereof
  • Blood-glucose-reducing antioxidative granule based on wild guava fruit extract and preparation method thereof
  • Blood-glucose-reducing antioxidative granule based on wild guava fruit extract and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] In this embodiment, the wild guava produced in Huaping County, Lijiang City, Yunnan Province is used as raw material, and the granules are prepared according to the following steps:

[0028] Ripe wild guava fruit is cut into fruit pieces whose length and thickness are 4-5 mm, and dried at 50° C. and 0.07 MPa vacuum to obtain dried fruit pieces. Tween-80 was weighed and prepared into an aqueous solution with a mass percent concentration of 0.05%, and its pH value was adjusted to 5 with hydrochloric acid.

[0029] Weigh the dried fruit slices, add 8 times the weight of the above-mentioned Tween-containing aqueous solution with a pH value of 5, heat up to 30°C, use 28kH, 300W ultrasonic treatment for 20 minutes, and then extract at 30°C for 1 hour. Repeat the above ultrasonic treatment and extraction operation twice, and combine the extracts. Concentrate the extract solution at 50°C and 0.07MPa vacuum to obtain the wild guava fruit extract to a mass equivalent to 0.8g / mL ...

Embodiment 2

[0033] In this embodiment, the wild guava produced in Miyi County, Panzhihua City, Sichuan Province is used as raw material, and the granules are prepared according to the following steps:

[0034] Ripe wild guava fruit is cut into fruit pieces whose length and thickness are 4-5 mm, and dried at 50° C. and 0.07 MPa vacuum to obtain dried fruit pieces. Weigh sodium lauryl sulfate, prepare an aqueous solution with a concentration of 0.1% by mass, and adjust its pH value to 3 with hydrochloric acid.

[0035] Weigh the dried fruit slices, add 8 times the weight of the above-mentioned aqueous solution containing sodium lauryl sulfate with a pH value of 3, heat up to 50°C, use 28kH, 300W ultrasonic treatment for 20 minutes, and then extract at 50°C for 1 hour. Repeat the above ultrasonic treatment and extraction operation twice, and combine the extracts. Concentrate the extract solution at 50°C and 0.07MPa vacuum to obtain the wild guava fruit extract to a mass equivalent to 1.2 g / ...

Embodiment 3

[0039] In this example, the wild guava produced in Yongsheng County, Lijiang City, Yunnan Province was used as raw material, and the granules were prepared according to the following steps:

[0040] Ripe wild guava fruit is cut into fruit pieces whose length and thickness are 4-5 mm, and dried at 50° C. and 0.07 MPa vacuum to obtain dried fruit pieces. Weigh sodium lauryl sulfate and sucrose fatty acid ester to prepare a mixed aqueous solution with a mass percent concentration of 0.05%, and adjust its pH value to 4 with hydrochloric acid.

[0041] Weigh the dried fruit slices, add 8 times the weight of the above-mentioned aqueous solution containing sodium lauryl sulfate and sucrose fatty acid ester with a pH value of 4, heat up to 40°C, use 28kH, 300W ultrasonic treatment for 20 minutes, and then heat it at 40°C Extract for 1 hour. Repeat the above ultrasonic treatment and extraction operation twice, and combine the extracts. Concentrate the extract at 50°C and 0.07MPa vacu...

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Abstract

The invention discloses a blood-glucose-reducing antioxidative granule based on wild guava fruit extract and a preparation method thereof. The granule comprises, by weight, 2 parts of the wild guava fruit extract, 1 to 2.5 parts of a filler and 0.3 to 0.8 part of a binder. After gavage with the granule for 40 d, fasting blood glucose of mice with alloxan-induced diabetes returns to a value below the normal value 7 mmol/L, and activity of superoxide dismutase in serum of the mice is improved. The granule is prepared through ultrasonic treatment, aided warm water extraction of surface active substances, preparation of blood-glucose-reducing antioxidative active extract and controlling reasonable parameters. The granule further comprises abundant protein and polysaccharide and can prevent hypoglycemic response. Moreover, the granule has the advantages of high efficiency, small usage amount, capacity of overcoming the problems of low utilization rate and poor efficacy of dried guava slice tea and multiple functions like blood glucose reduction, antioxidation and nutritional support, and provides a novel option for adjunctive treatment of patients with diabetes and for nutrition and health.

Description

technical field [0001] The invention belongs to the technical field of granules and preparation thereof, and in particular relates to a hypoglycemic and anti-oxidation granule based on wild guava fruit extract and a preparation method thereof. Background technique [0002] Diabetes is a disease characterized by hyperglycemia, often accompanied by acute and chronic complications of the eyes, kidneys, and cardiovascular organs. The use of Western medicine to treat diabetes has a remarkable effect in lowering blood sugar, but it often causes some adverse reactions, such as hypoglycemia, liver and kidney damage, and the like. In addition, the price of western medicine is high, and the financial burden on patients is heavy. Using Chinese herbal medicine to treat diabetes can reduce blood sugar mildly and persistently, with few side effects, and can effectively delay the occurrence and development of complications through anti-oxidation. In recent years, screening natural active...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/16A61P3/10A61P39/06
Inventor 龚英陈继平严鸿车玮
Owner YUNNAN NORMAL UNIV
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