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Marine drug for adjuvant treatment of Lewis lung carcinoma

A technology for adjuvant therapy and lung cancer, which is applied in drug combinations, antitumor drugs, pharmaceutical formulations, etc., can solve the problems of poor stability of salina β-carotene, poor antitumor efficacy, and complex preparation processes, and achieves improved solubility and Bioavailability, improving antitumor effect, high biological activity effect

Inactive Publication Date: 2015-11-04
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a marine drug for auxiliary treatment of LEWIS lung cancer, which solves the problems of poor stability, low activity and complicated preparation process of existing salina β-carotene products, and is effective for non-small cell lung cancer after compatibility with cisplatin The synergistic and detoxifying effect of platinum-based drugs solves the problems of poor anti-tumor efficacy, high cost and high toxicity of platinum-based drugs

Method used

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  • Marine drug for adjuvant treatment of Lewis lung carcinoma
  • Marine drug for adjuvant treatment of Lewis lung carcinoma
  • Marine drug for adjuvant treatment of Lewis lung carcinoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Selection of Different Excipients for Preparation of Dropping Pills

[0040] According to the principle of the drop pill preparation process, eight schemes were designed for the proportioning of auxiliary materials and the temperature of the condensate, as shown in Table 1.

[0041] Table 1 Screening of excipient ratio scheme

[0042] Accessories

Ⅰ

Ⅱ

Ⅲ

Ⅳ

Ⅴ

Ⅵ

Ⅶ

Ⅷ

Polyethylene glycol-6000

5g

5g

4g

4.5g

5g

—

—

—

Polyethylene glycol-4000

—

—

—

—

—

5g

4.5g

4g

Polyethylene glycol-1500

2.5g

—

3.5g

3g

2.5g

—

3g

3.5g

Condensate temperature

11℃

4℃

6℃

6℃

4℃

4℃

4℃

4℃

[0043] Heat and melt polyethylene glycol-6000 and / or polyethylene glycol-1500 on a 95°C water bath, stir evenly, and drop them into a container containing 4 or 11°C simethicone oil at 95°C. After molding Take it out...

Embodiment 2

[0056] The preparation of Salina β-carotene dripping pills: comprises the following steps,

[0057] Heat polyethylene glycol-6000 and polyethylene glycol-1500 on a water bath at 95°C to melt, stir evenly, then add salina β-carotene extract and sodium bisulfite, stir well, and mix evenly , drop into a container containing 4-6°C simethicone oil at 95°C, take it out after molding, and finally wipe off the adsorbed simethicone oil with absorbent paper to obtain salina β-carotene dropping pills.

[0058] According to the three ratios of the prescriptions 1 to 3 in Example 1, the salina β-carotene dropping pills were prepared, and the prepared salina β-carotene dropping pills were respectively dropping pills A, dropping pills B and dropping pills c. The specification of the prepared dropping pills is 30 mg / pill, and the content of Salina β-carotene extract in each pill is 5 mg / pill.

[0059] The method for preparing drop pills with different contents of salina β-carotene extract i...

Embodiment 3

[0062] A marine drug for adjuvant treatment of LEWIS lung cancer, including cisplatin and Salina β-carotene extract, the weight ratio of cisplatin and Salina β-carotene extract is 3:25-100, Salina β-carotene The carotene extract adopts Salina β-carotene dripping pills A or B prepared in Example 2 to prepare the medicine, specifically add the following table:

[0063] Drug A: 30mg cisplatin + 250mg salina β-carotene dropping pill A;

[0064] Drug B: 30mg cisplatin + 500mg salina β-carotene dropping pill A;

[0065] Drug C: 30mg cisplatin + 1000mg salina β-carotene dropping pill A;

[0066] Other contents of the drug can be prepared according to the method described above.

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Abstract

The present invention relates to a marine drug for adjuvant treatment of Lewis lung carcinoma, the marine drug includes cisplatin and a dunaliella salina beta-carotene extract, the weight ratio of cisplatin and dunaliella salina beta-carotene extract is 3: 25-100, the content by weight of a cis-isomer in the dunaliella salina beta-carotene extract is greater than 50%, and the dunaliella salina beta-carotene extract uses a dunaliella salina beta-carotene extract dropping pill. The content by weight of the cis-isomer in the dunaliella salina beta-carotene extract used in the marine drug for adjuvant treatment of Lewis lung carcinoma is greater than 50%, the dunaliella salina beta-carotene anti-tumor effect can be effectively improved, and the toxicity is reduced. The marine drug uses the cisplatin and the dunaliella salina beta-carotene extract together for synergically resisting Lewis lung carcinoma, can effectively improve the anti-tumor effect, and reduces the toxicity of platinum drugs.

Description

technical field [0001] The invention relates to a new preparation and application of salina β-carotene, especially a marine medicine for adjuvant treatment of LEWIS lung cancer. Background technique [0002] As a food additive and nutritional supplement, β-carotene has been recommended by the Food and Agriculture Organization of the United Nations and the World Health Organization Joint Expert Committee on Food Additives, and has been identified as a high-quality nutritional pigment of Class A. The demand for β-carotene in the world is increasing at a rate of 7% to 9% every year. Because the β-carotene synthesized by chemical methods is an all-trans isomer, it cannot be completely absorbed by the human body, and has a certain degree of toxic and side effects on the human body. Long-term use will also cause irreversible lesions to the human body, so it is not accepted Accepted by most food scientists, it has been banned as a food additive in western developed countries. Nat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K47/34A61K9/20A61P35/00A61K31/015
Inventor 王春波高慧张磊姜启晓韩彦弢
Owner QINGDAO UNIV
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