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A rat behavior infrared recognition system and its use method and application

A recognition system, infrared technology, applied in applications, medical science, sensors, etc., can solve the problems of affecting rats' emotions, great interference of EEG signals, and large area of ​​shielding devices, so as to avoid chewing to interfere with EEG signals, The effect of saving experimental operation time and facilitating flexible movement

Inactive Publication Date: 2017-11-10
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the existing quantification experiment of rat behavior, what generally use is an electric drive treadmill, by controlling the rotation rate of the electric drive treadmill, the running rate of the rat is controlled, but the electric drive treadmill has the following drawbacks, one is the electric drive treadmill. Drive the treadmill to generate a certain electromagnetic field. The EEG signal of the rat is very weak, generally at the microvolt level. This electromagnetic field will have a serious impact on the EEG signal of the rat, resulting in the inability to accurately detect and analyze the EEG signal; It is necessary to add an additional shielding device, but the shielding device occupies a large area, is inconvenient to use and is expensive
[0003] Most of the existing behavioral experiments use food to induce the formation of conditioned reflexes to make rats move, but this method has obvious disadvantages. First, the rats need to be starved for a long time before the experiment, and their physical fitness will decline. Some rats even In a sick state, it affects the EEG signal; second, the state of hunger will affect the emotion of the rat, and some studies have shown that the emotion affects the EEG signal; third, it is unable to flexibly control the continuous movement of the rat, and it is difficult to collect the brain data of the rat in the continuous movement state. Electrical signals; Fourth, the rats chewed while running, chewing greatly interfered with the EEG signals, and subsequent analysis could not be performed
[0004] Existing treadmill devices seldom have devices for synchronously marking specific behaviors of rats, which can only be marked by naked eyes or camera devices. However, due to the delay of operation after naked eye observation or camera equipment, the marking is inaccurate and synchronous marking cannot be achieved. It is difficult to identify the EEG signals corresponding to specific behaviors in rats
[0005] In addition, in the existing behavioral experiments, the evaluation of rat motor deficit symptoms only has one index of exercise time, which cannot be accurately and comprehensively quantified, and lacks a relatively complete quantitative evaluation method for rat behavior

Method used

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  • A rat behavior infrared recognition system and its use method and application
  • A rat behavior infrared recognition system and its use method and application
  • A rat behavior infrared recognition system and its use method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The method that uses described rat behavior infrared recognition system to carry out experiment, comprises the steps:

[0047]1) train Parkinson's syndrome rats, make the rats form the conditioned reflex of running continuously on the treadmill;

[0048] The experimenter performed uniform rotation treadmill training, the speed of the treadmill was 12r / min, the experimenter visually watched the stopwatch, held the rotating rod, and rotated 1 circle at a constant speed every 5s, and continued to rotate for 30 minutes; the rats were trained to move continuously, and the treadmill was controlled to move upwards. The direction of the head of the rat was rotated. Because of fear, the rat turned around and ran quickly. After several times of training, the rat eliminated the fear, formed a conditioned reflex, and ran continuously on the treadmill.

[0049] 2) When the rats run continuously on the treadmill, observe the behavior of the rats (extend the forelimbs), and write down...

Embodiment 2

[0053] The experimental process is the same as that in Example 1, but the experimental rats are changed to rats with epilepsy. Control the speed of the treadmill to be 12r / min.

[0054] Let the rats run continuously on the treadmill, and measure the relationship between the mistakes of the rats and the EEG signals of the rats. Mistakes refer to the rats falling from the treadmill due to their loss of control within 30 minutes. T max >30min is considered successful. By analyzing the marked position and the EEG signal of the rat at the corresponding position, we can know what the EEG signal is like when the rat with epilepsy makes a mistake.

Embodiment 3

[0056] Application in the establishment of a behavioral quantitative evaluation system for Parkinson's disease rats.

[0057] 1. Materials and methods

[0058] 1. Experimental animals and main instruments

[0059] Healthy adult male Wistar rats, weighing 280-310 g, were provided by the Experimental Animal Center of Shandong University. Behavior tests confirmed no abnormal behavior, and the rats were randomly divided into 2 groups: 8 rats in the normal group and 10 rats in the experimental group. The breeding environment is well ventilated, the humidity is controlled at 45% to 65%, the temperature is maintained at 21°C to 27°C, the day and night are alternated between light and dark for 12 hours, free drinking water, and standard feed.

[0060] Scalp recording electrodes, self-made treadmill (including infrared detector), SPSS 16.0 analysis software, Plexon signal acquisition system, the signal acquisition system consists of adapter, Headstage, high impedance input line, ampl...

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PUM

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Abstract

The invention discloses a rat behavior infrared recognition system and its use method and application, including a recording display, a treadmill, a signal acquisition system, several infrared detectors and a device for reading rat brain electrical signals, wherein, A number of infrared detectors were installed corresponding to the place where the rat’s behavior occurred; all infrared detectors and the device for reading the rat’s EEG signal were connected to the signal acquisition system, which was connected to the recording display, and the rat’s Specific behaviors of the rats were simultaneously recorded in the EEG signals of the rats. The infrared detector cooperates with the signal acquisition system to detect the speed of the treadmill and the specific movement behavior of the rat, and record it in the EEG signal synchronously in the form of an "event", which is used to analyze the EEG under the specific movement behavior of the rat. Signal changes.

Description

technical field [0001] The invention relates to a rat behavior infrared recognition system and its using method and application. Background technique [0002] In the existing quantification experiment of rat behavior, what generally use is an electric drive treadmill, by controlling the rotation rate of the electric drive treadmill, the running rate of the rat is controlled, but the electric drive treadmill has the following drawbacks, one is the electric drive treadmill. Drive the treadmill to generate a certain electromagnetic field. The EEG signal of the rat is very weak, generally at the microvolt level. This electromagnetic field will have a serious impact on the EEG signal of the rat, resulting in the inability to accurately detect and analyze the EEG signal; It is necessary to add an additional shielding device, but the shielding device occupies a large area, is inconvenient to use and is expensive. [0003] Most of the existing behavioral experiments use food to ind...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/11
Inventor 王敏曲庆洋杨茂全张晓谢金鹿耿希文何婷婷
Owner SHANDONG NORMAL UNIV
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