Coumarin compounds, and preparation method and application thereof

Abstract

The invention discloses coumarin compounds. The preparation method comprises the following steps: extracting from rattan of Derris eriocarpa How by the inventor; according to the detection introduction of thin-layer chromatography, carrying out reversed-phase silica gel column chromatography, carrying out gradient elution by a petroleum ether-ethyl acetate system for further systematic separation, and recrystallizing. The antioxidation activity experiment proves that the compounds 1 have favorable antioxidation actions, the IC50 value for superoxide anion removal activity is less than that of the positive drug control ascorbic acid, the IC50 value DPPH.free radical removal activity has no great difference from the positive drug, and the compounds 1 have excellent antioxidation activity as compared with the coumarin compounds 6,7-dihydroxycoumarin, daphnetin and daphnoretin which are reported in documents. Therefore, the coumarin compounds disclosed by the invention can be used as a pharmaceutical or non-pharmaceutical antioxidant and the like.

Description

technical field [0001] The invention belongs to the technical field of new compounds, and in particular relates to a coumarin compound and its preparation method and application. Background technique [0002] Derris eriocarpa How is the dried root and vine of the leguminous plant Derris eriocarpa How, also known as "Spatholobus Spatholobus" and "Licorice vine" etc. It is distributed in Guangxi and Yunnan. Its roots and stems are used as medicine; the stems are brownish yellow, with many xanthoma-like protrusions, and the cross-section is light yellow and fibrous. Deerwort trichome has diuretic and dehumidifying effects, antitussive and phlegm-relieving effects, and is often used in Guangxi Zhuang folk prescriptions, such as treating cystitis, nephritis, urethritis, cough and other symptoms. Because of its remarkable curative effect of folk medicine, it has attracted the attention of more and more researchers. [0003] Free radicals are intermediate metabolites of various b...

AI Technical Summary

Problems solved by technology

At present, the research on the cane of pichocarpus includes resource investigation, identification of medicinal material properties, thin layer, and ultraviolet spectrum, and research on pharmacology and toxicology such as anti-inflammatory and analgesic, cough and expectorant, and its extraction process, biological There are very few studies on the activity, chemical composition, etc., and the research on the extraction process and antioxidant effect of its coumarin compounds has not been reported.

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