Zirconium dioxide composite nanometer material with microwave sensitization, chemotherapy dry release and CT imaging functions and preparation method and application thereof
A composite nanomaterial and zirconium dioxide technology, applied in the field of zirconium dioxide composite nanomaterials and preparation, can solve the problems of no chemotherapeutic function, few tumor chemotherapeutic effects and mechanisms, and achieve good clinical application value and good microwave enhancement. Sensitivity, improve the efficiency of diagnosis and treatment
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Embodiment 1
[0034](1) Disperse Huaier polysaccharide in a mixed solution of deionized water and absolute ethanol (volume ratio 1:1), with a mass volume fraction of 1%, and disperse evenly by ultrasonication or stirring;
[0035] (2) Add hollow zirconia composite nanomaterials to the Huaier polysaccharide aqueous solution obtained in step 1), the concentration is 5 mg mL -1 , realize Huaier polysaccharide encapsulation by negative pressure filling method;
[0036] (3) Wash the hollow zirconia composite nanomaterial wrapped with Huaier polysaccharide obtained in step 2) with deionized water until the supernatant is clear and transparent, that is, it has the functions of microwave sensitization, slow and controlled release of chemotherapeutic drugs, and CT imaging. Hollow zirconia composite nanomaterials coated with Huaier polysaccharide.
[0037] From Figure 1-3 It can be clearly observed that the obtained hollow zirconia composite nanomaterials are uniformly distributed, the particle si...
Embodiment 2
[0043] (1) Disperse Huaier polysaccharide in a mixture of deionized water and 1,4-dioxane (volume ratio 1:1), with a mass volume fraction of 10%, and disperse evenly by ultrasonication or stirring;
[0044] (2) Add hollow zirconia composite nanomaterials to the Huaier polysaccharide aqueous solution obtained in step 1), and the concentration is 10mg mL -1 , realize Huaier polysaccharide encapsulation by negative pressure filling method;
[0045] (3) Wash the hollow zirconia composite nanomaterial wrapped with Huaier polysaccharide obtained in step 2) with deionized water until the supernatant is clear and transparent, that is, it has the functions of microwave sensitization, slow and controlled release of chemotherapeutic drugs, and CT imaging. Hollow zirconia composite nanomaterials coated with Huaier polysaccharide.
[0046] The hollow zirconia composite nanomaterial coated with Huaier polysaccharide prepared in this example was used in microwave hyperthermia technology for...
Embodiment 3
[0051] (1) Disperse Huaier polysaccharide in deionized water with a mass volume fraction of 30%, and disperse evenly by ultrasonication or stirring;
[0052] (2) Add hollow zirconia composite nanomaterials to the Huaier polysaccharide aqueous solution obtained in step 1), and the concentration is 100mg mL -1 , realize Huaier polysaccharide encapsulation by negative pressure filling method;
[0053] (3) Wash the hollow zirconia composite nanomaterial wrapped with Huaier polysaccharide obtained in step 2) with deionized water until the supernatant is clear and transparent, that is, it has the functions of microwave sensitization, slow and controlled release of chemotherapeutic drugs, and CT imaging. Hollow zirconia composite nanomaterials coated with Huaier polysaccharide.
[0054] The hollow zirconia composite nanomaterial coated with Huaier polysaccharide prepared in this example was used in microwave hyperthermia technology for tumors. The in vitro and in vivo microwave heat...
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