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Polycaprolactone-collagen-fibroin nano three-dimensional porous stent and preparation method thereof

A polycaprolactone, three-dimensional porous technology, applied in the direction of conjugated synthetic polymer rayon, cellulose/protein conjugated rayon, fiber treatment, etc., can solve the problems of difficult industrialization, poor mechanical properties, and inability to regulation and other issues

Inactive Publication Date: 2015-09-02
SHANGHAI TONGJI HOSPITAL
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Problems solved by technology

[0003] The present invention provides a polycaprolactone-collagen-silk protein nano three-dimensional porous scaffold and its preparation method, which solves the technical problems that conventional tissue engineering scaffolds in the prior art have poor mechanical properties, cannot be regulated, and are difficult to form industrialization

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  • Polycaprolactone-collagen-fibroin nano three-dimensional porous stent and preparation method thereof
  • Polycaprolactone-collagen-fibroin nano three-dimensional porous stent and preparation method thereof
  • Polycaprolactone-collagen-fibroin nano three-dimensional porous stent and preparation method thereof

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[0018] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0019] The embodiment of the present invention provides a preparation method of polycaprolactone-collagen-silk protein nano three-dimensional porous scaffold, such as figure 1 shown, including:

[0020] Step 101, mulberry silk waste is dissolved in 0.1% Na 2 CO 3 In the aqueous solution, boil repeatedly for half an hour to extract silk fibroin;

[0021] Step 102, dissolving silk fibroin with a ternary solution at high temperature, and drying it at room temperature after dialysis and filtration to form a regenerated silk film;

[0022] Wherein, the ternary solution is CaCl 2 、H 2 O, C 2 h 5 The mixed solution of OH; the mass ratio of the regenerated silk film, water-soluble collagen and polycaprolactone can be 1: 1: 4, 1: 1:...

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Abstract

The invention relates to the field of the preparation of urethral stents, and discloses a polycaprolactone-collagen-fibroin nano three-dimensional porous stent and a preparation method thereof. The preparation method comprises the following steps of dissolving waste mulberry silk in a 0.1 percent of Na2CO3 aqueous solution, and repeatedly boiling for half an hour, so as to extract silk fibroin; dissolving the silk fibroin at a high temperature by using a ternary solution, dialyzing and filtering, and then putting at a room temperature for drying to form a regenerated silk fibroin membrane; dissolving the regenerated silk fibroin membrane, water-soluble collagen and polycaprolactone in hexafluoroisopropanol together, so as to form a mixed solution; carrying out electrostatic spinning on the mixed solution through a rotary receiving device, so as to obtain the nano three-dimensional porous stent, wherein a rotation speed is 300 to 500 revolutions per minute, and the diameter of a rotating shaft is 2 to 6 millimeters. The stent provided by the invention is convenient and efficient to process and manufacture, is convenient to apply, moreover, is convenient for adjusting various performances of a material, is stale in structure, and has certain mechanical strength to support the growth of a fresh tissue.

Description

technical field [0001] The invention relates to the field of preparation of urethral stents, in particular to a polycaprolactone-collagen-silk protein nanometer three-dimensional porous stent and a preparation method thereof. Background technique [0002] Over the past two decades, with the development of tissue engineering technology, urethral reconstruction has entered a new stage. The application of tissue engineering technology in urethral reconstruction has become more and more mature after the initial replacement of simple biological scaffolds to the composite of seed cells and scaffolds. The existing technology uses a natural extracellular matrix (ECM) framework, which has better biocompatibility and has been used in various experimental studies, but its mechanical properties are poor, cannot be adjusted, and it is difficult to form industrialization Widely used clinically. Contents of the invention [0003] The invention provides a polycaprolactone-collagen-silk ...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/22A61L27/18A61L27/38A61L27/56D01F8/02D01F8/14D01D5/00
Inventor 李超吴登龙徐月敏乐威
Owner SHANGHAI TONGJI HOSPITAL
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