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Preparation method of palmatine and composition thereof and novel medical application

A technology of patulin and a composition, applied in the field of medicine, can solve problems such as senile dementia that have not been seen, and achieve the effects of strong prevention and treatment of senile dementia, strong operability, obvious technical progress and innovation.

Active Publication Date: 2015-09-02
何忠梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But up to now, there is no report on the prevention and treatment of alzheimer's disease with the composition of palmatine extracted from Huangteng and the composition of which is mainly composed of palmatine at home and abroad.

Method used

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  • Preparation method of palmatine and composition thereof and novel medical application
  • Preparation method of palmatine and composition thereof and novel medical application
  • Preparation method of palmatine and composition thereof and novel medical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1 , Extraction and preparation of compositions

[0080] 5kg of the medicinal material of Huangteng is crushed into a coarse powder, extracted 3 times with 70% ethanol containing 2% glacial acetic acid, 2 hours each time, combined the extracts, added 0.2% active carbon of the liquid volume, stirred, filtered, and the filtrate decompressed to recover ethanol Obtain extractum, add water to dissolve, make every 1ml contain 1g medicinal material, centrifuge, take supernatant, pass through D101 macroporous resin, first use 10% ethanol to elute 5 times resin volume, then use 60% ethanol to elute 5 times resin volume , collect the ethanol eluent, recover the solvent, and dry under reduced pressure to obtain the composition of patogen as the main component. The content of palmatine in the composition is

[0081] 78.5%. The content of total alkaloids is 97.8%.

Embodiment 2

[0082] Example 2 , the preparation of palmatine

[0083] Take 100 mg of the composition with palmetine as the main component, dissolve it in methanol, pass it through an ODS atmospheric pressure chromatographic column, and use acetonitrile-0.4% phosphoric acid solution (42:68) as the mobile phase to elute, combine the palmetine components, Recrystallization to obtain palmatine.

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Abstract

The invention discloses effects of palmatine and a composition thereof for preventing and treating senile dementia; the palmatine and the composition thereof are extracted from fibraurea recisa pierre of fibraurea lour. of menispermaceae and same generic plants; enzymology and animal experiments prove that both the palmatine and the composition thereof have good effects of preventing and treating senile dementia; further researches show that the activity of the palmatine is better than that of the composition; and the fact shows that the palmatine is a main pharmacodynamic substance.

Description

technical field [0001] The present invention relates to the application of palmatine extracted from yellow vine and plants of the same genus and the composition mainly composed of palmetine in the preparation of medicaments for preventing and treating senile dementia. It also relates to the pharmaceutical preparation of the medicine, and the invention belongs to the technical field of medicine. Background technique [0002] Alzheimer's disease is a progressive brain degenerative disease characterized by progressive memory impairment and intellectual loss, abstract thinking disorder, language disorder, cognitive dysfunction, consciousness disorder, self-care ability and social activity decline or even loss. Its pathogenesis is unclear, and it is a very complex process of neural and cellular aging. Therefore, the prevention and treatment of senile dementia is still a worldwide problem. Current clinical treatment drugs can be divided into anti-β-amyloid deposition drugs, chol...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/4748A61P25/28C07D455/03
Inventor 何忠梅吕娜南敏伦赫玉芳赵昱玮赵全成
Owner 何忠梅
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