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A kind of cetirizine hydrochloride tablet and preparation method thereof

A technology of cetirizine hydrochloride and rizine tablets, which can be applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations with non-active ingredients, and can solve problems such as discomfort and stickiness

Inactive Publication Date: 2017-09-01
张祥坤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cetirizine hydrochloride is highly acidic, and ordinary granulation is often sticky, and if the release is too fast, it is easy to cause side effects such as mild drowsiness, headache, dizziness, dry mouth and gastrointestinal discomfort

Method used

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  • A kind of cetirizine hydrochloride tablet and preparation method thereof
  • A kind of cetirizine hydrochloride tablet and preparation method thereof
  • A kind of cetirizine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021] Preparation Process:

[0022] ① Add cetirizine hydrochloride and mannitol to polystyrene maleic anhydride copolymer and poloxamer 407 in absolute ethanol solution to make soft material, wet granules after sieving with 20 meshes;

[0023] ②Put the wet particles in the shot blasting machine, adjust the rotation speed of the turntable at the bottom of the shot blasting machine to 600rpm, and the blower frequency at 20HZ. The particles are fluidized and rounded in the fluidized bed for about 5 minutes. Lizine pellets;

[0024] ③Coating cetirizine hydrochloride, adding pregelatinized starch and magnesium stearate to the coated cetirizine hydrochloride, mixing and pressing into tablets, no sticking phenomenon occurred.

Embodiment 2

[0026]

[0027] Preparation Process:

[0028] ① Add cetirizine hydrochloride and mannitol to polystyrene maleic anhydride copolymer and poloxamer 407 in absolute ethanol solution to make soft material, wet granules after 40 mesh sieving;

[0029] ②Put the wet particles in the shot blasting machine, adjust the rotating speed of the turntable at the bottom of the shot blasting machine to 900rpm, and the blower frequency at 10HZ. The particles are fluidized and spheronized in the fluidized bed for about 8 minutes. Lizine pellets;

[0030] ③The cetirizine hydrochloride was coated, and the coated cetirizine hydrochloride was added with pregelatinized starch and talcum powder, mixed and pressed into tablets, and no sticking phenomenon occurred.

Embodiment 3

[0032]

[0033]

[0034] Preparation Process:

[0035] ① Add cetirizine hydrochloride and mannitol to polystyrene maleic anhydride copolymer and poloxamer 407 in absolute ethanol solution to make soft material, wet granules after 40 mesh sieving;

[0036] ②Put the wet particles in the shot blasting machine, adjust the rotating speed of the turntable at the bottom of the shot blasting machine to 900rpm, and the blower frequency at 10HZ. The particles are fluidized and spheronized in the fluidized bed for about 8 minutes. Lizine pellets;

[0037] ③The cetirizine hydrochloride was coated, and the coated cetirizine hydrochloride was added with pregelatinized starch and talcum powder, mixed and pressed into tablets, and no sticking phenomenon occurred.

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PUM

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Abstract

The invention discloses a cetirizine hydrochloride tablet and a preparation method thereof, belonging to the field of chemical pharmaceutical preparations. The preparation is made of cetirizine hydrochloride into pellets, which are coated and prepared into tablets. The invention avoids The sticky punch is achieved, and the drug release is stable.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical solid oral preparations, and in particular relates to a cetirizine hydrochloride tablet and a preparation method thereof. Background technique [0002] Levocetirizine hydrochloride tablet is a selective histamine H1 receptor antagonist preparation. As a new type of antihistamine, it is mainly used to relieve allergic symptoms of allergic diseases. It is clinically used to treat allergic rhinitis, urticaria, Skin and mucous membrane allergic diseases such as angioedema have many advantages such as rapid oral absorption, high receptor selectivity, strong clinical efficacy, small side effects, and good safety. It is the first choice for the treatment of allergic diseases. [0003] At present, there are many dosage forms of cetirizine hydrochloride, but mainly in tablets. However, cetirizine hydrochloride is highly acidic, and ordinary granulation is often sticky, and if it is released too qui...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/495A61K9/16A61K47/34A61K47/10A61P37/08A61P11/02A61P17/00A61P9/14A61K47/32
Inventor 张祥坤
Owner 张祥坤
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