Molding mold, and manufacturing method for transdermal absorption sheet

A technology of absorbing sheets and shapes, applied in chemical instruments and methods, medical preparations with non-active ingredients, devices introduced into the body, etc., to achieve the effect of preventing leakage

Inactive Publication Date: 2015-07-15
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, since the needle-shaped recesses of the mold are very small in size, there is a problem that the solution cannot be easily filled into the needle-shaped recesses due to air and surface tension in the casting method.

Method used

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  • Molding mold, and manufacturing method for transdermal absorption sheet
  • Molding mold, and manufacturing method for transdermal absorption sheet
  • Molding mold, and manufacturing method for transdermal absorption sheet

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Embodiment Construction

[0035] Next, the molded article, the percutaneous absorbable sheet and the manufacturing method thereof in the embodiment of the present invention will be described.

[0036] Figure 1A and 1B A perspective view and a cross-sectional view of the pyramid-shaped microneedles of the percutaneous absorption sheet manufactured by the manufacturing method of the present invention are shown in .

[0037] Such as Figure 1A and Figure 1B As shown, in order for the microneedles 22 to penetrate the skin surface at a depth of several hundred μm, for the shape of the microneedles (fine protrusions) 22 formed on the percutaneous absorption sheet, it is necessary that: (1) the front end be sufficiently sharp, The diameter of the needles entering the skin is also sufficiently thin (high aspect ratio of length / diameter); (2) has sufficient strength (the needles will not bend).

[0038] Therefore, in order to meet the requirements of (1), a thin and pointed shape is required, but this is co...

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PUM

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Abstract

A molding mold for forming a transdermal absorption sheet having needle-shaped protrusion parts arrayed thereupon. The molding mold is formed by laminating: a first member, the surface of which has needle-shaped recesses that are the inverse of the needle-shaped protrusions; a second member that is disposed on the rear surface of the first member and comprises waterproof, moisture-permeable materials; and a third member that is disposed on the rear surface of the second member and comprises a rigid body. Thus provided is a molding mold that can prevent the leakage of a medicine-containing liquid that is filled into the needle-shaped recesses, and a transdermal absorption sheet manufacturing method using the molding mold.

Description

technical field [0001] The present invention relates to a molded article for forming a transdermal absorbable sheet in which needle-like protrusions are arranged, and a method for producing the transdermally absorbable sheet. Background technique [0002] Conventionally, as a method of administering drugs or the like from the surface of a living body, that is, the skin or mucous membranes, a method of adhering a liquid substance or a powder substance has been the main method. However, since the adhesion area of ​​these substances is limited to the surface of the skin, the adhered medicines and the like may be removed due to sweating or contact with foreign substances, making it difficult to administer an appropriate amount. In addition, it is difficult to reliably control the depth of penetration in such a method of using penetration by diffusion of the drug in order to allow the drug to penetrate deep into the skin, and thus it is difficult to obtain a sufficient drug effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/70A61K47/36
CPCA61K9/0021A61M2037/0046A61M2037/0053A61M37/0015B29C33/3857B29C33/40B29C33/424A61M2207/10B29C2033/385B29L2031/7544B29L2031/756B32B3/30B32B25/20B32B27/26B32B27/283B32B37/025B32B37/1018B32B2255/26B32B2307/724B32B2307/7265B32B2305/00
Inventor 车彦龙小山田孝嘉吉田淳哉小川正太郎
Owner FUJIFILM CORP
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