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Use of madder in preparation of nitrite scavenging agent

A technology of nitrite and scavenger, which is used in food preparation, medical preparations containing active ingredients, applications, etc.

Inactive Publication Date: 2015-07-15
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on Rubia scavenging in nitrite is blank

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the application of madder scavenging nitrite

[0019] 1. Preparation of Rubia nitrite scavenger

[0020] Collect fresh madder, dry in the shade, ultrasonically extract three times with 75% ethanol for 30 minutes each time, filter, combine the filtrates, evaporate to dryness, and pulverize to make a hard capsule preparation.

[0021] 2. Study on nitrite scavenging activity of madder

[0022] 2.1 Materials and methods

[0023] 2.1.1 Experimental materials

[0024] Raw material: madder nitrite scavenger.

[0025] Reagents: Vc, p-aminobenzenesulfonic acid, naphthaleneethylenediamine hydrochloride, sodium nitrite, disodium hydrogen phosphate, citric acid, ethanol and other reagents are of analytical grade.

[0026] Instruments: electronic balance, vortex mixer, CNC ultrasonic cleaner, automatic microplate reader.

[0027] 2.1.2 Experimental method

[0028] 2.1.2.1 Preparation of the test solution

[0029] Take 5 mg of Rubia nitrite scavenger content, wei...

Embodiment 2

[0045] Embodiment 2: the preparation of madder soft capsule

[0046] Fresh madder was collected, dried in the shade, ultrasonically extracted with ethanol three times for 30 minutes each time, filtered, the filtrates were combined, evaporated to dryness, reconstituted with soybean oil as a sonicated suspension, and made into soft capsules.

Embodiment 3

[0047] Embodiment 3: the preparation of madder tea in bag

[0048] Collect fresh madder, dry in the shade, crush, pass through 40-mesh sieve, 24-mesh sieve, sterilize with ultraviolet light, mechanically bag, pack, print the date, plastic seal, and store.

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PUM

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Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to use of madder in preparation of a nitrite scavenging agent. The nitrite scavenging agent has higher scavenging capability on nitrite and can be further developed to reduce the cancer morbidity of people smoking for a long time (smoking promotes a cancerogenic substance, namely tobacco specific N-nitrite, to be secreted into a bile duct) or other crowds having high nitrite intake, and as a food, a health-care food or a medicament aiming at nitrite poisoning; and the nitrite scavenging capability is far beyond that of vitamin C.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a nitrite scavenger. Background technique [0002] Nitrosamines (NAS) are strong carcinogens for humans and animals, and can generally enter the body through food and drinks. In recent years, gastric cancer, esophageal cancer, nasopharyngeal cancer and bladder cancer have occurred frequently, which are directly related to the content of N-nitroso compounds in the body. Among them, N-dimethylnitrosamine (NDMA) is the most common carcinogenic NAS in food. Dimethylamine (DMA) and nitrite are immediate precursors of carcinogenic NDMA. However, dimethylamine, diethylamine, trimethylamine and trimethylamine oxide are mostly found in fish and marine organisms such as squid and octopus. In food, nitrite exists in almost all pickled products, meat products, pickles and harvested vegetables. Nitrite is also often used as a food preservative. , fish, meat products, egg milk i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P39/02A23L1/30A23L2/38A23L2/39A23L2/52
Inventor 赵岩郜玉钢何忠梅王立岩祝洪艳蔡恩博张连学杨鹤刘双利刘学周
Owner JILIN AGRICULTURAL UNIV
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