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Recycling process of amoxicillin in enzymatically synthesized amoxicillin mother liquor

A technology for amoxicillin mother and amoxicillin, which is applied to the recovery process of amoxicillin in the enzymatic synthesis of amoxicillin mother liquor, and the field of mother liquor recovery technology to achieve the effects of increasing profits, easy post-processing and great economic value

Inactive Publication Date: 2015-07-08
INNER MONGOLIA CHANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no relevant technology to recover the amoxicillin contained in the mother liquor while making the 6-APA contained in the mother liquor participate in the enzyme synthesis reaction and convert it into amoxicillin for recovery, so as to recover the amoxicillin in the mother liquor to the greatest extent. Xilin

Method used

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  • Recycling process of amoxicillin in enzymatically synthesized amoxicillin mother liquor
  • Recycling process of amoxicillin in enzymatically synthesized amoxicillin mother liquor
  • Recycling process of amoxicillin in enzymatically synthesized amoxicillin mother liquor

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Embodiment 1

[0019] Embodiment 1 The recovery process of amoxicillin in the enzymatic synthesis of amoxicillin mother liquor of the present invention

[0020] (1) Take 270L of the mother liquor after the enzymatic synthesis of amoxicillin and the crystallization of amoxicillin, adjust and control the pH of the mother liquor to 6.5 with 10% ammonia water, pour it into the high-power concentration equipment, and make it pass through the nanofiltration membrane for circular concentration , the molecular weight cut-off of the membrane used in nanofiltration is 300 Daltons, the temperature is controlled at 15°C during the concentration process, and the crystallization of the concentrated liquid is observed at any time; when the concentrated mother liquid starts to crystallize, the concentration is stopped, and the final volume of the concentrated liquid is 14L;

[0021] (2) Take 20ml of the concentrated solution of step (1) as a sample, measure the content of L-p-hydroxyphenylglycine, 6-APA, amo...

Embodiment 2

[0030] Embodiment 2 The recovery process of amoxicillin in the enzymatic synthesis of amoxicillin mother liquor of the present invention

[0031] (1) Take 270L of the mother liquor after the enzymatic synthesis of amoxicillin and the crystallization of amoxicillin, adjust and control the pH of the mother liquor to 6.0 with 5% ammonia water, pour it into the high-power concentration equipment, and make it pass through the nanofiltration membrane for circulation and concentration , the molecular weight cut-off of the membrane used in nanofiltration is 150 Daltons, the temperature is controlled at 10°C during the concentration process, and the crystallization of the concentrated liquid is observed at any time; when the concentrated mother liquid starts to crystallize, the concentration is stopped, and the final volume of the concentrated liquid is 20L;

[0032] (2) Take 20ml of the concentrated solution of step (1) as a sample, measure the content of L-p-hydroxyphenylglycine, 6-AP...

Embodiment 3

[0042] Embodiment 3 The recovery process of amoxicillin in the enzymatic synthesis of amoxicillin mother liquor of the present invention

[0043] (1) Take 270L of the mother liquor after enzymatic synthesis of amoxicillin and the crystallization of amoxicillin, adjust and control the pH of the mother liquor to 7.0 with 15% ammonia water, pour it into the high-power concentration equipment, and make it pass through the nanofiltration membrane for circular concentration , the molecular weight cut-off of the membrane used in nanofiltration is 500 Daltons, the temperature is controlled at 20°C during the concentration process, and the crystallization of the concentrated liquid is observed at any time; when the concentrated mother liquid begins to crystallize, the concentration is stopped, and the final concentrated liquid volume is 12L;

[0044] (2) Take 20ml of the concentrated solution of step (1) as a sample, measure the content of L-p-hydroxyphenylglycine, 6-APA, amoxicillin an...

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Abstract

The invention discloses a recycling process of amoxicillin in enzymatically synthesized amoxicillin mother liquor. The process comprises the following steps: concentrating the amoxicillin mother liquor through the adoption of nanofiltration membrane high-power concentration equipment, feeding the concentrated liquor in a reaction tank, sufficiently reacting the 6-APA in the concentrated liquor with methyl D-(-)-4-hydroxy-phenylglycinate under the effect of penicillin G acylase so as to generate the amoxicillin. The recycling process disclosed by the invention has the advantages that through the nanofiltration concentration, not only the amoxicillin in the mother liquor is recycled, but also the 6-APA contained in the mother liquor participates the enzymatic synthesis reaction to be translated into the amoxicillin, the aim of extremely recycling the amoxicillin in the mother liquor is achieved, and the recycling process has more economy.

Description

technical field [0001] The invention relates to a mother liquor recovery process, in particular to a recovery process for amoxicillin in an enzymatically synthesized amoxicillin mother liquor, which belongs to the technical field of pharmacy and the technical field of environmental protection treatment. Background technique [0002] Amoxicillin is one of the most commonly used β-lactam antibiotics with a broad antibacterial spectrum. At present, the synthetic methods of amoxicillin include chemical method and enzymatic method. The chemical synthesis of amoxicillin involves a large amount of organic solvents, which not only endangers human health, but also seriously pollutes the environment. The amoxicillin prepared by the enzymatic process has a high conversion rate and less impurities, avoids the participation of organic solvents in the reaction, and greatly reduces the harm to operators and environmental pollution. In the process of enzymatic synthesis of amoxicillin, al...

Claims

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Application Information

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IPC IPC(8): C12P37/04
Inventor 陈英新韩贺东陈顺记郭建明王继明王秋红刘晓艳
Owner INNER MONGOLIA CHANGSHENG PHARMA
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