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Bioactive glass ceramic and preparation method thereof

A bioactive glass and ceramic technology, applied in the biological field, can solve problems such as general compression resistance, low hardness, and inconsistent density with human bone density

Inactive Publication Date: 2015-07-01
SUZHOU VIVOTIDE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The new type of glass ceramics can replace bone tissue to a certain extent, but it is often affected by various aspects, and has the disadvantages of density inconsistent with human bone density, general compression resistance, and low hardness.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Bioactive glass ceramics, including the following raw materials in parts by weight: 80 parts of sodium oxide, 10 parts of calcium oxide, 4 parts of phosphorus pentoxide, 5 parts of potassium fluoride, 10 parts of potassium oxide, 20 parts of silicon dioxide, 10 parts of zinc oxide 5 parts, 5 parts of polybutylene succinate.

[0015] The particle size of silica is 200 nm.

[0016] The particle diameter of zinc oxide is 400 nm.

[0017] The relative molecular mass of polybutene succinate is 10000.

[0018] The preparation method of the above-mentioned bioactive glass-ceramic comprises the following steps: adding sodium oxide, calcium oxide, phosphorus pentoxide, potassium fluoride, potassium oxide, silicon dioxide, zinc oxide, polybutene succinate into the crucible, Heat at 1400°C for 1 hour, quench to form a frit, and crush it into glass powder with a particle size of 100 microns; melt the glass powder in a crucible at 1000°C, and cool naturally.

Embodiment 2

[0020] Bioactive glass ceramics, including the following raw materials in parts by weight: 100 parts of sodium oxide, 20 parts of calcium oxide, 10 parts of phosphorus pentoxide, 15 parts of potassium fluoride, 15 parts of potassium oxide, 30 parts of silicon dioxide, 40 parts of zinc oxide parts, 9 parts of polybutylene succinate.

[0021] The particle size of silica is 400 nm.

[0022] The particle diameter of zinc oxide is 900 nm.

[0023] The relative molecular mass of polybutene succinate is 60,000.

[0024] The preparation method of the above-mentioned bioactive glass-ceramic comprises the following steps: adding sodium oxide, calcium oxide, phosphorus pentoxide, potassium fluoride, potassium oxide, silicon dioxide, zinc oxide, polybutene succinate into the crucible, Heat at 1800°C for 2 hours, quench to form a frit, and crush it into glass powder with a particle size of 1,000 microns; melt the glass powder in a crucible at 1,200°C, and cool naturally.

Embodiment 3

[0026] Bioactive glass ceramics, including the following raw materials in parts by weight: 90 parts of sodium oxide, 15 parts of calcium oxide, 8 parts of phosphorus pentoxide, 10 parts of potassium fluoride, 12 parts of potassium oxide, 25 parts of silicon dioxide, 30 parts of zinc oxide 7 parts of polybutylene succinate.

[0027] The particle size of silica is 300 nm.

[0028] The particle diameter of zinc oxide is 600 nm.

[0029] The relative molecular mass of polybutene succinate is 50,000.

[0030] The preparation method of the above-mentioned bioactive glass-ceramic comprises the following steps: adding sodium oxide, calcium oxide, phosphorus pentoxide, potassium fluoride, potassium oxide, silicon dioxide, zinc oxide, polybutene succinate into the crucible, Heat at 1600°C for 1.5h, quench to form a frit, and crush it into glass powder with a particle size of 500 microns; melt the glass powder in a crucible at 1100°C, and cool naturally.

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Abstract

The invention discloses a bioactive glass ceramic and a preparation method thereof. The ceramic comprises the following raw materials in parts by weight: 80-100 parts of sodium oxide, 10-20 parts of calcium oxide, 4-10 parts of phosphoric anhydride, 5-15 parts of potassium fluoride, 10-15 parts of potassium oxide, 20-30 parts of silicon dioxide, 10-40 parts of zinc oxide and 5-9 parts of polybutylene succinate. The preparation method comprises the following steps: putting sodium oxide, calcium oxide, phosphoric anhydride, potassium fluoride, potassium oxide, silicon dioxide, zinc oxide and polybutylene succinate in a crucible and maintaining the temperature at 1400-1800 DEG C for 1-2 hours; drastically cooling the crucible to form a fusion cake and crushing the fusion cake into glass powder; melting the glass powder at 1000-1200 DEG C in the crucible and naturally cooling the melted glass powder so that the bioactive glass ceramic is obtained. The bioactive glass ceramic is capable of actively participating in biological reactions so as to induce the contacted bone tissues to grow around the bioactive glass ceramic, so that a continuous bone material is formed.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a bioactive glass ceramic and a preparation method thereof. Background technique [0002] Bone defects have always been a medical problem. At present, the ideal method is autologous or allogeneic bone grafting, and autologous bone grafting is widely regarded as the "gold standard" for measuring bone graft fusion. Although autologous bone grafting has many advantages, such as adapting to the regeneration of surrounding bone tissue, there are still some disadvantages, such as limited donors for autologous bone grafting, secondary trauma, increased surgical difficulty, and a certain failure rate. Allograft bone sometimes cannot stimulate osteogenesis, and often induces adverse reactions. Research on new bone substitute products has become a common problem faced by medical workers and material workers. The new type of glass-ceramic can replace bone tissue to a certain extent, but i...

Claims

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Application Information

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IPC IPC(8): C03C10/16
Inventor 潘林根刘大学郭玉芹
Owner SUZHOU VIVOTIDE BIOTECH
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