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Pharmaceutical composition for improving psychological sub-health status as well as preparation method and application thereof

A technology of healthy state and composition, applied in the direction of drug combination, application, food preparation, etc., can solve the problems of slow evolution process, complex reasons for the development of mental sub-health state, lack of treatment methods, etc.

Active Publication Date: 2015-07-01
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The reasons for the occurrence and development of mental sub-health are complex, the evolution process is slow, and are closely related to social environment, economic culture, genetics, and physical fitness. Modern medicine still lacks effective treatment methods for it.

Method used

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  • Pharmaceutical composition for improving psychological sub-health status as well as preparation method and application thereof
  • Pharmaceutical composition for improving psychological sub-health status as well as preparation method and application thereof
  • Pharmaceutical composition for improving psychological sub-health status as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 pharmaceutical composition

[0016] Weigh 5 parts of cinnamon, dry and pulverize, add 10 times the amount of distilled water, microwave (power 800W) to assist extraction, filter, and extract the filtrate 3 times with n-hexane, combine the extracts, concentrate under reduced pressure, and obtain the cinnamon extract; 15 parts of Huang, 20 parts of Lily, mixed, crushed, added 10 times the amount of water microwave-assisted extraction twice, 20 minutes each time, combined the extracts, separated by D101 macroporous adsorption resin column chromatography, and then eluted with water to remove Impurities are then eluted with 50% ethanol, the eluate is collected, concentrated, and vacuum-dried to obtain the Lily Rehmannia extract; the above two extracts are mixed evenly to obtain the product.

Embodiment 2

[0017] The establishment of embodiment 2 psychological sub-healthy rat model

[0018] Modeling with compound factors and non-physical stimuli, namely, empty bottle stimulation, electric shock emotional stimulation, irregular diet stimulation, day and night reversal stimulation, and social failure stimulation, to simulate people's eating disorder and irregular work and rest in a highly competitive social environment , Psychological sub-health state caused by excessive mental stress and social failure.

[0019] I empty bottle stimulation: train all rats to carry out 7d empty bottle drinking training. The rats were only given ten-minute regular drinking water at 9:00-9:10 and 21:00-21:10 every day. And each time before giving water, the rats were given three reminders that the water bottles collided with each other.

[0020] After training, start the experiment. Except for the blank group, the other groups were randomly given an empty bottle stimulation at the time of drinking...

Embodiment 3

[0025] Embodiment 3 pharmacodynamic experiment

[0026] 1 experimental animal

[0027] SD adult male healthy rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2014-0012).

[0028] 2 experimental drugs

[0029] Cinnamon, Rehmannia glutinosa, and Lily decoction pieces were purchased from Shanxi Huayang Pharmaceutical Co., Ltd. (batch numbers 120501384, 120519070, and 120816091, respectively). The preparation method of the pharmaceutical composition is the same as in Example 1, and is divided into a high-dose group (22g crude drug / kg), a medium-dose group (11g crude drug / kg), and a low-dose group (5.5g crude drug / kg). Positive control drug: venlafaxine hydrochloride (Chengdu Kanghong Pharmaceutical Group Co., Ltd., specification: 25 mg / tablet, batch number: 090705). Diazepam (Beijing Yimin Pharmaceutical Factory, specification: 2.5mg / capsule, batch number: 0405281). All other chemical reagents were of analytical grade.

[00...

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Abstract

The invention discloses a pharmaceutical composition for improving psychological sub-health status as well as a preparation method and application thereof the pharmaceutical composition. The pharmaceutical composition is prepared from cassia bark, dried rehamnnia root and lily in a certain mass proportion by use of an appropriate extraction method. The result of a pharmacological experiment indicates that the pharmaceutical composition is capable of remarkably increasing the sweet water preference rate of mice in psychological sub-health animal models, and the opening times ratio and the opening time scale of an elevated cross arm and reducing the mistake times and the dark box stay time in a rat step-through test, and therefore, the pharmaceutical composition has the effects of obviously improving symptoms such as depression, anxiety and insomnia and improving the memory of learning.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for improving psychological sub-health state, its preparation method and application. Background technique [0002] Mental sub-health is an intermediate state between mental health and mental illness. People in this state, although there is no clear organic disease in the body, have begun to experience various uncomfortable feelings and symptoms psychologically, mainly manifested as unexplained depression, anxiety, learning and memory decline, sleep disturbance, etc. If it does not attract enough attention, it will easily lead to the occurrence of mental illness. [0003] From mental health to mental illness is a process from quantitative change to qualitative change. The occurrence of neuropsychiatric diseases such as depression, anxiety and schizophrenia is mostly due to the continuous aggravation of mental sub-health. Therefore, early detection an...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P25/00A61P25/24A61P25/22A23L1/29A23L33/00
Inventor 田俊生
Owner SHANXI UNIV
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