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Ceramide nano-emulsion and preparation method thereof

A technology of ceramide and nanoemulsion, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc. It can solve the problems of poor stability, poor biocompatibility, and difficulty in achieving efficacy, so as to increase content and reduce usage , good water dispersibility and biocompatibility

Active Publication Date: 2015-07-01
王亚平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the purposes of the present invention is to solve the problem of high emulsifier content, poor biocompatibility, poor stability, and difficulty in achieving efficacy in the above-mentioned ceramide cosmetic emulsion. To solve technical problems such as the role of emulsifier, provide a ceramide nanoemulsion with low content of emulsifier, relatively high content of active ingredient ceramide, good efficacy, good biocompatibility and high stability

Method used

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  • Ceramide nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A ceramide nanoemulsion, calculated by weight percentage, its raw material composition and content are as follows:

[0035] Grease 14 %

[0036] Emulsifier 1 %

[0037] Ceramide 3 %

[0038] Polyol 8 %

[0039] Inorganic salt 0.1 %

[0040] 73.9% of the balance is deionized water;

[0041] The oil is a synthetic oil, and the synthetic oil is caprylic capric triglyceride, a cosmetic grade product provided by Lubrizol (U.S.);

[0042] The emulsifier is a Gemini surfactant, and the Gemini surfactant is bis(lauroylamide glutamine) sodium lysine, a cosmetic grade product produced by Asahi Kasei Co., Ltd. (Japan);

[0043] The ceramide is ceramide 2, a cosmetic grade product provided by Takasago (Japan);

[0044] Described polyhydric alcohol is glycerol, the industrial grade product that Sinopharm Group Chemical Reagent Co., Ltd. provides;

[0045] The inorganic salt is sodium chloride, an industrial-grade product provided by Sinopharm Chemical Reagent Co., Ltd.

[00...

Embodiment 2

[0053] A ceramide nanoemulsion, calculated by weight percentage, its raw material composition and content are as follows:

[0054] Grease 15 %

[0055] Emulsifier 2 %

[0056] Ceramide 1 %

[0057] Polyol 10 %

[0058] Inorganic salt 0.1 %

[0059] 71.9% of the balance is deionized water;

[0060] The oil is vegetable oil, and the vegetable oil is olive oil, an industrial-grade product provided by Dike Fine Chemicals;

[0061] The emulsifier is a Gemini surfactant, and the Gemini surfactant is 1,2-bis[N-methyl-N-dodecyl-N-sulfopropyl]ethylenediamine betaine (GBS12) , industrial-grade products provided by Shanghai Yantuo Biotechnology Co., Ltd.;

[0062] The ceramide is ceramide 2, a cosmetic grade product provided by Takasago (Japan);

[0063] The polyol is 1,3-butanediol, an industrial-grade product provided by Sinopharm Chemical Reagent Co., Ltd.;

[0064] The inorganic salt is potassium chloride, an industrial-grade product provided by Sinopharm Chemical Reagent Co....

Embodiment 3

[0072] A ceramide nanoemulsion, calculated by weight percentage, its raw material composition and content are as follows:

[0073] Grease 12 %

[0074] Emulsifier 0.2 %

[0075] Ceramide 0.8 %

[0076] Polyol 10 %

[0077] Inorganic salt 0.1 %

[0078] 76.9% of the balance is deionized water;

[0079] The oil is vegetable oil, and the vegetable oil is wheat germ oil, an industrial-grade product provided by Dike Fine Chemicals;

[0080] The emulsifier is a Gemini surfactant, and the Gemini surfactant is bis(lauramide glutamine) sodium lysine, a cosmetic grade product produced by Asahi Kasei Co., Ltd. (Japan);

[0081] The ceramide is ceramide 2, a cosmetic grade product provided by Takasago (Japan);

[0082] Described polyhydric alcohol is propylene glycol, the industrial grade product that Sinopharm Chemical Reagent Co., Ltd. provides;

[0083] The inorganic salt is sodium chloride, an industrial-grade product provided by Sinopharm Chemical Reagent Co., Ltd.

[0084] T...

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Abstract

The invention discloses a ceramide nano-emulsion and a preparation method thereof. The ceramide nano-emulsion is composed of the following components by weight percentage: 0.1-8% of ceramide, 0.01-5% of emulgator, 5-30% of grease, 6-20% of polyhydric alcohols, 0.01-1% of inorganic salt and the balance of water. The preparation method comprises the following steps: mixing the ceramide and the grease and heating till the ceramide is completely dissolved; adding the emulgator and the polyhydric alcohols to obtain an oil phase component, mixing the inorganic salt with the water to obtain a water phase component, respectively heating the oil phase component and the water phase component to 80-90 DEG C, adding the water phase component into the oil phase component, homogenizing and emulsifying; performing high-pressure homogenizing on the obtained crude emulsion under the pressure of 150-600 bar under the condition that the number of cycle is 2-5 to obtain the ceramide nano-emulsion, wherein after the ceramide nano-emulsion is stored for 30d at a high temperature of 50 DEG C, the particle size is basically the same. The ceramide nano-emulsion is excellent in water dispersibility and biocompatibility and can be randomly matched with the cosmetic formula at normal temperature.

Description

technical field [0001] The invention relates to a ceramide nanoemulsion and a preparation method thereof, belonging to the technical field of cosmetic preparation. Background technique [0002] Ceramide is the main component (>40%) of intercellular lipids in the stratum corneum of human skin. Anti-aging and other functions. However, with age, the natural ceramides in human skin will gradually decrease, leading to skin barrier dysfunction, dry skin, desquamation, rough skin, reduced elasticity, and increased wrinkles. [0003] In view of the special function and curative effect of ceramide on the skin, in recent years, ceramide has also rapidly become a new type of advanced cosmetic bioactive additive for skin care and hair care. However, ceramide is insoluble in water and oil, and it is easy to crystallize out when directly applied in the formula. [0004] Most of the ceramide cosmetic emulsions currently prepared are ceramide dispersions with high content of emulsi...

Claims

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Application Information

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IPC IPC(8): A61K8/68A61K8/92A61K8/06A61Q19/00A61Q19/08
Inventor 张婉萍田永红郭奕光朱海洋
Owner 王亚平
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