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Starch soft capsules

A soft capsule and starch technology, which is applied in the field of medicine, can solve the problems of long disintegration time limit and high damage rate, and achieve the effect of high appearance transparency, low damage rate and shortened disintegration time limit

Inactive Publication Date: 2015-06-24
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The plant-based soft capsule shell provided by the invention has the advantages of high transparency and good flexibility, and overcomes the defects of traditional soft capsules that are prone to microorganisms, but the plant-based capsule made of the shell still has a long disintegration time limit , High breakage rate and other issues

Method used

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  • Starch soft capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Mix hydroxypropyl starch and rice starch at a weight ratio of 20:5 to obtain matrix starch, take 20 parts of the matrix starch, 5 parts of xylitol, 5 parts of mannitol and 1 part of carrageenan as a gelling agent, and mix with deionized water After 30 parts are mixed, obtain the raw material for preparing starch soft capsules.

[0020] The raw material mixture obtained above was used to prepare soft capsules by conventional soft capsule preparation techniques, and the prepared soft capsules were subjected to disintegration time limit and burst tests.

Embodiment 2

[0022] Mix hydroxypropyl starch, pregelatinized starch and rice starch at a weight ratio of 20:10:10 to obtain matrix starch, take 30 parts of matrix starch, 15 parts of glycerin and 10 parts of carrageenan as a gelling agent, and deionized 40 parts of water are mixed to obtain raw materials for preparing starch soft capsules.

[0023] The raw material mixture obtained above was used to prepare soft capsules by conventional soft capsule preparation techniques, and the prepared soft capsules were subjected to disintegration time limit and burst tests.

Embodiment 3

[0025] Mix oxidized starch and rice starch at a weight ratio of 45:18 to obtain matrix starch, take 45 parts of the matrix starch, 25 parts of glycerin and 5 parts of carrageenan as a gelling agent, mix with 50 parts of deionized water to obtain Raw material of starch soft capsule.

[0026] The raw material mixture obtained above was used to prepare soft capsules by conventional soft capsule preparation techniques, and the prepared soft capsules were subjected to disintegration time limit and burst tests.

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Abstract

The invention relates to capsules widely used in the industries of medicines, health products and foods, and particularly relates to starch soft capsules. The starch soft capsules contain starch and a plasticizer which are used as a matrix, and vegetable gelatine used as a gel, a raw material for preparing the starch soft capsules is obtained after mixing the starch, the plasticizer and the vegetable gelatine with deionized water, and then the starch soft capsules are prepared by a conventional process for preparing soft capsules. The plasticizer in the starch soft capsules disclosed by the invention is used for improving the movability of the molecular chains of starch, reducing the crystallinity of the molecular chains of the starch, and further playing a role of enhancing the elongation and flexibility of the starch. In addition, the starch soft capsules prepared from the abovementioned raw materials have a low breakage rate and a good disintegration performance.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a starch soft capsule. Background technique [0002] Soft capsule is a kind of preparation that seals semi-solid substances such as oily liquid or suspension and emulsion in capsule, and is widely used in health care products and pharmaceutical industries. Traditional soft capsules are made from gelatin, which is a purified product of collagen in animal (cattle, pig) skin, bone, tendon or ligament after incomplete acid hydrolysis, alkaline hydrolysis or enzymatic degradation. In recent years, the exposure of "mad cow disease" and "poisonous capsule" incidents has caused consumers to have a serious crisis of trust in gelatin products. In addition, gelatin itself has many shortcomings, such as easy to breed microorganisms, poor flexibility and other defects, and its production process will inevitably have animal protein residues, which will cross-link with aldehyde-containing c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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