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Pyrolin microcapsule and preparation method thereof

A technology of carinacein and microcapsules, which is applied in the field of preparation of carinacein microcapsules, can solve problems such as not being seen, and achieve the effects of improved stability, high targeting performance, and strong antibacterial effect

Active Publication Date: 2015-06-17
河南华牧生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on microcapsules of active ingredients of traditional Chinese veterinary medicine in China.

Method used

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  • Pyrolin microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Wintergreen microcapsules, including the following product components (weight 700g):

[0038] Gelatin 200g

[0039] Wintergreen 500g.

[0040] The process steps are:

[0041] 1. Weigh the gelatin, add 70ml of distilled water and heat it on a warm water bath to fully dissolve it into a transparent state until there are no small particles.

[0042] 2. Weigh 100ml of gelatin solution, 80 0 C water bath heating 1h.

[0043] 3. Under constant stirring (stirring speed is 400r.min) -1 ) into the gelatin solution and stir well.

[0044] 4. Take another 400ml of liquid paraffin and heat it in a water bath to 80 0 C, add 5ml Tween-80, after fully dissolving, slowly add the gelatin solution containing luteolin in operation 3 into the liquid paraffin under constant stirring.

[0045] 5. Continue to stir on the water bath for 20 minutes, then put the whole system into the ice-water bath, and keep stirring in the ice-water bath for 1 hour.

[0046] 6. Add 30ml of formaldehy...

Embodiment 2

[0048] Wintergreen microcapsules, including the following product components (weight 700g):

[0049] Gelatin 300g

[0050] Wintergreen 400g.

[0051] The process steps are:

[0052] 1. Weigh the gelatin, add 70ml of distilled water and heat it on a warm water bath to fully dissolve it into a transparent state until there are no small particles.

[0053] 2. Weigh 110ml of gelatin solution, 80 0 C water bath heating 2h.

[0054] 3. Under constant stirring (stirring speed is 400r.min) -1 ) into the gelatin solution and stir well.

[0055] 4. Take 500ml of liquid paraffin and heat it in a water bath to 80 0 C, add 6ml Tween-80, after fully dissolving, slowly add the gelatin solution containing glutin in operation 3 into the liquid paraffin under constant stirring.

[0056] 5. Continue to stir on the water bath for 20 minutes, then put the whole system into the ice water bath, and keep stirring in the ice water bath for 1 hour.

[0057] 6. Add 40ml of formaldehyde to solidi...

Embodiment 3

[0059] Wintergreen microcapsules, including the following product components (weight 700g):

[0060] Gelatin 400g

[0061] Wintergreen 300g.

[0062] The process steps are:

[0063] 1. Weigh the gelatin, add 70ml of distilled water and heat it on a warm water bath to fully dissolve it into a transparent state until there are no small particles.

[0064] 2. Weigh 100ml of gelatin solution, 80 0 C water bath heating 1-2h.

[0065] 3. Under constant stirring (stirring speed is 400r.min) -1 ) into the gelatin solution and stir well.

[0066] 4. Take another 600ml of liquid paraffin and heat it in a water bath to 80 0 C, add 7ml Tween-80, after fully dissolving, slowly add the gelatin solution containing glutin in operation 3 into the liquid paraffin under constant stirring.

[0067] 5. Continue to stir on the water bath for 20 minutes, then put the whole system into the ice water bath, and keep stirring in the ice water bath for 1 hour.

[0068] 6. Add 50ml of form...

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Abstract

The invention discloses a preparation method of a pyrolin microcapsule, wherein a microcapsule structure is formed by wrapping pyrolin with gelatin. The pyrolin is a traditional Chinese medicine effective component obtained by artificial chemical synthesis and has strong antibacterial activity; the microcapsule is used as a drug carrier, and has many characteristics of drug stability improvement, sustained or controlled release effect, targeted property, high bioavailability and the like superior to those of a traditional preparation; the pyrolin microcapsule can effectively improve the stability of drug preparation, changes the taste sense, and can be applied to a clinical new preparation.

Description

technical field [0001] The invention belongs to the field of veterinary drug research, and in particular relates to a preparation method technology of wintergreen microcapsules. Background technique [0002] Wintergreen, also known as little guohun grass and diarrhea grass, is a plant of the wintergreen family. Traditional Chinese medicine generally uses it in combination with other medicines for dispelling rheumatism, tonifying the kidney, and stopping bleeding. Single wintergreen has the functions of nourishing the waist and kidneys, promoting blood circulation and regulating menstruation, but there are few records of treating acute infections. In 1957, Mr. Bao Youdi, a Chinese scholar, conducted an antimicrobial experiment on its single prescription, and the results showed that the effect of wintergreen on various types of Shigella was better than that of sulfonamides, synmycin, streptomycin, aureomycin, and berberine , Plantain, etc. In the same year, the Department o...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/05A61K47/42A61P31/04A61P1/12A61P7/10
Inventor 梁剑平郝宝成尚若锋王学红刘宇郭文柱郭志廷陶蕾赵凤舞贾忠杨珍
Owner 河南华牧生物科技有限公司
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