Method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol

Abstract

The invention discloses a method for simultaneously measuring content of nicotine, 1,2-propylene glycol and glycerol in electronic smoke sol. The method comprises the following steps: smoking electronic cigarettes by utilizing a smoking machine provided with a switch connection device, trapping the nicotine, 1,2-propylene glycol and glycerol in the gas sol by adopting a Cambridge filter, by taking an isopropyl alcohol solution added with an interior label as an extraction agent, extracting the nicotine on the filter by using an oscillation extraction method, analyzing by matching a gas chromatograph with a hydrogen flame ionization detector, and performing internal standard method determination. The method disclosed by the invention has the advantages that the efficiency of the adopted measurement method is high, the switch connection device is high in air impermeability, simple and effective, a linear relation among the nicotine, 1,2-propylene glycol and glycerol is good in the respective linearity range, the detection limit is 0.40-2.16ug / mL, the average recovery rate of three labeling levels is between 96.0 and 102.0 percent, and the relative standard deviation is smaller than 3.60 percent. Therefore, the method is high in sensitivity and high in repeatability and recovery rate.

Description

technical field [0001] The invention relates to the technical field of physical and chemical inspection of electronic cigarette products, in particular to a gas chromatography method for simultaneously measuring the contents of nicotine, 1,2-propanediol and glycerol in electronic cigarette aerosol. Background technique [0002] Electronic cigarettes (e-cigarettes), also known as electronic nicotine delivery systems (ENDS), are a new form of nicotine intake that looks similar to cigarettes. Over the years, e-cigarettes have used "health care", "quit smoking" and "cleaning the lungs" as their promotional slogans, with the Internet as the main marketing channel, and their sales in China have increased significantly. However, there are still few studies on the determination of the main components of e-cigarette aerosols. [0003] Nicotine, 1,2-propanediol and glycerol are the main chemical components in electronic cigarette pods and e-liquids. 1,2-Propanediol and glycerin are ...

AI Technical Summary

Problems solved by technology

There are many reports on the determination of nicotine content in tobacco and cigarette smoke[3, 4], but the weight, shape, aerosol (smoke) generation mechanism, and smoking of electronic cigarettes and traditional cigarettes are different. There are great differences in mode, chemical composition, single-puff nicotine content and content difference between puffs, so the determination method of nicotine in mainstream smoke of traditional cigarettes is not fully applicable to e-cigarettes[5 , 6]

There are relatively few studies on the determination of nicotine content in e-cigarette aerosol, such as Goniewicz, M[7] and Michael, L[8] etc. using cold hydrazine to capture- Gas chromatography has been used to analyze the nicotine components of e-cigarette liquid and aerosol, but the operation of the cold hydrazine capture method is relatively time-consuming and cumbersome, and the amount of capture liquid used is relatively large (100 mL). Waste, the second is that the large amount of capture liquid used has a relatively large dilution effect on nicotine, which may not be detected for e-cigarette samples with low nicotine content and low number of puffs (such as less than 5 puffs). Therefore, It is urgent to develop a high-throughput method for the simultaneous determination of nicotine, 1,2-propanediol and glycerol in aerosols to meet the requirements of analysis and detection

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