Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for dissolving ambroxol hydrochloride raw materials

A technology of ambroxol hydrochloride and raw materials, applied in the field of preparations, can solve the problems of being easily oxidized and degraded, ambroxol hydrochloride raw materials are difficult to dissolve in water, etc., and achieve good solubility, good uniformity, and the effect of preventing oxidative degradation

Active Publication Date: 2015-05-13
SHANGHAI WORLDBEST ANHUI JINHUI PHARMA CO LTD
View PDF5 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of above-mentioned deficiencies in the prior art, the object of the present invention is to provide a kind of dissolving method of ambroxol hydrochloride raw material, aims to solve the problem that ambroxol hydrochloride raw material is insoluble in water and easily oxidatively degraded in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for dissolving ambroxol hydrochloride raw materials
  • Method for dissolving ambroxol hydrochloride raw materials
  • Method for dissolving ambroxol hydrochloride raw materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The present invention provides a kind of dissolving method of ambroxol hydrochloride raw material, in order to make the purpose of the present invention, technical scheme and effect clearer, definite, below the present invention is further described in detail. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0017] Such as figure 1 Shown, the present invention provides a kind of dissolving method of ambroxol hydrochloride raw material, wherein, described step comprises:

[0018] S100. Take 25L of water for injection in a magnetically stirred stainless steel barrel, add 3.0kg of citric acid, 2.4kg of disodium hydrogen phosphate, and 1.5kg of sodium bisulfite as auxiliary materials, and stir at a speed of 60 rpm for 10 minutes. After dissolving, add the ambroxol hydrochloride of 0.9kg, and stir 10 minutes with the rotating speed of 60 rev / mins, make the concentrated ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for dissolving ambroxol hydrochloride raw materials. The method comprises the following steps: A, taking 25L of water for injection, adding auxiliary materials such as 3.0kg of citric acid, 2.4kg of disodium hydrogen phosphate and 1.5kg of sodium hydrogen sulfite, and adding 0.9kg of ambroxol hydrochloride after dissolving, thereby obtaining the concentrated liquor of ambroxol hydrochloride for later use; B, adding the concentrated liquor of ambroxol hydrochloride into a dilution tank, adding water for injection to reach 3000L, and stirring for 10 minutes, thereby obtaining an initial solution of ambroxol hydrochloride; and C, performing circulating filtration by virtue of a titanium stick filter, and preparing the ambroxol hydrochloride solution at the temperature of 50-60 DEG C by virtue of a first pleated filter cartridge filter and a second pleated filter cartridge filter. According to the method disclosed by the invention, ambroxol hydrochloride can be completely dissolved in water, the uniformity is high, the oxidative degradation problem of ambroxol hydrochloride can be effectively solved, and the ambroxol hydrochloride solution with good dissolving property and difficulty in denaturation is prepared.

Description

technical field [0001] The invention relates to the field of preparations, in particular to a method for dissolving ambroxol hydrochloride raw materials. Background technique [0002] The raw material of ambroxol hydrochloride is the active ingredient of ambroxol hydrochloride glucose injection, which can promote the elimination of viscous secretions in the respiratory tract and reduce the retention of mucus, thus significantly promoting expectoration. It is suitable for patients with abnormal sputum secretion and excretion. Acute and chronic respiratory diseases with poor sputum function. Yet the solubility of ambroxol hydrochloride is little, and it is extremely difficult to dissolve in water, therefore can affect the homogeneity of this medicinal liquid, and ambroxol hydrochloride is easily oxidized and degraded in addition, is unfavorable for long-term preservation. [0003] Therefore, the prior art still needs to be improved and developed. Contents of the invention ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/08A61K31/137A61K47/12A61P11/10
Inventor 方超温克冰夏蕴琼刘将王军王殿林张坤崔同欣王振朋
Owner SHANGHAI WORLDBEST ANHUI JINHUI PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com