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Gastrointestinal contrast agent that has the effect of treating gastrointestinal ulcer and has good application effect

A digestive tract and contrast agent technology, applied in X-ray contrast agent preparation, medical preparations containing active ingredients, digestive system, etc., to achieve the effects of low toxic and side effects, simple preparation method, and low side effects

Inactive Publication Date: 2019-09-10
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in clinical practice, the more patients with ulcer disease, the more difficult it is to smear the gastrointestinal tract contrast agent due to factors such as exudation and edema of the surrounding mucosa, spasm of the gastrointestinal wall, and more content and retained fluid caused by the ulcer. (The inventor once encountered a patient with ulcerative gastric cancer, who induced the perforation of the cancerous ulcer 2 hours after using barium sulfate dry suspension for imaging); chemical preparations such as liquid diatrizoate meglumine often aggravate the emergency stimulation and inflammatory response in the gastrointestinal ulcer lesion area

Method used

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  • Gastrointestinal contrast agent that has the effect of treating gastrointestinal ulcer and has good application effect
  • Gastrointestinal contrast agent that has the effect of treating gastrointestinal ulcer and has good application effect
  • Gastrointestinal contrast agent that has the effect of treating gastrointestinal ulcer and has good application effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: This contrast medium is used for duodenal ulcer case.

[0043]Get barium sulfate dry suspension 150g, add water 180ml, Chinese medicine extract 60g, take barium sulfate dry suspension, water and Chinese medicine extract after mixing. Among them, the traditional Chinese medicine extract is obtained through the following preparation methods: 60g of seabuckthorn seed oil, 60g of black medicine, 45g of Patrinia, 15 parts of Scutellaria baicalensis, 15 parts of cassia twig, 45g of Radix Rhizome, 60g of licorice, 30g of turmeric, 21g of orange leaf , Angelica 20g, Poria 45g, Fritillaria 24g, Radix Pseudostellariae 15g, Panax notoginseng 15g, pearl powder 30g. Mix the above traditional Chinese medicines, add water to immerse, decoct for 30 minutes, filter to obtain a filtrate, concentrate the filtrate under reduced pressure and freeze-dry to obtain the Chinese medicine extract.

[0044] refer to figure 1 As shown, the patient Xu Moumou, female, 48 years old, ha...

Embodiment 2

[0046] Embodiment 2: This contrast agent is used for benign ulcer cases in the gastric angle notch area.

[0047] Get 140g of compound meglumine diatrizoate, 60g of Chinese medicine extract, add 230ml of water, mix compound recipe diatrizoate meglumine, Chinese medicine extract and water and take it. Among them, the traditional Chinese medicine extract is obtained through the following preparation methods: seabuckthorn seed oil 60g, black medicine 60g, Patrinia 40g, scutellaria baicalensis 40g, cassia twig 30g, Yuanhu 40g, licorice 60g, turmeric 50g, orange leaf 46g, angelica 60g, Poria 50g, Fritillaria 28g, Radix Pseudostellariae 20g, Panax notoginseng 30g, pearl powder 40g. Mix the above-mentioned traditional Chinese medicines, add water to immerse them, decoct for 60 minutes, and filter to obtain a filtrate. The filtrate is concentrated under reduced pressure and then freeze-dried to obtain the Chinese medicine extract.

[0048] refer to image 3 As shown, the patient Wan...

Embodiment 3

[0051] Embodiment 3: This contrast agent is used for cases of ulcerative gastric cancer on the lesser curvature side of the gastric body.

[0052] Take barium sulfate dry suspension 110g, Chinese medicine extract 40g, add water 200ml; Barium sulfate dry suspension, Chinese medicine extract and water mix and take. Among them, the traditional Chinese medicine extract is obtained through the following preparation methods: 44g of seabuckthorn seed oil, 48g of black medicine, 32g of Patrinia, 16g of Scutellaria baicalensis, 16g of cassia twig, 32g of Radix Rhizome, 44g of licorice, 40g of turmeric, 16g of orange leaf, and 16g of angelica 44g, Poria cocos 34g, Fritillaria 18g, Radix Pseudostellariae 12g, Panax notoginseng 14g, pearl powder 24g; mix the above traditional Chinese medicines, add water to immerse, decoct for 40min, filter to obtain the filtrate, the filtrate is concentrated under reduced pressure and freeze-dried to obtain the Chinese medicine extract thing.

[0053] r...

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Abstract

The invention relates to a digestive tract contrast agent having the effect of treating gastrointestinal ulcer and good smearing effect. The digestive tract contrast agent disclosed by the invention comprises barium sulphate dry suspension or compound meglumine diatrizoate, sea-buckthorn oil, the root of three-nerved spicebush, patrinia, scutellaria baicalensis, cassia twig, rhizoma corydalis, liquorice, curcuma aromatic, tangerine leaf, Chinese angelica, poria cocos, thunberg fritillary bulb, radix pseudostellariae, pseudo-ginseng and pearl powder. The digestive tract contrast agent provided by the invention is scientific in composition; the preparation method of the digestive tract contrast agent in various dosage forms is simple; the prepared digestive tract contrast agent is convenient to take and can be applied to patients suffering from different cases; and the digestive tract contrast agent has good contrast effect.

Description

technical field [0001] The invention relates to a digestive tract contrast agent with the effect of treating gastrointestinal ulcer and good application effect. Background technique [0002] Radiologists generally face patients with different degrees of gastrointestinal diseases in the digital gastrointestinal imaging examination of the clinical work. Whether it is functional or organic diseases, the patients' gastrointestinal mucosa has different degrees. Injuries and lesions: mucosal erosion, exudative edema, or gastrointestinal wall ulcers of different degrees, or necrotic ulcers of tumor space-occupying lesions, etc. [0003] Under the current technical conditions and clinically according to the needs of the condition, the commonly used gastrointestinal contrast agents are barium sulfate dry suspension (for patients without gastrointestinal obstruction) and liquid preparation compound diatrizoate meglumine contrast agent (for patients with possible gastrointestinal obstr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/04A61K36/9066A61P1/04A61K35/618
Inventor 董杰王焕君任秀红
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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