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Method for preparing cardiovascular drug sustained-release capsules

A sustained-release capsule and cardiovascular technology, which is applied to cardiovascular system diseases, drug delivery, drug combination, etc., to achieve the effects of reducing the number of medications, long action time, and large surface area

Inactive Publication Date: 2015-04-29
SHANGHAI DESANO PHARMA INVESTMENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the inconvenience of large doses and multiple daily administrations, it is necessary to develop it into a sustained-release preparation

Method used

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  • Method for preparing cardiovascular drug sustained-release capsules
  • Method for preparing cardiovascular drug sustained-release capsules
  • Method for preparing cardiovascular drug sustained-release capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The composition prescription of capsule content described in the present embodiment is as follows:

[0033]

[0034] The preparation process of the sustained-release capsule described in the present embodiment is as follows:

[0035] a) First pass labetalol hydrochloride and filler microcrystalline cellulose through a 40-mesh sieve for pretreatment, then accurately weigh according to the prescription amount and mix well; then the binder hydroxypropyl methylcellulose (HPMC) Prepare a 2% aqueous solution and add it to the mixed material to make a soft material;

[0036] b) Extrude the prepared soft material into a short column with a 0.8mm screen, then use a centrifugal granulator to make pellets, and then dry them in a fluidized bed at 60±30°C;

[0037] c) sieve the dried pellets, and take 16-40 mesh pellets for later use; dissolve the remaining pellets with water into a solution or suspension, and then prepare 24-35 mesh pellets in a fluidized bed; combine the obtai...

Embodiment 2

[0040] The composition prescription of capsule content described in the present embodiment is as follows:

[0041]

[0042] The preparation process of the sustained-release capsule described in the present embodiment is as follows:

[0043] a) First pretreat pucharolol hydrochloride, filler microcrystalline cellulose and sucrose powder through a 40-mesh sieve, then accurately weigh and mix uniformly according to the prescription amount; then add the binder hydroxypropyl methylcellulose (HPMC) is formulated into a 0.5% aqueous solution, and added to the mixed material to make a soft material;

[0044] b) Extrude the prepared soft material into a short column with a 0.8mm screen, then use a centrifugal granulator to make pellets, and then dry them in a fluidized bed at 60±30°C;

[0045] c) sieve the dried pellets, and take 16-40 mesh pellets for later use; dissolve the remaining pellets with water into a solution or suspension, and then prepare 24-35 mesh pellets in a fluidi...

Embodiment 3

[0048] The composition prescription of capsule content described in the present embodiment is as follows:

[0049]

[0050]

[0051] The preparation process of the sustained-release capsule described in the present embodiment is as follows:

[0052] a) Firstly pass nifedipine and filler microcrystalline cellulose through a 60-mesh sieve for pretreatment, then accurately weigh according to the prescription amount and mix them evenly; then prepare the binder hydroxypropyl cellulose (HPC) to 1% aqueous solution, and add the mixed material to make soft material;

[0053] b) Extrude the prepared soft material into a short column with a 0.5mm screen, then use a centrifugal granulator to make pellets, and then dry them in a fluidized bed at 60±30°C;

[0054] c) Sieve the dried pellets, and take 20-50 mesh pellets for later use; dissolve the remaining pellets with water into a solution or suspension, and then prepare 16-40 mesh pellets in a fluidized bed; combine the obtained Al...

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Abstract

The invention discloses a method for preparing cardiovascular drug sustained-release capsules. The method comprises the following steps: (1) according to a prescription, preparing materials into a soft material; (2) preparing the soft material into drug loading pellets in an extrusion-spheronization way; (3) screening dried pellets, and preparing sustained-release pellets and immediate-release pellets; (4) according to the content of main drugs in the immediate-release pellets and the sustained-release pellets, quantitatively filling the immediate-release pellets and the sustained-release pellets in proportion, so as to obtain the sustained-release capsules. The cardiovascular drug sustained-release capsules prepared by the method can keep the stable blood drug concentration and longer action time, the reduction of toxic and side effects of medicine is facilitated, the effectiveness and safety of drug use are ensured, the frequency of taking medicine by patients can be reduced, and the medication compliance of patients is improved.

Description

technical field [0001] The invention relates to a method for preparing sustained-release capsules of cardiovascular drugs, which belongs to the technical field of preparation of pharmaceutical preparations. Background technique [0002] Cardiovascular drugs generally have a strong first-pass effect in the body, and their oral bioavailability is often low, and their absorption rate is related to the dosage form. Due to the short biological half-life, the maintenance time of effective blood drug concentration is short, and the blood drug concentration fluctuates greatly, ordinary tablets need to be taken several times a day to reach the effective therapeutic concentration. Due to the large dose and multiple administrations per day, it brings a lot of inconvenience to patients, so it is necessary to develop it into a sustained-release preparation. [0003] Compared with ordinary preparations, sustained-release preparations have the following advantages: ①Easy to take: general ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K45/00A61K31/609A61K31/4422A61K31/138A61P9/00
Inventor 李竟鹏陈亚姿
Owner SHANGHAI DESANO PHARMA INVESTMENT
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