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Traditional Chinese medicine preparation for treating swollen sore throats and production method of traditional Chinese medicine preparation

A technology of traditional Chinese medicine preparations and sore throat, which is applied in the field of traditional Chinese medicine preparations and its preparation, Chinese medicine preparations for treating sore throat and its preparation, which can solve the problems of inconsistent dissolution speed, decreased content of the main drug, and numbness of the contact surface. Good palatability, less toxic and side effects, and increased compliance

Inactive Publication Date: 2015-04-22
王景贺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extracts of traditional Chinese medicine are often bitter, and the palatability is poor after being made into buccal tablets, and there is an astringent feeling after the mouth. This may be caused by the inconsistency of the dissolution rate of the ingredients in the prescription, which causes fine numbness on the contact surface between the tablet and the tongue.
Secondly, buccal tablets often use hygroscopic excipients, so commercially available buccal tablets often cause changes in appearance and even a decrease in the content of the main drug due to moisture absorption

Method used

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  • Traditional Chinese medicine preparation for treating swollen sore throats and production method of traditional Chinese medicine preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Prescription: Nansha Ginseng 20g, Aster 27g, Scutellaria baicalensis 25g, Licorice 12g, Ophiopogon japonicus 12g, Evodia 6g, Polygonatum 10g, Menthol 0.2g, β-cyclodextrin 250g, Isomalt 200g, Lactose 150g and magnesium stearate 10g.

[0031]Preparation method: weigh Nansha ginseng, aster, scutellaria baicalensis, licorice, Ophiopogon japonicus, Evodia rutaecarpa and Polygonatum odoratum in proportion by weight, crush them through a 40-mesh sieve, add 3 times the volume of water to decoct 3 times, each time for 2.5 hours, and decoct together liquid, make the decoction concentrated to a thick paste with a relative density of 1.20 (60°C), cool, add ethanol to the thick paste to make the alcohol content reach 60%, let stand for 24 hours, filter and recover the supernatant Ethanol, dried into dry cream powder for later use; dissolve menthol with 95% ethanol, then add β-cyclodextrin inclusion compound to obtain menthol β-cyclodextrin inclusion compound for later use; dry cream...

Embodiment 2

[0033] Prescription: Nansha Ginseng 15g, Aster 35g, Scutellaria baicalensis 30g, Licorice 15g, Ophiopogon japonicus 10g, Evodia 10g, Polygonatum 8g, Menthol 0.1g, β-cyclodextrin 150g, Isomalt 300g, Lactose 90g, Magnesium stearate 15g and strawberry essence 20g.

[0034] Preparation method: weigh Nansha ginseng, aster, scutellaria baicalensis, licorice, Ophiopogon japonicus, Evodia rutaecarpa and Polygonatum odoratum in proportion by weight, crush them through a 60-mesh sieve, add 4 times the volume of water to decoct 3 times, each time for 3 hours, and decoct together The decoction was concentrated to a thick paste with a relative density of 1.22 (60°C), cooled, and ethanol was added to the thick paste to make the alcohol content reach 50%, and left to stand for 28 hours, filtered and recovered in the supernatant Ethanol, dried into dry cream powder for later use; dissolve menthol with 95% ethanol, then add β-cyclodextrin inclusion compound to obtain menthol β-cyclodextrin inc...

Embodiment 3

[0036] Prescription: Nansha Ginseng 25g, Aster 30g, Scutellaria baicalensis 20g, Licorice 10g, Ophiopogon japonicus 10g, Evodia rutaecarpa 10g, Polygonatum 15g, Menthol 0.5g, β-cyclodextrin 350g, Isomalt 250g, Lactose 120g and magnesium stearate 15g.

[0037] Preparation method: weigh Nansha ginseng, aster, scutellaria baicalensis, licorice root, Ophiopogon japonicus, Evodia rutaecarpa and Polygonatum odoratum in proportion by weight, crush them through a 60-mesh sieve, add 2 times the volume of water and decoct 3 times, each time for 4 hours, and decoct together The decoction was concentrated to a thick paste with a relative density of 1.18 (60°C), cooled, and ethanol was added to the thick paste to make the alcohol content reach 60%, and it was left to stand for 26 hours, filtered and recovered in the supernatant Ethanol, dried into dry cream powder for later use; dissolve menthol with 95% ethanol, then add β-cyclodextrin inclusion compound to obtain menthol β-cyclodextrin i...

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Abstract

The invention provides a traditional Chinese medicine preparation for treating swollen sore throats and a production method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is composed of traditional Chinese medicine active ingredients and pharmaceutically acceptable auxiliaries, wherein the traditional Chinese medicine active ingredients are extracted from ladybell root, aster, baikal skullcap root, liquorice root, dwarf lilyturf tuber, medcinal evodia fruit, fragrant solomonseal rhizome and menthol; the pharmaceutically acceptable auxiliaries include beta-cyclodextrin, isomaltitol, lactose and magnesium stearate. The traditional Chinese medicine preparation is reasonable in compatibility, good in taste and excellent in stability, and has a remarkable curative effect on swollen sore throats.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine preparation for treating sore throat and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compound prescriptions. Background technique [0002] Sore throat is a common main symptom of oropharynx and hypopharynx lesions. It is characterized by redness, swelling and pain in the throat, and discomfort in swallowing. It occurs mostly in the cold season of the year. Sore throat can be caused by anything that irritates the lining of the throat and oral cavity. These include: viruses, bacterial infections, allergic reactions, dust, cigarettes, exhaust fumes, hot drinks or food, teeth or gum infections can sometimes affect the throat, chronic cough, Extremely dry environments, gastroesophageal reflux, and speaking too loudly can also irritate the throat, and hoarsen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/20A61K47/40A61P11/04A61K31/045
Inventor 巫军丁萍月张亚琼张佳佳王忠华
Owner 王景贺
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