Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tranexamic acid external semisolid preparation and preparation method thereof

A tranexamic acid and semi-solid technology, applied in the field of medicine, can solve the problems of influence, poor transdermal ability of aqueous solution, etc., and achieve the effects of ensuring curative effect, wide application and convenient medication

Active Publication Date: 2015-04-08
贵州健瑞安药业有限公司
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the polarity of tranexamic acid is strong, and the transdermal ability of aqueous solution is poor, directly making tranexamic acid into a simple external preparation seriously affects its curative effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tranexamic acid external semisolid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1: Preparation of tranexamic acid gel for external use

[0041] Preparation of gel: Sprinkle 10.0g of Carbomer 940 evenly on the surface of 600.0g of purified water, place it for 4.0-4.5 hours and stir until it swells, then add 4.0g of triethanol and stir evenly, adjust the pH to 5-6 to obtain the matrix; take aminomethylcycline 50 g of tranexamic acid, 120.0 g of glycerin, and 1.0 g of ethylparaben were mixed evenly, and gradually added to the matrix under stirring, and then 215.0 g of purified water was added to make up to a sufficient amount, and after mixing, the tranexamic acid gel 200 sticks, 5 grams each.

Embodiment 2

[0042] Embodiment 2: the preparation of tranexamic acid gel for external use

[0043] Preparation of gel: Take 12.0g of Carbomer 940 and evenly sprinkle it on the surface of 600.0g of purified water, place it for 4.0-4.5 hours and stir until it swells, then add 4.2g of triethanol and stir evenly, adjust the pH to 5-6 to obtain the matrix; take aminomethylcycline Tranexamic acid 100g, glycerin 100.0g, and ethylparaben 1.1g were mixed evenly, gradually added to the matrix under stirring, and then 182.7.0g purified water was added to make up enough, after mixing, the tranexamic acid gel was potted 200 sticks, 5 grams each.

Embodiment 3

[0044] Embodiment 3: the preparation of tranexamic acid suppository

[0045] Suppository preparation: Take 72.5g of gelatin, add 190g of purified water, let it stand for 24 hours to make it fully wet, add 177.5g of glycerin and 35g of polyethylene glycol (400), heat and dissolve and mix evenly as the matrix, take 475g of matrix and add aminomethylcycline After 25g of acid was mixed evenly, it was degassed at 70°C for 2 hours, poured into the vaginal suppository mold, cooled, and solidified to obtain 50 tranexamic acid suppositories, each 10g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of pharmaceutical preparations and particularly discloses a tranexamic acid external semisolid preparation and a preparation method thereof. The semisolid preparation is one of gels, suppositories and ointments prepared from tranexamic acid serving as an active ingredient and other pharmaceutically acceptable auxiliary materials. The tranexamic acid external semisolid preparation disclosed by the invention has high physiological skin compatibility, and the haemostatic effect of the tranexamic acid is effectively improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a semi-solid preparation of tranexamic acid for external use and a preparation method thereof. Background technique [0002] Tranexamic acid is also known as tranexamic acid, tranexamic acid, the chemical name is trans-4-(aminomethyl)cyclohexanecarboxylic acid, molecular formula: C 8 h 15 NO 2 , molecular weight: 157.21. Trans-4-(aminomethyl)cyclohexanecarboxylic acid (abbreviated as trans-AMCA or AMCA), has significant anti-fibrinolytic activity, can stabilize fibrin, and is effective for coagulation factors, platelets, vascular factors and tissue factor disorders. It is an effective hemostatic agent and has been widely used clinically in China, and it is included in the new edition of the Chinese Pharmacopoeia. [0003] The external preparation can directly act on the target site, avoid the first-pass effect of the liver, increase the local concentration of the drug at the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/195A61K9/02A61K9/06A61P7/04
Inventor 吴乾方李仁祥孙立新黄阿三陈玉叶
Owner 贵州健瑞安药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com