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Tilmicosin enteric-coated pellets and preparation method thereof

A technology of tilmicosin and enteric-coated pellets, which is applied in the field of tilmicosin enteric-coated pellets and its preparation, can solve problems such as the taste-masking problem not involved in tilmicosin, and achieve good drug efficacy and high biological efficacy. Utilization, effects of avoiding impact

Active Publication Date: 2015-12-09
CHINANIMAL NANJING VETERINARY DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the literature does not address the issue of taste masking of tilmicosin

Method used

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  • Tilmicosin enteric-coated pellets and preparation method thereof
  • Tilmicosin enteric-coated pellets and preparation method thereof

Examples

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preparation example Construction

[0034] The preparation method of tilmicosin enteric-coated pellets of the present invention comprises:

[0035] The first step is to mix tilmicosin, poloxamer 188 and microcrystalline cellulose evenly, and then mix them with purified water at a solid-liquid weight ratio of 0.9-1.1:1 to obtain a soft material; The material is extruded and spheronized by a spherical extruder and a spheronizer, and then dried to obtain a pellet core; the pellet core is composed of the following components by weight percentage: tilmicosin 20-60%, poloxane Mu 1885-35%, microcrystalline cellulose 20-75%;

[0036] The second step is to sieve the pellet core, take the pellet core whose size is between the sieve aperture of 24 mesh sieve and the aperture of 28 mesh sieve, and set aside; make the coating liquid with the coating material and purified water ,stand-by;

[0037] The third step is to put the micropill core to be used in the fluidized bed, and to coat it with the coating liquid to form a co...

Embodiment 1

[0041] The pellet core of tilmicosin enteric-coated pellets consists of the following components by weight percentage:

[0042] Tilmicosin 30%

[0043] Poloxamer 18835%

[0044] Microcrystalline cellulose 35%;

[0045] The coating layer of tilmicosin enteric-coated pellets consists of the following components by weight percentage:

[0046] Polyacrylic resin 60%

[0047] Triethyl Citrate 10%

[0048] Talc powder 30%;

[0049] The weight of the coating layer accounts for 15-18% of the total weight of the tilmicosin enteric-coated pellets.

[0050] During preparation, firstly mix tilmicosin, poloxamer 188 and microcrystalline cellulose evenly, and then mix them evenly with purified water at a solid-to-liquid weight ratio of 0.9:1 to obtain a soft material; The extruder and spheronizer carry out extrusion and spheronization, and then dry to obtain the pellet core; the pellet core is sieved, and the pellets whose size is between the sieve aperture of 24 mesh sieve and the ape...

Embodiment 2

[0052] Basically the same as Example 1, the difference is:

[0053] The pellet core of tilmicosin enteric-coated pellets consists of the following components by weight percentage:

[0054] Tilmicosin 40%

[0055] Poloxamer 18815%

[0056] Microcrystalline Cellulose 45%;

[0057] The coating layer of tilmicosin enteric-coated pellets consists of the following components by weight percentage:

[0058] Hydroxypropyl Methyl Cellulose 50%

[0059] Triethyl Citrate 15%

[0060] Talc 35%;

[0061] The weight of the coating layer accounts for 18-20% of the total weight of the tilmicosin enteric-coated pellets.

[0062] During preparation, the solid-to-liquid weight ratio when making soft materials is 1:1; set the inlet air temperature of the fluidized bed to 70°C, the outlet air temperature to 50°C, and the fan frequency to 40HZ; After the bed is started, when the temperature of the pellet cores to be used reaches 50°C, spray the coating solution, and maintain the temperature o...

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Abstract

The invention relates to tilmicosin enteric-coated pellets. Each tilmicosin enteric-coated pellet is composed of a pellet core and a coating layer coating the pellet core. Each pellet core is composed of, by weight, 20-60% of tilmicosin, 5-35% of poloxamer 188 and 20-75% of microcrystalline cellulose. The size of the pellet cores is not larger than the mesh aperture of a 24-mesh sieve and not smaller than the mesh aperture of a 28-mesh sieve. The weight of the coating layers accounts for 8-20% of the total weight of the tilmicosin enteric-coated pellets. The invention further relates to a preparation method of the tilmicosin enteric-coated pellets. The tilmicosin enteric-coated pellets can cover the bitter taste of the tilmicosin, the acid stability of the preparation is ensured, and the biological utilization degree is remarkably improved.

Description

technical field [0001] The invention relates to tilmicosin enteric-coated pellets and a preparation method thereof, belonging to the technical field of veterinary drug preparations. Background technique [0002] As far as the inventors know, Tilmicosin (Tilmicosin) is a semi-synthetic macrolide antibiotic for livestock and poultry that was developed by Elanco in the 1980s. It has strong antibacterial activity, low drug resistance, and a broad antibacterial spectrum. It has a wide inhibitory effect on all Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, spirochetes, etc., especially a variety of mycoplasma and spirochetes. The antibacterial activity of tilmicosin is superior to many antibiotics such as tylosin, danofloxacin, oxytetracycline, florfenicol and spectinomycin. Tilmicosin is mainly used to treat infectious diseases in goats, cows, pigs, chickens and other animals, especially respiratory tract infections in livestock and poultry, such as pleuropneum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/16A61K31/706A61K47/38A61K47/34A61P31/04A61K47/10
Inventor 徐瑞华胡娟戴银娣
Owner CHINANIMAL NANJING VETERINARY DRUGS
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