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Breast cancer molecular probe and preparation method thereof

A molecular probe, breast cancer technology, applied in the field of medical imaging, can solve the problems of single fluorescence imaging resolution and sensitivity, and achieve the effect of improving sensitivity and resolution, preventing recurrence and metastasis, and increasing the number and density

Active Publication Date: 2015-04-01
WUXI PEOPLES HOSPITAL
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  • Claims
  • Application Information

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Problems solved by technology

Although the signal components of breast cancer molecular probes can be existing signal components in existing molecular imaging, the present invention takes into account the impact of radiation on the living body, and solves the problem of single fluorescence imaging and single magnetic resonance imaging in terms of resolution and Insufficient in sensitivity, the present invention prefers fluorescence-magnetic resonance dual-modal imaging, that is, the signal component is a signal component that couples fluorescent substances suitable for molecular probes and magnetic resonance imaging substances to form a dual-mode molecule probe

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  • Breast cancer molecular probe and preparation method thereof
  • Breast cancer molecular probe and preparation method thereof
  • Breast cancer molecular probe and preparation method thereof

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Embodiment Construction

[0036] In the following, the present invention will be further described by taking the dual-mode molecular probe as an example in conjunction with the best embodiments, so as to facilitate the understanding of the present invention.

[0037] 1. Preparation of molecular probes

[0038] 1.1 Preparation of paramagnetic quantum dots

[0039] 1.1.1 Preparation of lipophilic quantum dots

[0040] In this example, Zn-Cu-In-S nuclear quantum dots with good monodispersity and high crystallinity were prepared by using group I-III-VI elements (such as copper, indium, sulfur, zinc, etc.) through a high-temperature oil phase method. In order to obtain more photostable quantum dots, the core quantum dots are then coated with a surface inorganic layer (such as ZnS) to improve the fluorescence efficiency and photochemical stability of the core-shell quantum dots. When designing the composition and structure of the shell, it is necessary to comprehensively consider the lattice matching param...

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Abstract

The invention discloses a breast cancer molecular probe, which is composed of a signal component and an affinity component. The breast cancer molecular probe is characterized in that the affinity component is a component for specific combination of breast cancer stem cell targets; and the signal component is composed of a near-infrared fluorescent signal unit and a magnetic resonance signal unit. The preparation method comprises the following steps: coupling the signal function unit with monoclonal antibodies which are specific surface markers of breast cancer stem cells by adopting a chemical covalent coupling method; and purifying. Aiming at the molecular probe which is specifically combined with multiple targets of the breast cancer stem cell targets, in vivo detection and quantitative analysis of the breast cancer stem cells can be solved by virtue of the molecular probe; a basis is provided for a new strategy for imaging diagnosis and targeted treatment therapeutic effect evaluation of solid tumor stem cells; a 'new mode' is provided for early diagnosis and grading of tumors; precise information and an evaluation method are provided for tumor treatment; and a diagnostic information foundation is laid for further solving reappearing and transferring problems.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and specifically relates to a molecular probe, in particular to a breast cancer molecular probe, which is used for medical imaging of breast cancer diagnosis and treatment. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. The incidence rate accounts for 7-10% of all kinds of malignant tumors in the whole body. It is second only to uterine cancer in women and has become the main cause of threat to women's health. It is one of the most common malignant tumors that usually occurs in the glandular epithelial tissue of the breast, seriously affecting women's physical and mental health and even threatening their lives. Breast cancer is rare in men, and only about 1-2% of breast cancer patients are men. [0003] The principle of breast cancer treatment is clinically the first choice for early and mid-stage breast cancer, and radical resection is t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N24/10G01N33/577
Inventor 方向明张兵波胡春洪
Owner WUXI PEOPLES HOSPITAL
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