Self-assembled targeted nanometer drug carrier micelles

Abstract

The present invention discloses self-assembled targeted nanometer drug carrier micelles. The self-assembled targeted nanometer drug carrier micelle preparation method comprises: adopting an atom transfer radical polymerization method to polymerize phosphatidyl choline to obtain poly phosphatidyl choline; modifying the poly phosphatidyl choline with folic acid molecules; adopting a ring-opening polymerization method to polymerize S-benzyl-L-cysteine carboxylic anhydride to obtain poly S-benzyl-L-cysteine; grafting adriamycin on the poly S-benzyl-L-cysteine through a hydrazone bond; bonding the poly phosphatidyl choline and the poly S-benzyl-L-cysteine through a click chemistry method to obtain a block copolymer; respectively dissolving the block polymer in tetrahydrofuran, transferring into a dialysis bag, carrying out dialysis with purified water, and filtering the dialyzed solution with a filtration membrane; and carrying out freeze-drying on the filtered solution to obtain the drug-loaded micelles, wherein the drug carrier micelles have a core-shell double-layer structure, the outer layer is the hydrophilic poly phosphatidyl choline, and the inner layer is the drug molecule wrapping layer. According to the present invention, the material has the following advantages that: the material belongs to the nanoparticles; the targeted drug delivery on the cancer cells and the pH-sensitive drug release in the cancer cells can be achieved; the drug loading is high; the stability is good; and with the targeting function, the toxic-side effect of the drug on the normal tissues and organs can be effectively reduced.

Description

technical field [0001] The invention relates to a self-assembled targeting nano drug carrier micelle, in particular to a preparation method of a block polymer material drug carrier micelle with cancer cell targeting. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Cancer has become the most important disease that endangers human health. One of the important methods to treat cancer is drug therapy. However, many anticancer drugs have defects such as insoluble in water and poor stability. For example, camptothecin, paclitaxel, doxorubicin, and 5-fluorouracil are difficult to be well utilized by organisms due to their poor solubility. Solving the problem of their water solubility is the key to the clinical application of such pharmaceutical preparations. In addition, most of the tumor treatment and diagnostic drugs have non-selective effects, and are often distributed in some normal tissues and organs, and the thera...

AI Technical Summary

Problems solved by technology

[0006] However, due to the complex structure of the polymer in the star polymer, the prepared drug carrier has problems such as poor biocompatibility, decreased drug loading capacity, and reduced water solubility of drug molecules on the surface of dendrimer.

In addition, dendrimer has a complex structure and high synthesis cost

These problems limit the application of star-shaped polymer nano-drug delivery system

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