Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Neferine sublingual spraying agent and preparation method thereof

A technology of nexinine and spray, applied in the field of traditional Chinese medicine, can solve problems such as gastrointestinal side effects, inconvenient use, and unacceptable to patients

Inactive Publication Date: 2015-03-18
宋金春 +2
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a sublingual spray of nexinine, which uses a scientific formula to prepare nexinine as a spray with a polymer material, which can solve the problem of clinical bioavailability of the prior art It has the disadvantages of low intensity, inconvenient use, unacceptable to patients, and certain side effects on the gastrointestinal tract

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Neferine sublingual spraying agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] Take the prescription amount (see Table 1) of liensinine raw material drug and menthol as follows, add the prescription amount of solubilizer, prepare microspheres or microcapsules, shake well, ultrasonically promote dissolution, and then add the prescription amount of ethanol Sonicate or vibrate until completely dissolved, filter, dilute to volume, shake well, dispense into 3 mL sublingual spray bottles, seal and twist the cap, and store in a cool place away from light.

[0013] Table 3 The formula of nerosinine spray

[0014]

[0015] The prescription design of the liensinine spray prepared by the invention is reasonable, the preparation process is simple and convenient, and the product quality can be ensured. The drug delivery device is advanced, the quantification is accurate, the reproducibility is good, and the container is airtight, which provides a guarantee for the successful development of the modified dosage form.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a neferine sublingual spraying agent and a preparation method thereof. The neferine sublingual spraying agent can be quickly absorbed by the sublingual mucosa, can directly enter the blood, is free from liver first-pass effect, is convenient to take, causes less adverse reaction and has a good treatment effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a medicinal dosage form of liensinine in lotus seeds, in particular to a sublingual spray and a preparation method thereof. [0002] Background technique [0003] Neferine (Nef) is a bisbenzylisoquinoline alkaloid (molecular formula C 38 h 44 N 2O6 ). It has been proved by pharmacological experiments and clinical application that it can lower blood pressure, resist arrhythmia, inhibit platelet aggregation, resist oxidation and scavenge active free radicals, resist myocardial ischemia, relax smooth muscle, strengthen the heart, resist cancer, protect against cerebral ischemic damage, Improve acute lung injury and pulmonary fibrosis, central inhibition, hypoglycemia, etc., and can be used as an antiarrhythmic drug with rapid clinical effect, so it is suitable to be prepared into quick-acting preparations (such as sublingual preparations, preparations for inje...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/4725A61P9/06
Inventor 宋金春宋杨一嫣彭燕
Owner 宋金春
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com