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Material for preparing artificial bones and preparation method thereof

An artificial bone and raw material technology, applied in the field of medical supplies, can solve the problems of high tensile strength, high elongation at break, and high corrosion resistance, and achieve high tensile strength, high elongation at break, and corrosion resistance. high performance effects

Active Publication Date: 2015-03-11
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem to be solved: Aiming at the shortcomings of existing artificial bone materials, the present invention provides a material for preparing artificial bone and a preparation method thereof. The material has high elongation at break, high tensile strength, good wear resistance, high corrosion resistance, easy molding, and good biocompatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A material for preparing artificial bone, comprising the following raw materials in parts by mass: 5 parts of vinyl silicone rubber, 0.8 parts of hydroxy silicone oil, 2.5 parts of meteorological white carbon black, 3 parts of chitin, 2 parts of hydroxyapatite, 1 part of phosphoric acid, 0.6 part of bone morphogenic protein, 0.4 part of calcium hydroxide, 0.5 part of nanocellulose.

[0015] A preparation method for preparing artificial bone materials, comprising the steps of: mixing vinyl silicone rubber, hydroxysilicone oil, meteorological white carbon black, chitin, hydroxyapatite, phosphoric acid, bone morphogenic protein, calcium hydroxide and nanofibers Add the element into an extruder to melt and blend for 8 minutes, and extrude at a temperature of 200° C. to prepare the material for artificial bone.

Embodiment 2

[0017] A material for preparing artificial bone, comprising the following raw materials in parts by mass: 15 parts of vinyl silicone rubber, 2.2 parts of hydroxy silicone oil, 4.5 parts of meteorological white carbon black, 10 parts of chitin, 7 parts of hydroxyapatite, 4 parts of phosphoric acid, 1.8 parts of bone morphogenic protein, 1 part of calcium hydroxide, 1.2 parts of nanocellulose.

[0018] A preparation method for preparing artificial bone materials, comprising the steps of: mixing vinyl silicone rubber, hydroxysilicone oil, meteorological white carbon black, chitin, hydroxyapatite, phosphoric acid, bone morphogenic protein, calcium hydroxide and nanofibers Add the element into an extruder to melt and blend for 15 minutes, and extrude at a temperature of 230° C. to prepare the artificial bone material.

Embodiment 3

[0020] A material for preparing artificial bone, comprising the following raw materials in parts by mass: 8 parts of vinyl silicone rubber, 1 part of hydroxy silicone oil, 3 parts of meteorological white carbon black, 5 parts of chitin, 3 parts of hydroxyapatite, 1.5 parts of phosphoric acid, 1 part of bone morphogenic protein, 0.5 parts of calcium hydroxide, and 0.6 parts of nanocellulose.

[0021] A preparation method for preparing artificial bone materials, comprising the steps of: mixing vinyl silicone rubber, hydroxysilicone oil, meteorological white carbon black, chitin, hydroxyapatite, phosphoric acid, bone morphogenic protein, calcium hydroxide and nanofibers Add the element into an extruder to melt and blend for 8 minutes, and extrude at a temperature of 200° C. to prepare the material for artificial bone.

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PUM

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Abstract

The invention provides a material for preparing artificial bones and a preparation method thereof. The material comprises the following raw materials in parts by weight: 5 to 15 parts of vinyl silicone rubber, 0.8 to 2.2 parts of hydroxy silicone oil, 2.5 to 4.5 parts of fumed silica, 3 to 10 parts of chitin, 2 to 7 parts of hydroxy apatite, 1 to 4 parts of phosphoric acid, 0.6 to 1.8 parts of bone morphogenetic protein, 0.4 to 1 part of calcium hydroxide, and 0.5 to 1.2 parts of nano cellulose. The provided material has the advantages of large break elongation rate, high tensile strength, good wear resistant property, good corrosion resistant performance, easiness in moulding, and good biocompatibility.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to a material for preparing artificial bone and a preparation method thereof. Background technique [0002] Artificial bone refers to a human bone substitute or fracture fixation material made of artificial materials. Such as hydroxyapatite, alumina bioceramics, etc., can replace human skull, shoulders, arms, fingers, fat joints, etc. It is easy to process, cheap and high-quality, and has little aging and corrosion in the body, but has poor wear resistance. At the same time, when the artificial bone heals with the living body and bears heavy external force, bone resorption will occur, resulting in the detachment of human bone. [0003] An ideal artificial bone composite should have good biocompatibility and biodegradability, and be able to promote the generation of new bone cells. [0004] Tricalcium phosphate artificial bone material is one of the most researched and applied bone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/12A61L27/02A61L27/50
Inventor 潘林根邱东成刘乐峰
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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