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Indapamide slow release medicine containing composite lactose

A technology for indapamide and sustained-release drugs, applied in the field of medicine, can solve the problems of large limitations, high cost, poor mixing uniformity, etc., and achieve the effects of improving production efficiency, reducing production energy consumption, and achieving good uniformity.

Active Publication Date: 2015-03-11
HUANGSHAN C KING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, wet granulation has many defects: the formula contains a large amount of HPMC, and when water is used as a wetting agent or binder for granulation, HPMC will quickly form very viscous gel groups of different sizes, which will wrap part of the dry powder Including, causing problems of poor mixing uniformity and uneven release
The process is relatively harsh, and the main drug needs to be micronized, which has high cost and relatively large limitations.

Method used

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  • Indapamide slow release medicine containing composite lactose
  • Indapamide slow release medicine containing composite lactose
  • Indapamide slow release medicine containing composite lactose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In the first embodiment, the skeleton material is hydroxypropyl methylcellulose K4M, and the lubricant is 0.3% silica gel and 0.75% magnesium stearate;

Embodiment 2

[0036] In the second embodiment, the skeleton material is hydroxypropyl methylcellulose K4M, and the lubricant is 0.3% silica gel and 0.75% magnesium stearate;

Embodiment 3

[0037] In the third embodiment, the skeleton material is hydroxypropyl methylcellulose K4M, and the lubricant is 0.3% silica gel and 0.75% magnesium stearate;

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PUM

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Abstract

The invention relates to a preparation method of an indapamide slow release medicine in order to improve the slow release performance of the medicine. The medicine comprises 0.5-2wt% of indapamide, 30-50wt% of a skeletal material, 14-28wt% of 100 mesh lactose, 20-35wt% of 200 mesh lactose, 10-20wt% of polyvinylpyrrolidone K30 and 0.2-2wt% of a lubricant. The medicine is prepared by adopting a powder direct pressing technology, and has the advantages of uniform distribution of a main medicine in a tablet, god tablet uniformity (uniformity index control needed by low content tablets), avoiding of the influences of water, heating and drying brought by traditional preparation technologies on the quality of the main medicine in the preparation process, production energy consumption reduction, and production efficiency increase.

Description

Technical field [0001] The invention relates to the field of medicine, in particular to indapamide sustained-release medicine and a preparation method. Background technique [0002] Indapamide is a non-thiazide indole derivative with dual effects of lowering blood pressure and diuresis. Its low-dose antihypertensive effect is obvious; it is quickly absorbed after oral administration, binds to plasma proteins, and selectively concentrates on vascular smooth muscle. It inhibits the inward calcium ion flow of cells, reduces vasoconstriction, and the reactivity of blood vessels to pressure-increasing substances. So that the vascular resistance is reduced, thereby producing antihypertensive activity. Indapamide has been widely used in the treatment of hypertension. [0003] The indapamide sustained-release tablets currently used are usually small-dose sustained-release preparations containing 1.5 mg of indapamide. The 1.5 mg sustained-release indapamide greatly improves the effect / sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/404A61K47/26A61K47/38A61K47/34A61P9/12A61P7/10
Inventor 司鹏付杰周世文
Owner HUANGSHAN C KING PHARMA
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