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Chinese herbal medicine solid-phase extraction column and sample pretreatment method for detecting Chinese herbal medicine pesticide residues

A solid-phase extraction column and sample pretreatment technology, which is used in the field of medicine and agricultural product safety testing, can solve the problems of inapplicability to extract and purify pesticide residues at the same time, achieve ideal recovery rate, save experimental operation time, and meet the effect of determination requirements.

Active Publication Date: 2016-03-09
天津博纳艾杰尔科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Finally, none of the above-mentioned existing patented methods are suitable for simultaneous extraction and purification of more than 400 pesticide residues from Chinese herbal medicines

Method used

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  • Chinese herbal medicine solid-phase extraction column and sample pretreatment method for detecting Chinese herbal medicine pesticide residues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Use a high-density polyethylene column tube with a volume capacity of 6mL or 12mL. One end of the column tube 1 is the sample or solvent injection port 4, and the other end is the sample or solvent outflow port 5, which is filled with graphitized carbon and amino-bonded silica gel. , three octadecyl-bonded silica materials, in which amino-bonded silica and octadecyl-bonded silica are mixed as a layer 2, graphitized carbon is used as a layer 3, and a polypropylene sieve plate 6 with a pore size of 20 μm is used as a layer Separation, both ends of the filler are sealed by sieve plates, filled with two layers of three-material mixed purification column, graphitized carbon, amino-bonded silica gel and octadecyl-bonded silica gel in the Chinese herbal solid-phase extraction column The mass ratio is 6:3:1, and the graphitized carbon is packed at the bottom of the column tube. Among them, the particle size of graphitized carbon material ranges from 80 mesh to 200 mesh, and the...

Embodiment 2

[0043] Use a high-density polyethylene column tube with a volume capacity of 6mL or 12mL. One end of the column tube 1 is the sample or solvent injection port 4, and the other end is the sample or solvent outflow port 5, which is filled with graphitized carbon and amino-bonded silica gel. , three octadecyl-bonded silica materials, in which amino-bonded silica and octadecyl-bonded silica are mixed as a layer 2, graphitized carbon is used as a layer 3, and a polypropylene sieve plate 6 with a pore size of 20 μm is used as a layer Separation, both ends of the filler are sealed by sieve plates, filled with two layers of three-material mixed purification column, graphitized carbon, amino-bonded silica gel and octadecyl-bonded silica gel in the Chinese herbal solid-phase extraction column The mass ratio is 8:5:1, and the graphitized carbon is packed at the bottom of the column tube. Among them, the particle size of graphitized carbon material ranges from 80 mesh to 300 mesh, and the...

Embodiment 3

[0045] Use a glass column tube with a volume capacity of 6mL or 12mL. One end of the column tube 1 is the sample or solvent injection port 4, and the other end is the sample or solvent outflow port 5, which is filled with graphitized carbon, amino-bonded silica gel, eighteen Three materials of alkyl bonded silica gel, in which amino bonded silica gel and octadecyl bonded silica gel are mixed as a layer 2, graphitized carbon is used as a layer 3, and polypropylene sieve plate 6 with a pore size of 20 μm is used as a separator, and the filler The two ends of the sieve plate are sealed and filled with two layers of three materials mixed purification columns. The mass ratio of graphitized carbon, amino-bonded silica gel and octadecyl-bonded silica gel in the Chinese herbal medicine solid-phase extraction column is The ratio is 3:8:1, where the graphitized carbon is packed at the bottom of the column tube. Among them, the particle size distribution of graphitized carbon materials r...

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Abstract

The invention discloses a Chinese herbal medicine solid-phase extraction column. The Chinese herbal medicine solid-phase extraction column comprises a column tube and a packing in the column tube, wherein the packing is composed of the following components in parts by weight: 2-10 parts of carbon materials, 2-10 parts of amino-functionalized adsorbing materials and 1 part of silica gel material modified by a non-polar functional group; the carbon materials are fed in a bottom layer of the column tube; the amino-functionalized adsorbing materials and the silica gel material modified by the non-polar functional group are fed in an upper layer of the column tube in a mixing manner. The invention further discloses a sample pretreatment method for detecting pesticide residues in Chinese herbal medicines by using the Chinese herbal medicine solid-phase extraction column. The Chinese herbal medicine solid-phase extraction column is applied to sample pretreatment, can be used for analyzing and detecting pesticides and metabolic products in four Chinese herbal medicines namely ramulus mori, flos lonicerae, fructus lycii and folium nelumbinis, and has the characteristics that a sample is treated at one time; more than 400 pesticide residues in the Chinese herbal medicines are extracted and purified; the Chinese herbal medicine solid-phase extraction column is quick, economic and high in generality.

Description

technical field [0001] The invention relates to the field of medicine and agricultural product safety detection. More specifically, it relates to a Chinese herbal medicine solid-phase extraction column and a sample pretreatment method for detecting Chinese herbal medicine pesticide residues. Background technique [0002] In recent years, the demand for natural medicines in the world has been increasing, especially for green medicines. And Chinese herbal medicine is the treasure of our Chinese nation, has the long history of thousands of years. my country has abundant natural medicinal resources, which provide abundant raw materials for the production of traditional Chinese medicine in our country. However, the quality and safety problems in the production of traditional Chinese medicine restrict the development of traditional Chinese medicine in our country. Pesticide residues are a prominent problem in the quality and safety of traditional Chinese medicine. According to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/22B01D15/20G01N1/34G01N1/40
Inventor 庞国芳汪群杰曹彦忠胡雪燕黄韦范春林
Owner 天津博纳艾杰尔科技有限公司
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