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Method for preparing traditional Chinese medicine preparation for angina pectoris

A technology for traditional Chinese medicine preparations and angina pectoris, which is applied in the field of preparation of traditional Chinese medicine preparations, can solve problems such as failure to achieve effects, and achieve the effects of peaceful drug properties, wide drug sources and high bioavailability

Inactive Publication Date: 2015-01-28
邵明涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are new drugs for the treatment of angina pectoris in clinical practice, including western medicine and Chinese patent medicine and new interventional treatment methods, but these have failed to achieve truly satisfactory results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A Chinese patent drug preparation for angina pectoris, characterized in that it is prepared from the following raw materials in weight ratio

[0032] 40 parts of astragalus, 35 parts of scallion, 35 parts of centella asiatica, 30 parts of gardenia, 30 parts of geranium,

[0033] 28 parts of Radix Paeoniae Rubra, 28 parts of Panax notoginseng, 25 parts of Chuanxiong, 25 parts of Dijincao, 25 parts of Wulingzhi,

[0034] 22 parts of daylily, 22 parts of Danshen, 20 parts of Divine Comedy, 20 parts of Ligustrum lucidum, 20 parts of Polygonatum odoratum,

[0035] 18 parts of Puhuang, 18 parts of Huai Mi, 15 parts of Polygonum cuspidatum, 15 parts of Forsythia, 15 parts of Albizia Julibrissin,

[0036] 10 parts of Magnolia officinalis, 10 parts of curcuma, 7 parts of ginkgo biloba, 7 parts of nutmeg, and 5 parts of nux.

[0037] The specific operation steps of its preparation method of Chinese patent medicine preparation of the present invention are:

[0038] 1) Take each...

Embodiment 2

[0045] clinical experiments

[0046] Anti-hypoxia experiment

[0047] 1. Animals:

[0048] Test animals: healthy mice 20-25g

[0049] 2. Drugs and reagents:

[0050]Test drug, the drug prepared in Example 1; positive control drug: propranolol, provided by Tianjin Lisheng Pharmaceutical Co., Ltd.; isoproterenol hydrochloride, provided by Shanghai Hefeng Pharmaceutical Co., Ltd.

[0051] 3. Experimental method:

[0052] 60 mice were randomly divided into 3 groups, 20 in each group. The model group was given normal saline by intragastric administration, the experimental group was given 20 mg / kg of the pharmaceutical composition prepared in the embodiment, and the positive control group was given 20 mg / kg of propranolol. After gavage for 1 hour, the normal group was subcutaneously injected with equal volume of normal saline, and the other groups were subcutaneously injected with isoproterenol hydrochloride 20 mg / kg. After 15 minutes, they were put into a 250 mL jar containing ...

Embodiment 3

[0061] clinical information

[0062] Select 76 patients diagnosed with angina pectoris and divide them into two groups randomly. The treatment group consisted of 38 cases, including 21 males and 17 females, aged 52 to 78 years, with a course of disease ranging from 6 months to 4 years. There were 38 cases in the control group, including 22 males and 16 females, aged 49 to 76 years, with a course of 5 months to 4 years. There was no significant difference in gender, age, and course of disease between the two groups before treatment (P>0.05). comparability.

[0063] Diagnostic criteria

[0064] Western medicine diagnostic criteria

[0065] Refer to "Suggestions for the Diagnosis and Treatment of Unstable Angina Pectoris" by the Cardiovascular Disease Branch of the Chinese Medical Association.

[0066] Diagnosis and Syndrome Differentiation Standards of TCM

[0067] The TCM syndrome differentiation standard for coronary heart disease revised in 1990 was used for TCM syndrom...

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PUM

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Abstract

The invention relates to a method for preparing a traditional Chinese medicine preparation for angina pectoris. The preparation is prepared by the following raw materials: radix astragali, allium macrostemon, centella, jasmine, tabasheer, paeonia veitchii, pseudo-ginseng, ligusticum wallichii, humifuse euphorbia herb, trogopterus dung, day lily, the root of red-rooted salvia, medicated leaven, glossy privet fruit, radix polygonati officinalis, pollen typhae, sophora flower bud, Polygonum cuspidatum, fructus forsythiae, albizia flower, Mangnolia officinalis, curcuma zedoary, ginkgo leaf, nutmeg and semen strychni. The medicine composition prepared by the method provided by the invention has an exact curative effect on the angina pectoris and has the advantages of no side effect, low price, high simplicity and convenience in manufacture and broad application prospect.

Description

[0001] technical field [0002] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of a traditional Chinese medicine preparation for angina pectoris. Background technique [0003] Angina pectoris is a group of clinical symptoms mainly manifested by paroxysmal chest pain or chest discomfort caused by coronary artery atherosclerosis and / or coronary artery functional changes (spasm) leading to coronary artery insufficiency, myocardial ischemia and hypoxia. syndrome. It belongs to the category of "chest pain and heart pain" in traditional Chinese medicine. Traditional Chinese medicine believes that toxins in the body, heart and kidney qi and yang are insufficient, resulting in a lack of chest yang. Internal injuries of the seven emotions lead to qi stagnation. Irregular diet, overwork, damage the spleen and stomach, and produce turbid phlegm. Cold evil attacks from outside, causing cold to doubt th...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P9/10
CPCA61K36/481A61K35/24A61K36/16A61K36/185A61K36/23A61K36/236A61K36/258A61K36/47A61K36/48A61K36/489A61K36/537A61K36/56A61K36/575A61K36/634A61K36/638A61K36/65A61K36/704A61K36/71A61K36/744A61K36/88A61K36/896A61K36/8962A61K36/8969A61K36/899A61K36/9066A61K2236/15A61K2236/19A61K2236/333A61K2236/39
Inventor 邵明涛魏京军
Owner 邵明涛
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