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Temperature-sensitive and photosensitive dual-response polypeptide based host-guest composite intelligent hydrogel as well as preparation method and application thereof

A hydrogel, subject-guest technology, applied in the direction of pharmaceutical formulations, non-active ingredients of polymer compounds, medical preparations of non-active ingredients, etc., can solve the problem of insufficient biocompatibility and insufficiently obvious mutual conversion effect in the macroscopic view and other issues to achieve the effect of good biocompatibility

Inactive Publication Date: 2015-01-21
EAST CHINA NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this hydrogel system is a single-stimuli-responsive smart hydrogel that responds to light stimuli, and the interconversion effect between sol-gel is not obvious enough macroscopically, and the biocompatibility of the system is not good enough.

Method used

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  • Temperature-sensitive and photosensitive dual-response polypeptide based host-guest composite intelligent hydrogel as well as preparation method and application thereof
  • Temperature-sensitive and photosensitive dual-response polypeptide based host-guest composite intelligent hydrogel as well as preparation method and application thereof
  • Temperature-sensitive and photosensitive dual-response polypeptide based host-guest composite intelligent hydrogel as well as preparation method and application thereof

Examples

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preparation example Construction

[0043] A method for preparing a temperature-sensitive and photosensitive-responsive polypeptide-based host-guest composite intelligent hydrogel of the present invention comprises the following steps:

[0044] (1) Preparation of graft polymer PELG-g-(PNIPAM / β-CD)

[0045] Using L-glutamic acid and chloroethanol as initial raw materials to prepare PELG-N with azido side group by NCA (α-amino acid-N-carboxyl internal acid anhydride) ring-opening polymerization and azidation reaction 3 , and then click chemical reaction was used to add pre-prepared poly N-isopropylacrylamide (PNIPAM) (1.00g, 0.238mmol) containing alkyne terminal group, cyclodextrin functional molecule (mono -6-Propargyl-β-CD) (0.12g, 0.102mmol), PELG-N3 (0.052g) and 10mL DMF, stir well, then add CuBr (0.041g, 0.28mmol) and ligand PMDETA under nitrogen atmosphere (60 μL). Keep the reaction at 50°C for 72 hours. The reaction was stopped, DMF was spin-dried, dichloromethane was added, the organic phase was concent...

Embodiment 1

[0052] Example 1 Preparation of graft polymer PELG-g-(PNIPAM / β-CD)

[0053] The preparation process of this embodiment is as shown in the following formula (3):

[0054]

[0055] Using L-glutamic acid and chloroethanol as initial raw materials to prepare PELG-N with azido side group by NCA (α-amino acid-N-carboxyl internal acid anhydride) ring-opening polymerization and azidation reaction 3 , and then click chemical reaction was used to add pre-prepared poly N-isopropylacrylamide (PNIPAM) (1.00g, 0.238mmol) containing alkyne terminal group, cyclodextrin functional molecule (mono -6-Propargyl-β-CD) (0.12g, 0.102mmol), PELG-N3 (0.052g) and 10mL DMF, stir well, then add CuBr (0.041g, 0.28mmol) and ligand PMDETA under nitrogen atmosphere (60 μL). Keep the reaction at 50°C for 72 hours. The reaction was stopped, DMF was spin-dried, dichloromethane was added, the organic phase was concentrated, precipitated in ether, filtered by suction, and collected by vacuum drying to obtai...

Embodiment 2

[0057] Example 2 Preparation of temperature-sensitive and photosensitive dual-response polypeptide-based host-guest composite smart hydrogel

[0058] The graft polymer PELG-g-(PNIPAM / β-CD) prepared in Example 1 and the second-generation dendrimer (Me-G 2-Azo) was dissolved in water and mixed to prepare a sol. When the temperature of the system rises to 40°C, the sol turns into a hydrogel, and when the temperature returns to room temperature, the gel breaks and returns to the sol state. When the temperature of the system rises to 60°C, precipitation occurs at the bottom, and no gel can be formed. When the temperature returns to room temperature, the system turns into a sol again, and the temperature-sensitive stimulus-responsive polypeptide-based host-guest composite smart hydrogel is obtained. The method for identifying the obtained photosensitive hydrogel is: invert the sample bottle for 5 minutes, the system can overcome the gravity and be in a stable state without any flow...

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Abstract

The invention discloses a temperature-sensitive and photosensitive dual-response polypeptide based host-guest composite intelligent hydrogel and a preparation method thereof. The preparation method comprises the following steps: dissolving a graft polymer PELG-g-(PNIPAM / beta-CD) modified by poly(N-isopropylacrylamide) and beta-cyclodextrin together and second generation dendritic molecules (Me-G2-Azo) modified by azobenzene into water, and mixing to prepare a sol. The temperature-sensitive and photosensitive dual-response polypeptide based host-guest composite intelligent hydrogel disclosed by the invention has stimulation response properties to temperature and light, is easy to prepare, and has wide application prospects in the fields of temperature control and optical control switches, temperature control and optical control motors and temperature control and optical control medicament release.

Description

technical field [0001] The invention belongs to the technical field of new materials, specifically relates to an intelligent polymer material technology, and more specifically relates to a temperature-sensitive and photosensitive double-responsive polypeptide-based host-guest composite intelligent hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a very important class of soft matter materials, which has broad application prospects in various fields, and the research on hydrogel has attracted more and more attention from researchers in recent years. Cyclodextrin supramolecular hydrogel is a new research field in recent years. In addition to the basic properties of general hydrogels, such as biocompatibility, high water content, and non-inactivation of drug loading, it also has unique self-assembly and molecular recognition properties, showing good intelligent responsiveness, such as temperature , light, pH value and other stimuli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L87/00C08G81/02C08G69/10C08B37/16C08F120/54C08F8/18A61K47/34A61K47/40
Inventor 贺小华张莉莉朱海岭胡超群林紹梁
Owner EAST CHINA NORMAL UNIV
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