Preparation method of cold heat clearing granules

Abstract

The invention discloses a preparation method of cold heat clearing granules. The preparation method comprises the following steps: firstly, mixing schizonepeta spike, mint and perilla leaf, grinding and dipping the mixture through an ethanol water solution, percolating, extracting percolate through diethyl ether, decomposing and recovering extract liquor to obtain an extract I; then, mixing divaricate saposhnikovia root, radix bupleuri, root of kudzu vine, platycodon grandiflorum, semen armeniacae amarae, radix angelicae, bunge corydalis herb and rhizoma phragmitis, grinding and decocting the mixture in water, filtering, mixing filtrates, adsorbing the mixed filtrate through macro-porous adsorption resin, eluting through an ethanol water solution, filtering an eluent through an ultrafiltration membrane, condensing and drying to obtain an extract II; and then, adding beta-cyclodextrin to distilled water, wetting and heating to obtain a beta-cyclodextrin water liquid; and finally, adding the extract I and the extract II to the beta-cyclodextrin water liquid, stirring, spray-drying and granulating, mixing and granulating obtained granules with a thinner, a flavoring agent and a wetting agent to obtain the granules. The method disclosed by the invention not only simplifies a technological process and shortens a production cycle, but also improves a recovery rate of active ingredients and stability of the granules.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and specifically relates to a preparation method of Ganmao Qingre granules. Background technique [0002] Cold is divided into common cold and influenza. The common cold, called "cold" in Chinese medicine, is a common respiratory disease caused by a variety of viruses. Although the common cold mostly occurs in early winter, it can also occur in any season, such as spring and summer. The pathogenic viruses of colds in different seasons are not exactly the same. Influenza is an acute respiratory infectious disease caused by influenza virus. The virus is present in the respiratory tract of the patient, and it is transmitted to others through droplets when the patient coughs or sneezes. Cold is an extremely common and extremely harmful disease. A person who suffers from body aches, weakness, and high fever can be called a bad cold. [0003] The first edition of the Chi...

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Problems solved by technology

In the above method, the decoction method is used to extract the active ingredients of the medicinal materials, which has the disadvantages of long extraction time, high extraction temperature, high energy consumption, easy loss of heat-sensitive ingredients, low recovery rate of active ingredients, troublesome post-processing, etc.

[0004] The prior art teaches β-cyclodextrin inclusion technology, which is mainly used in the inclusion of chemicals and volatile oils in pharmaceuticals to increase the solubility and stability of drugs, improve the bioavailability of drugs, and reduce the irritation of drugs , toxic and side effects, masking of bitter taste, and powdering of liquid drugs, etc., but it has not been applied to the inclusion of Chinese herbal medicine extracts