Preparation method of CaO-SiO2-CuO/PAA (porous anode alumina) composite biological membrane material

A cao-sio2-cuo, biofilm technology, applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulations, etc., can solve the problems of bacterial death, microbial loss of division and proliferation, interference with DNA synthesis, etc., to achieve the method Fast, promotes osteoblast growth, good antibacterial effect

Inactive Publication Date: 2015-01-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, copper ions may interfere with the synthesis of DNA in microorganisms, causing the microorganisms to lose their ability to divide and proliferate, thus causing the bacteria to die

Method used

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  • Preparation method of CaO-SiO2-CuO/PAA (porous anode alumina) composite biological membrane material
  • Preparation method of CaO-SiO2-CuO/PAA (porous anode alumina) composite biological membrane material
  • Preparation method of CaO-SiO2-CuO/PAA (porous anode alumina) composite biological membrane material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] (1) SiO 2 Preparation of sol: Mix 10.65ml of deionized water with 0.1ml of 2mol / L nitric acid, stir to make it uniform, then add dropwise the aqueous solution acidified by nitric acid to 21.32ml of tetraethyl orthosilicate while stirring, Continued to form SiO 2 Sol; (the volume ratio of ethyl orthosilicate, deionized water and nitric acid is 1:0.5:0.005)

[0066] (2) Mix 31.9ml of 0mol / L copper nitrate solution with 60ml of 2mol / L calcium nitrate solution, and stir to make it evenly mixed;

[0067](3) Slowly add the mixed solution of copper and calcium nitrate to the SiO in (1) 2 In the sol, keep magnetic stirring to make it fully react for 65 minutes, and the reaction temperature is controlled at 20°C; (CaO-SiO 2 -The mass percent of CuO three components is 55:46:0)

[0068] (4) Place the PAA film with a pore size of 200nm in the above-prepared sol and perform ultrasonic treatment for 15 minutes, then transfer it to a vacuum drying oven, and maintain it for 30 min...

Embodiment 2

[0078] (1) SiO 2 Preparation of sol: Mix 13.7ml of deionized water with 0.15ml of 2mol / L nitric acid, stir to make it uniform, then add dropwise the aqueous solution of nitric acid acidification to 15.8ml of orthosilicate methyl ester while stirring. continuation, eventually forming SiO 2 Sol; (the volume ratio of methyl orthosilicate, deionized water and nitric acid is 1:0.87:0.009)

[0079] (2) Mix 32.2ml of 0.1mol / L copper nitrate solution with 40ml of 3mol / L calcium nitrate solution, and stir to make it evenly mixed;

[0080] (3) Slowly add the mixed solution of copper and calcium nitrate to the SiO in (1) 2 In the sol, keep magnetic stirring to make it fully react for 40 minutes, and the reaction temperature is controlled at 30 °C; (CaO-SiO 2 -The mass percent of CuO three components is 50:40:2)

[0081] (4) Place the PAA film with a pore size of 200nm in the above-prepared sol and transfer it to a vacuum drying oven for ultrasonic treatment for 15 minutes, then trans...

Embodiment 3

[0090] (1) SiO 2 Preparation of sol: mix 26.6ml of deionized water with 0.29ml of 2mol / L nitric acid, stir to make it uniform, then add dropwise the aqueous solution acidified by nitric acid to 26.6ml of tetraethyl orthosilicate while stirring, Continued to form SiO 2 Sol; (the volume ratio of ethyl orthosilicate, deionized water and nitric acid is 1:1:0.01)

[0091] (2) Mix 8.81ml of 0.2mol / L copper nitrate solution with 30ml of 4mol / L calcium nitrate solution, and stir to make it evenly mixed;

[0092] (3) Slowly add the mixed solution of copper and calcium nitrate to the SiO in (1) 2 In the sol, keep magnetic stirring to make it fully react for 50 minutes, and the reaction temperature is controlled at 40°C; (CaO-SiO 2 -The mass percent of CuO three components is 45:55:3)

[0093] (4) Place the PAA film with a pore size of 250nm in the above-prepared sol and transfer it to a vacuum oven for 4 hours at a relative vacuum of 0.1MPa;

[0094] (5) Take out the obtained sampl...

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Abstract

The invention relates to a preparation method of a CaO-SiO2-CuO / PAA (positive anode alumina) composite biological membrane material. The preparation method of the CaO-SiO2-CuO / PAA composite biological membrane material comprises the following steps: firstly preparing CaO-SiO2-CuO sol by adopting an ultrasonic assisted sol-gel method, then loading the CaO-SiO2-CuO sol into nano pore passages of PAA under the ultrasonic and pressure induced conditions, drying, and roasting, so that the CaO-SiO2-CuO / PAA composite biological membrane material is obtained. The preparation method of the CaO-SiO2-CuO / PAA composite biological membrane material has the advantages that CaO-SiO2-CuO bioactive particles are successfully loaded in the nano pore passages of PAA, a bioactive surface which has bone-like apatite deposition inducing capability and also has effective antibacterial property and excellent cytocompatibility is constructed, and the bioactive surface is expected to be applied to the field of hard tissue repairing materials as a novel artificial implant material surface coating.

Description

technical field [0001] The invention relates to the field of preparation of antibacterial bioactive materials, in particular to a CaO-SiO 2 -The preparation method of CuO / PAA composite biofilm material. Background technique [0002] Porous anodic aluminum oxide (PAA) film is an aluminum oxide film with a highly regular pore structure formed on the surface of pure aluminum by electrochemical oxidation. PAA film has good chemical stability, excellent wear resistance and anti-corrosion performance, and has good biological safety and no toxic side effects after implantation in the body, so it is gradually introduced into the field of biomaterials. Recent research results show that PAA has good biocompatibility and is a potential biomedical material. In addition, PAA has a large-area hexagonal nanopore structure parallel to each other, high specific surface area, uniform and controllable pore size distribution, so it can be used as an excellent carrier for biologically active s...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K33/34A61L27/42A61L27/56A61L27/54A61P31/04A61P1/02
Inventor 倪似愚李长艳杨朋安李晓宏于晓伟
Owner DONGHUA UNIV
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