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Estrogen-free rana japonica oil and preparation method thereof

A technology of wood frog oil and estrogen, which is applied in the field of traditional Chinese medicinal materials and can solve problems such as limiting the scope of application

Active Publication Date: 2015-01-07
通化鑫业生物科技研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the high level of estrogen in Rana oil, it needs to consider the user's hormone level when using it, which limits its application range

Method used

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  • Estrogen-free rana japonica oil and preparation method thereof

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Embodiment Construction

[0017] The dried toad oil of 10Kg is beaten into 30-60 order coarse powder with a traditional Chinese medicine pulverizer, and is used for following processing.

[0018] Take 10Kg of toad oil coarse powder, put it into a 100-liter extraction tank, add 80 liters of ethyl acetate, stir and extract at 50°C for 2 hours, release the extract, and filter the extract through a plate frame. Extract 4 times as above. The filtered extracts were combined and concentrated to dryness in vacuo at 70°C. The extracted toad oil coarse powder was vacuum-filtered at 50° C. for 24 hours to obtain dried toad oil coarse powder. The extract concentrate was dissolved in 800ML ethyl acetate, 600 grams of 100-200 mesh chromatography silica gel was added to mix the sample, and the solvent was evaporated to dryness at room temperature. Another 6 kg of 200-300 mesh chromatography silica gel was dry-packed into a chromatographic column (diameter 20 cm, height 100 cm), and eluted with a gradient of n-hexan...

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Abstract

The invention discloses estrogen-free rana japonica oil and a preparation method thereof. The estrogen-free rana japonica oil is obtained through the following steps: rana japonica oil extraction through acetic acid C1-C6 alkyl ester, C1-C4 fatty alcohol, or solutions such as chloroform, dichloromethane, diethyl ether and acetone, concentration, chromatographic separation, and combined drying. The preparation method provided by the invention is simple; the obtained rana japonica oil can be used for the development of drugs, food and healthcare food for user groups with high estrogen levels.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to an estrogen-free wood frog oil and a preparation method thereof. Background technique [0002] Rana oil, commonly known as Hashi toad oil, is obtained by collecting and drying the oviducts of the female frog of Rana chinensis. Rana oil mainly contains biologically active factors such as protein, polysaccharide, lipid, various inorganic elements, vitamins and various compound polypeptides, and is especially rich in three sex hormones, namely estradiol, testosterone and progesterone. Modern medical research shows that Rana oil has various pharmacological health care functions such as anti-fatigue, anti-aging, and regulating human endocrine; it can promote premature follicle maturation and follicle proliferation, and has a significant impact on sexual cycle; Essence and antipyretic effect, can cure deficiency of essence and blood, weakness of body and qi, cough due to lung deficien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A23L1/29A61P5/28A23L33/00
CPCA23V2002/00A61K35/56A23V2200/30A23V2250/204
Inventor 徐从立
Owner 通化鑫业生物科技研发有限公司
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