Oral multi-vitamin nano liposome

A technology of complex vitamins and nano-liposomes, which is applied in the direction of liposome delivery, drug combination, active ingredients of hydroxyl compounds, etc., can solve the problems of low bioavailability, poor water solubility, etc., to ensure stability, improve absorption rate and The effect of bioavailability

Inactive Publication Date: 2015-01-07
李明刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For fat-soluble vitamins A, D, E, and K, their bioavailability is low due to their poor water solubility

Method used

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  • Oral multi-vitamin nano liposome

Examples

Experimental program
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Effect test

Embodiment 1

[0011] The specific preparation method of the complex vitamin nanoliposome oral liquid provided by the embodiment of the present invention 1 is as follows:

[0012] S01: Weigh 5g of soybean lecithin, 1g of cholesterol, and 1g of Tween 80, add 30ml of absolute ethanol (or chloroform, methanol or methylene chloride, etc.), then put it into an eggplant-shaped bottle, and place it on a water bath evaporator (water bath temperature 40°C±1°C), stir until dissolved to obtain solution a;

[0013] S02: Put 5ml of olive oil into a container and add 50mg of vitamin A to it 1 , 0.5mg Vitamin D 3 , 1g Vitamin E, 5mg Vitamin K 1 , mixed evenly to obtain fat-soluble vitamin solution b;

[0014] S03: Add the above-mentioned fat-soluble vitamin solution b to the solution a in step (1), stir and mix to obtain solution c

[0015] S04: Mix 10g vitamin C, 0.1g thiamine, 0.1g vitamin B 2 , 1.2g Niacinamide, 0.5g Pantothenic Acid, 0.1g Vitamin B 6 , 30mg biotin, 40mg folic acid, 0.3mg vitamin ...

Embodiment 2

[0022] The specific preparation method of the complex vitamin nanoliposome oral liquid provided by the embodiment of the present invention 2 is as follows:

[0023] S01: Weigh 5g of soybean lecithin, 1g of cholesterol, and 1g of Tween 80, add 30ml of absolute ethanol (or chloroform, methanol or methylene chloride, etc.), then put it into an eggplant-shaped bottle, and place it on a water bath evaporator (water bath temperature 50°C±1°C), stir until dissolved to obtain solution a;

[0024] S02: Put 5ml of olive oil into a container and add 1mg of vitamin A to it 1 , 0.1mg Vitamin D 3 , 50mg Vitamin E, 0.2mg Vitamin K 1 , mixed evenly to obtain fat-soluble vitamin solution b;

[0025] S03: adding the above-mentioned fat-soluble vitamin solution b to the solution a in step (1), stirring and mixing to obtain a solution c;

[0026] S04: Combine 10g vitamin C, 0.1g thiamine, 0.1g vitamin B 2 , 1.2g Niacinamide, 0.5g Pantothenic Acid, 1g Vitamin B 6 , 3g biotin, 4g folic acid, ...

Embodiment 3

[0033] The specific preparation method of the complex vitamin nanoliposome oral liquid provided by the embodiment of the present invention 3 is as follows:

[0034] S01: Weigh 5g of soybean lecithin, 1g of cholesterol, and 1g of Tween 80, add 30ml of absolute ethanol (or chloroform, methanol or methylene chloride, etc.), then put it into an eggplant-shaped bottle, and place it on a water bath evaporator (water bath temperature 55°C±1°C), stir until dissolved to obtain solution a;

[0035] S02: Put 5ml of olive oil into a container and add 40mg of vitamin A to it 1 , 1 mg Vitamin D 3 , 2g Vitamin E, 4mg Vitamin K 1 , mixed evenly to obtain fat-soluble vitamin solution b;

[0036] S03: adding the above-mentioned fat-soluble vitamin solution b to the solution a in step (1), stirring and mixing to obtain a solution c;

[0037] S04: Combine 30g vitamin C, 1g thiamine, 1g vitamin B 2 , 5g Niacinamide, 0.5g Pantothenic Acid, 0.1g Vitamin B 6 , 30mg biotin, 40mg folic acid, 0.3m...

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Abstract

The invention relates to an oral multi-vitamin nano liposome, belonging to the technical field of nutrient supplements. In multi-vitamin nano liposome oral liquid, nano liposome prepared from lecithin, cholesterol and tween-80 is used as an embedding agent, and the liposome contains vitamin A1, vitamin D3, vitamin E, vitamin K, vitamin C, vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid) and vitamin B12 (cyanocobalamin). The oral multi-vitamin nano liposome can be directly absorbed and utilized by small intestines, so that the absorption rate and the bioavailability of the oral multi-vitamin nano liposome are improved; and the oral multi-vitamin nano liposome can be widely applied to the industries of health-care food, functional beverage, cosmetics, medicine and the like, and is suitable for large-scale production.

Description

technical field [0001] The invention provides an oral compound vitamin nano liposome, which belongs to the technical field of nutrient supplements. Background technique [0002] Vitamins are a class of organic substances necessary to maintain human life activities, and are also important active substances to maintain human health. The content of vitamins in the body is very small, but they play an important role in the growth, metabolism and development of the human body. When they are deficient, they can lead to metabolic disorders and various diseases. When the body absorbs vitamins from the outside and cannot meet the needs of its life activities, it will cause metabolic dysfunction and cause various diseases. [0003] Due to the many types and different properties of vitamins, most of the vitamin preparations produced in China are single ingredients, and there are fewer multivitamin preparations, and the dosage forms are mostly tablets or capsules, and most of the liqui...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/303A61K31/714A61K9/127A61P3/02A61K31/355A61K31/375A61K31/51A61K31/525A61K31/593A61K31/05A61K31/455A61K31/4415A61K31/519A23L33/155
CPCA23V2002/00A61K31/714A23V2250/702A23V2250/704A23V2250/7044A23V2250/7046A23V2250/705A23V2250/7052A23V2250/7054A23V2250/7058A23V2250/706A23V2250/708A23V2250/714
Inventor 李明刚
Owner 李明刚
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