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Pulullan hollow capsule

A pullulan polysaccharide and hollow capsule technology is applied in the field of pullulan polysaccharide hollow capsules, which can solve the problems of low pullulan polysaccharide and uncontrollable disintegration time within a certain time, and achieve simple ingredients and controllable disintegration time. , the effect of high stability

Inactive Publication Date: 2014-12-31
ZHEJIANG YAOLIAN CAPSULES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the above-mentioned deficiencies in the prior art, and to provide a pullulan hollow capsule, which aims to solve the problem that the pullulan in the hollow capsule in the prior art is relatively low and the disintegration time limit cannot be controlled within a certain period of time. technical issues

Method used

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  • Pulullan hollow capsule
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A pullulan hollow capsule is prepared by the following preparation steps: first, 3.8 parts of glycerin, 67 parts of potassium chloride, 160 parts of carrageenan and 3.8 parts of deionized water are sequentially added to 1500 parts by mass of deionized water. Sodium dialkylsulfate and stir until uniformly dispersed; then add 38,500 parts by mass of deionized water at 80°C, and stir until the system is completely dissolved; then add 7617 parts of pullulan while stirring after the solution is clarified, and The glue is fully stirred, the stirring speed is 50r / min, the stirring time is 30min, and the glue is kept at 70°C for 4h, and at 55°C for 7h; finally, the glue is molded through a dipping mold, and the glue is molded at a temperature of 28°C. Dry at ℃ for 120 minutes to obtain a rubber base, and then demould, cut and fit the rubber base to obtain a hollow capsule.

[0027] After testing, the water content of the hollow capsule is 10wt%, the disintegration time limit of...

Embodiment 2

[0029] A pullulan hollow capsule is prepared by the following preparation steps: First, 3.9 parts of polyethylene glycol, 80 parts of potassium chloride, 67 parts of carrageenan and 3.9 parts of Parts of sodium lauryl sulfate and stirred separately until uniformly dispersed; then added 38500 parts by mass of deionized water at 90°C and stirred until the system was completely dissolved; then added 7904 parts of pullulan while stirring after the solution was clarified For polysaccharides, fully stir the glue solution with a stirring speed of 55r / min and a stirring time of 40min, and keep the glue solution at 70°C for 5 hours, and keep it at 50°C for 8 hours to defoam; Dry at a temperature of 27°C for 150 minutes to obtain a rubber base, and then demould, cut and fit the rubber base to obtain a hollow capsule.

[0030] After testing, the water content of the hollow capsule is 12wt%, the disintegration time limit of the hollow capsule is 4min, and the success rate is 99.0%.

Embodiment 3

[0032] A pullulan hollow capsule is prepared by the following preparation steps: First, 3.9 parts of glycerin, 53 parts of potassium chloride, 133 parts of carrageenan and 4.0 parts of deionized water are sequentially added to 1500 parts by mass of deionized water. Sodium dialkylsulfate and stir until uniformly dispersed; then add 38500 parts by mass of deionized water at 85°C, and stir until the system is completely dissolved; then add 7896 parts of pullulan while stirring after the solution is clarified, and The glue is fully stirred, the stirring speed is 60r / min, the stirring time is 25min, and the glue is kept at 75°C for 4h, and at 55°C for 6h; finally, the glue is molded through a dipping mold, and the glue is molded at a temperature of 29°C. Dry at ℃ for 160 minutes to obtain the rubber base, and then the rubber base is demoulded, cut and fitted to obtain a hollow capsule.

[0033] After testing, the water content of the hollow capsule is 11wt%, the disintegration time...

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Abstract

The invention is applicable to the technical field of a hollow capsule preparation, and discloses a pullulan hollow capsule comprising the following components by mass: 7617-8193 parts of pullulan, 3.8-4.1 parts of a moisturizing agent, 67-160 parts of a thickener, 53-87 parts of a coagulant aid and 3.8-4.1 parts of lauryl sodium sulfate, and the mass ratio range of pullulan to thickener is (0.008-0.02): 1. The pullulan hollow capsule is simple in composition and high in stability, pullulan content in the prepared hollow capsule is high, at the same time, a physical blending method for preparation of the pullulan hollow capsule can ensure that the time limit of hollow capsule disintegration is controllable, and the sources of the raw materials for the hollow capsule are non animal materials, so that potential risks of cumulative growth hormones or drugs left in animal bodies can be eliminated, and the overall performance and the market competitiveness of the hollow capsule can be improved.

Description

【Technical field】 [0001] The invention relates to a hollow capsule preparation, in particular to a pullulan hollow capsule. 【Background technique】 [0002] Hollow capsules are currently widely used in pharmaceutical, food and cosmetic industries, and are the main excipients for processing pharmaceutical capsule preparations. Most of the currently used hollow capsules are made of gelatin, and the hollow capsules made of gelatin usually have some defects, such as the mad cow disease and foot-and-mouth disease that have occurred in various parts of the world in recent years. The prepared gelatin raw material produces obvious insecurity, and the gelatin hollow capsule also has defects such as easy hardening, brittleness and difficult disintegration in addition. Moreover, due to the limited source of gelatin, it will react with some drugs and has poor compatibility, and gelatin may have antigenicity as a heterologous protein. In addition, because gelatin is produced with animal...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48
Inventor 陈永明甄晓贤
Owner ZHEJIANG YAOLIAN CAPSULES
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