Melatonin-containing double-layered osmotic pump controlled release tablet and preparation method thereof
An osmotic pump controlled release and melatonin technology, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and pharmaceutical formulas, can solve the problem of short biological half-life of melatonin, inability to stably release drugs, Drug release rate interference and other problems to achieve the effect of enhancing immunity, ensuring sleep time, and high utilization
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Embodiment 1
[0026] Such as figure 1 As shown, the osmotic pump controlled-release tablet containing melatonin described in the embodiment of the present invention is composed of an osmotic pump tablet and a moisture-proof protective film on its outer layer, wherein the osmotic pump tablet includes a double-layer tablet core and a coating half. Permeable membrane 1, the outer surface of the double-layer tablet core is wrapped with a semipermeable membrane 1 and a drug release hole 2 is added on the semipermeable membrane 1, the upper layer of the double-layer tablet core is a melatonin-containing drug layer 3, The lower layer is the push layer 4 containing osmotic pressure active substances. When the controlled-release tablet enters the gastric juice, the moisture-proof protective film on the outer layer disintegrates rapidly, and the melatonin in the protective film is completely released, providing the human body with the first burst dose. Then, The water molecules in the digestive tract...
Embodiment 2
[0036] Such as figure 1 As shown, the osmotic pump controlled-release tablet containing melatonin described in the embodiments of the present invention, the controlled-release tablet formula is as follows:
[0037] ①Based on the total dosage per 1000 tablets, the melatonin-containing drug layer 3 is composed of the following materials:
[0038] Melatonin 3g, sodium chloride 60g, mannitol 30g, lactose 30g, dextrin 10g, polyethylene oxide (molecular weight 300,000, PEO) 1.0g, polyvinylpyrrolidone (PVP K29 / 32) 6g, stearic acid Magnesium 1.4g and appropriate amount of ethanol;
[0039] ②Based on the total dosage per 1000 tablets, the push layer 4 containing osmotic pressure active substances is composed of the following materials:
[0040] Sodium chloride 40g, lactose 15g, polyethylene oxide (molecular weight 5 million, PEO) 40g, polyvinylpyrrolidone (PVP K29 / 32) 9.5g, iron oxide red 1g, magnesium stearate 1g and ethanol amount;
[0041] ③Based on the total dosage per 1000 piec...
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