Four-ingredient herba andrographitis powder solid dispersion and preparation method thereof

A technology of solid dispersion and Xinlian powder, which is applied in the field of Siwei Chuanxinlian powder solid dispersion and its preparation, to achieve the effects of improving bioavailability, facilitating adjustment, and increasing solubility

Active Publication Date: 2014-12-03
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This Siwei Chuanxinlian Powder is insoluble in water and needs to be eaten with ingredients. This method is time-consuming and laborious, and due to the poor solubility of its active ingredients, poor absorption and availability, and slow onset of action, the bioavailability of the Siwei Chuanxinlian Powder is low.

Method used

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  • Four-ingredient herba andrographitis powder solid dispersion and preparation method thereof
  • Four-ingredient herba andrographitis powder solid dispersion and preparation method thereof
  • Four-ingredient herba andrographitis powder solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A kind of Siwei Chuanxinlian powder solid dispersion, used raw material and weight percent are:

[0034] Andrographis 27%

[0035] Polygonum 9%

[0036] Folium 12%

[0037] Gourd Tea 12%

[0038] Polyethylene glycol 6000 22%

[0039] Poloxamer 188 12%

[0040] Glycerin 6%

[0041] The preparation method of above-mentioned Siwei Chuanxinlian powder solid dispersion, comprises the following steps:

[0042] (1) Take each raw material in proportion, and use the superfine pulverization method to pulverize Andrographis paniculata, Folium Folium L., Polygonum punctatus, and gourd tea through a 100-mesh sieve, and mix to obtain superfine powder;

[0043] (2) Soak the superfine powder with 95% (v / v) ethanol for 30 minutes to obtain the intermediate product a, the amount of 95% ethanol is twice the quality of the superfine powder;

[0044] (3) Dissolving Poloxamer 188 in 95% (v / v) ethanol and mixing it with intermediate product a to obtain intermediate product b, the amoun...

Embodiment 2

[0048] Siwei Chuanxinlian powder solid dispersion, its raw material and percentage by weight are:

[0049] Andrographis 27%

[0050] Polygonum 9%

[0051] Folium 12%

[0052] Gourd Tea 12%

[0053] Polyethylene glycol 6000 28%

[0054] Poloxamer 188 6%

[0055] Propylene Glycol 6%

[0056] The preparation method of above-mentioned Siwei Chuanxinlian powder solid dispersion, comprises the following steps:

[0057] (1) Take each raw material in proportion, and use the superfine pulverization method to pulverize Andrographis paniculata, Folium Folium L., Polygonum punctatus, and gourd tea through a 100-mesh sieve, and mix to obtain superfine powder;

[0058] (2) Soak the superfine powder with 95% ethanol for 40 minutes to obtain the intermediate product a, the amount of 95% ethanol is twice the quality of the superfine powder;

[0059] (3) Poloxamer 188 was dissolved in 95% ethanol and then mixed with intermediate product a to obtain intermediate product b. The amount of e...

Embodiment 3

[0063] Siwei Chuanxinlian powder solid dispersion, its raw material and percentage by weight are:

[0064] Andrographis 27%

[0065] Polygonum 9%

[0066] Folium 12%

[0067] Gourd Tea 12%

[0068] Polyethylene glycol 6000 25%

[0069] Poloxamer 188 6%

[0070] Glycerin 9%

[0071] The preparation method of above-mentioned Siwei Chuanxinlian powder solid dispersion, comprises the following steps:

[0072] (1) Take each raw material in proportion, and use the superfine pulverization method to pulverize Andrographis paniculata, Folium Folium L., Polygonum punctatus, and gourd tea through a 100-mesh sieve, and mix to obtain superfine powder;

[0073] (2) Soak the superfine powder with 95% ethanol for 35 minutes to obtain the intermediate product a, the amount of 95% ethanol is twice the quality of the superfine powder;

[0074](3) Poloxamer 188 was dissolved in 95% ethanol and then mixed with intermediate product a to obtain intermediate product b. The amount of ethanol us...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a four-ingredient herba andrographitis powder solid dispersion. The four-ingredient herba andrographitis powder solid dispersion comprises the following ingredients: herba andrographitis, folium isatidis, red-knees herb, desmodium triquetrum, polyethylene glycol 6000, poloxamer and glycerol or propylene glycol. The four-ingredient herba andrographitis powder solid dispersion is prepared by adopting a superfine grinding technology and a solid dispersion technology, a proper carrier is selected, leaching of effective ingredients of the four-ingredient herba andrographitis powder solid dispersion is facilitated, and the dispersity and specific surface area of the medicines are increased, so that the solubility and dissolution rate of the four-ingredient herba andrographitis powder solid dispersion are increased, the drug bioavailability is improved, and regulation, administration and development of curative effects are facilitated. The four-ingredient herba andrographitis powder solid dispersion disclosed by the invention has the efficacies of clearing away heat and toxic materials, and dehumidifying and relieving dyspepsia, and is mainly used for treating the diseases such as diarrhea and indigestion of pigs.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a solid dispersion of Siwei Chuanxinlian powder and a preparation method thereof. Background technique [0002] Due to the deteriorating environment and the rapid development of the aquaculture industry, various diseases are coming one after another. Therefore, the extensive use of antibiotics, chemical synthetic drugs and hormone drugs in feed has brought great harm to aquaculture production, affecting food safety and people's health. Chinese herbal medicine is relatively safe, effective, cheap and easy to get, and has dual functions of nutrition, health care and disease treatment. But Chinese herbal medicine also has many defects, such as insoluble in water, poor absorption and utilization, slow onset of action, etc. In recent years, the technology of applying some new formulations to Chinese herbal medicine has been widely valued. Solid di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K36/704A61K9/00
Inventor 张遂平唐洪峰郭芳茹杨慧敏吴胜耀杜雪峰郭菊王菊萍闫树森牛咏梅张海涛
Owner 河南亚卫动物药业有限公司
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