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Gelsmium elegans alkaloid monomer application method

The technology of a gynecine alkaloid and its application method is applied in the field of application of a gynecine alkaloid monomer in the preparation of veterinary medicine, animal health products and health feed, and achieves the effects of small side effects and good application prospects

Inactive Publication Date: 2014-11-19
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of kelezin and kelezin A in the preparation of veterinary medicine, animal health products and health feed is rarely reported.

Method used

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  • Gelsmium elegans alkaloid monomer application method
  • Gelsmium elegans alkaloid monomer application method
  • Gelsmium elegans alkaloid monomer application method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The porcine AHR plasmid and the luciferase reporter gene plasmid were co-transfected into HepG2 cells to construct a porcine AHR activation detection system. The successfully transfected cells were cultured and divided into 4 groups, with 3 parallel samples in each group, respectively added DMSO, 10nM dioxin (AHR activator), 10nM kelsin, and 10nM kelsin A for 24 hours. After adding the fluorescein substrate for reaction, the fluorescence intensity was measured with a fluorescence detector. From figure 1 It can be seen that compared with DMSO, dioxin, kinesin, and kinesin A can significantly activate the AHR receptor, but the activating effect of kinesin and kelesin A on the pig AHR receptor is lower than that of DMSO. Evils. In their research, Jensen et al. found that by activating AHR, and then reverse-regulating the inflammatory pathway mediated by NFkB, the effect of effectively inhibiting the inflammatory response can be achieved (Brenda A Jensen, Rebecca J Leeman...

Embodiment 2

[0032] Research on the prevention and treatment effect of kelezin and kelezin A in kelezin alkaloid monomers: male Kunming mice were selected and randomly divided into 4 groups, namely the control group, kelezin group, kelezin A group and ind Domethacin group (anti-inflammatory positive group), 10 mice in each group. Intragastric administration, the control group was intragastrically administered an equal volume of normal saline, once a day, for 3 days, and 45 minutes after the last administration, 0.05ml of xylene was applied to the right ear of the mouse. After 25 minutes, they were killed by neck dislocation, and both ears were cut off, punched with a puncher with a diameter of 8 mm, and weighed on an electronic balance. Subcutaneously inject 0.1ml of 10% egg white solution into the right hind foot of the mouse. After 30 minutes, use a capillary tube to amplify the volume of the left and right foot, and use the difference between the volume of the two feet as the degree of ...

Embodiment 3

[0034] In a large-scale pig farm, three batches of weaned piglets were selected, and each batch was divided into three groups. Kissine A was fed continuously for 15 days, and the morbidity and mortality of yellow and white scour of piglets were counted. Figure 5 , 6 It can be seen that kelezin and kelezin A can significantly reduce the incidence and mortality of yellow and white scour of weaned piglets.

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Abstract

The invention discloses a gelsmium elegans alkaloid monomer application method, belongs to the technical field of veterinary drugs, animal health care products and animal health care fodders and particularly relates to application of a gelsmium elegans alkaloid monomer in preparing veterinary drugs, animal health care products and animal health care fodders. The gelsmium elegans alkaloid monomer can reduce the morbidity of weaned piglet's yellow-white dysentery, has a significant impact on the development of veterinary drugs, animal health care products and animal health care fodders, and opens up a new field for the comprehensive utilization of gelsmium elegans.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, animal health care product and health feed, and in particular relates to the application of kelp alkaloid monomer in the preparation of veterinary medicine, animal health product and health feed. Background technique [0002] Glycyrrhizae is the whole herb of the Strychnaceae plant, also known as the heartbroken grass, kudzu, poisonous root, big tea medicine, etc. It is bitter, slightly pungent, hot in nature, and highly poisonous. It is mainly distributed in Zhejiang, Fujian, Guangdong, Guangxi, Hunan, Guizhou, Yunnan and other places. Our country has a very long history of using gou kiss. "Shen Nong's Materia Medica" records that gou kiss "mainly treats gold sores, breast pain, apoplexy, cough and upper qi, and ghosts." Because of its high toxicity, it has been used externally by folks to reduce swelling. Toxin extraction, killing insects and relieving itching; Gelkins is very toxi...

Claims

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Application Information

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IPC IPC(8): A61K31/439A23L1/29A61P31/04A61P1/12A23L33/00
Inventor 孙志良邬静
Owner HUNAN AGRICULTURAL UNIV
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