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Use of albicans albicans in the preparation of hypoxia-resistant medicine

A technology of R. albicans and hypoxia resistance, applied in the field of medicine, can solve the problems of different types of R. albicans, and achieve the effects of less toxic and side effects, easy cultivation, and low cost

Active Publication Date: 2017-10-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of the same species of P. albicans is completely different due to the different growth environment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of the extract of Racula albicans

[0015] The fermented liquid was obtained by fermenting the fungus albicans, centrifuged at 4000 rpm for 10 minutes, the supernatant was discarded, and the precipitate was freeze-dried to obtain the fungus powder, which was then extracted with deionized water for 2 The second time, according to the liquid-to-material ratio of 1:40, the temperature is 90 ° C, the first time is 3 hours, the second time is 1 hour, the two water extracts are combined, and the filtrate is obtained with a 200 mesh filter cloth, and the filtrate is concentrated. Add ethanol until the alcohol concentration is 80%, stir overnight, filter and take the precipitate, and freeze-dry the precipitate to obtain the extract of R. albicans.

Embodiment 2

[0017] The fermented liquid was obtained by fermenting the fungus albicans, centrifuged at 4500 rpm for 8 minutes, the supernatant was discarded, and the precipitate was freeze-dried to obtain the fungus powder of the fungus. The material ratio is 1:40, the temperature is 80°C, the first time is 3 hours, the second time is 1 hour, the two water extracts are combined, and the filtrate is obtained with a 200-mesh filter cloth, the filtrate is concentrated, and then ethanol is added to ethanol. The concentration is 80%, stir overnight, filter and take the precipitate, and freeze-dry the precipitate to obtain the extract of R. albicans.

Embodiment 3

[0019] Get the fermented liquid from the fungus A. albicans through a fermenter, centrifuge it at 5000 rpm for 5 minutes, discard the supernatant, and freeze-dry the precipitate to obtain the powder of the fungus, then extract the powder twice with water, press the liquid The material ratio is 1:40, the temperature is 70°C, the first time is 3 hours, the second time is 1 hour, the two water extracts are combined, and the filtrate is obtained with a 200-mesh filter cloth, the filtrate is concentrated, and then ethanol is added to ethanol. The concentration is 80%, stir overnight, filter and take the precipitate, and freeze-dry the precipitate to obtain the extract of R. albicans.

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PUM

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Abstract

The present invention provides the use of A. albicans in the preparation of hypoxia-resistant health care products. The extract of A. albicans is prepared by fermentation, water extraction, alcohol precipitation and freeze-drying. Animal experiments have proved to have significant Resistant to hypoxia. The preparation method of the invention is simple, the cost is low, the toxic and side effects are small, the hypoxia-resistant effect is remarkable, and it is suitable for the preparation of hypoxia-resistant health food or pharmaceutical preparation.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the use of R. albicans in the preparation of hypoxia-resistant medicines. Background technique [0002] Oxygen is necessary for the existence of most life forms. After people living in the plains enter the plateau, the lack of oxygen has a great impact on human body functions, resulting in a decline in labor capacity. The higher the altitude, the more obvious the decline in labor capacity. [0003] Hypoxia widely exists in human life and work. It involves medicine, sports, military and other fields. It is also the pathological basis for the occurrence and development of many diseases. The brain and heart muscle are very sensitive to hypoxia. Generally, short-term or mild hypoxia can cause rapid heartbeat, purple lips, dizziness, headache, and may even cause symptoms such as vomiting, diarrhea, shortness of breath, and coma; prolonged or severe hypoxia can cause insufficient en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/07A61P39/00A23L31/00A23L2/52
Inventor 王迪李臣亮滕利荣孟庆繁宋佳逯家辉刘艳王贞佐周毓麟刘春刚程瑛琨权宇彤
Owner JILIN UNIV
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