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Application of two compositions in preparation of drug for combinedly treating diabetic nephropathy

A technology for combined treatment of diabetic nephropathy, applied in drug combinations, urinary system diseases, active ingredients of hydroxyl compounds, etc., can solve problems such as complex pathogenesis of DN

Inactive Publication Date: 2014-11-05
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pathogenesis of DN is very complicated. Such single-target drugs can only delay the progression of DN, but cannot completely block its development to end-stage renal disease, and can easily lead to hypotension, hyperkalemia, angioedema and allergic reactions. Toxic side effects such as dermatitis

Method used

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  • Application of two compositions in preparation of drug for combinedly treating diabetic nephropathy
  • Application of two compositions in preparation of drug for combinedly treating diabetic nephropathy
  • Application of two compositions in preparation of drug for combinedly treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] a) The raw material drug formula is:

[0198] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense 13.2g Paeoniae Rubra 33g Dalbergia 13.2g Sandalwood 13.2g Scorpion 19.8g Cicada slough 46.2g Centipede 6.6g Borneol 33g Fried Suanzaoren 33g;

[0199] b) Crushing process of medicinal materials:

[0200] The scorpion, leech, centipede, ground beetle and cicada slough five kinds of insect medicines, which are cleaned, washed and processed, are formulated according to the prescription and crushed by a pulverizer. The fineness of the powder reaches more than 80 mesh; The powdered medicinal powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicinal powder is less than 30 μm;

[0201] c) Extraction concentration and drying process:

[0202] Add water to extract the volatile oil of Jiangxiang and sandalwood, and then extract with water. Add appropriate amount of water to decoct the red peony root and f...

Embodiment 2

[0207] a) The raw material drug formula is:

[0208] Ginseng 66g Leech 52.8g Wood Beetle 46.2g Frankincense 13.2g

[0209] Radix Paeoniae Alba 33g Dalbergia 13.2g Sandalwood 13.2g Scorpio 59.4g

[0210] Cicada slough 46.2g centipede 6.6g borneol 33g fried jujube kernel 33g

[0211] b) Crushing process of medicinal materials:

[0212] The scorpion, leech, centipede, ground beetle and cicada slough five kinds of insect medicines, which are cleaned, washed and processed, are formulated according to the prescription and crushed by a pulverizer. The fineness of the powder reaches more than 80 mesh; The powdered medicinal powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicinal powder is less than 70 μm;

[0213] c) Extraction concentration and drying process:

[0214] Add water to extract the volatile oil of Jiangxiang and sandalwood, and then extract with water. Add appropriate amount of water to decoct ...

Embodiment 3

[0218] Embodiment 3: the preparation of pill

[0219] a) The raw material drug formula is:

[0220] Ginseng 39.6g Leech 66g Wood Beetle 46.2g Frankincense 13.2g

[0221] Radix Paeoniae Alba 33g Dalbergia 13.2g Sandalwood 13.2g Scorpio 46.2g

[0222] Cicada slough 46.2g centipede 6.6g borneol 33g fried jujube kernel 33g

[0223] b) Crushing process of medicinal materials:

[0224] The scorpion, leech, centipede, ground beetle and cicada slough five kinds of insect medicines, which are cleaned, washed and processed, are formulated according to the prescription and crushed by a pulverizer. The fineness of the powder reaches more than 80 mesh; The powdered medicinal powder is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicinal powder is 10 μm;

[0225] c) Extraction concentration and drying process:

[0226] Add water to extract the volatile oil of Jiangxiang and sandalwood, and then extract with water. Add ...

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Abstract

The invention discloses an application of two compositions in preparation of a drug for combinedly treating diabetic nephropathy. The two compositions are respectively a composition A and a composition B, wherein the composition A is composed of followi ng raw material medicines: ginseng, hirudos, ground beeltles, prepared frankincense, red peony roots, dalbergia odorifera, sanders, scorpions, cicada slough, centipedes, borneol and fried spina date seeds; and the composition B is composed of following raw material medicines: ginseng, polygonatum kingianum, rhizoma atractylodis, sophora flavescens, poria cocos, radix ophiopogonis, mix-fried polygonum multiflorum, radix rehmanniae, cornus officinalis, coptidis rhizome, fortune eupatorium herb, litchi seeds, epimedium, rhizoma anemarrhenae, salviae miltiorrhizae, lobed kudzuvine roots and cortex lycii radicis. The invention discloses an application of the composition A and the composition B in preparation of the drug used for combinedly inhibiting Akt / mTOR signal transduction pathway activation. By means of the combination of the composition A and the composition B, a treatment effect of the diabetic nephropathy is good without any obvious side effect.

Description

technical field [0001] The invention belongs to the field of medicine application, in particular to the combined application of two traditional Chinese medicine compositions in the treatment of diabetic nephropathy. Background technique [0002] Diabetic nephropathy (DN), as one of the most common chronic microvascular complications of diabetes, seriously affects the quality of life of diabetic patients. The pathogenesis of DN is very complex and has not been fully elucidated so far. Genetic factors, glucose and lipid metabolism disorders, renin-angiotensin system (RAS) disorders, changes in glomerular hemorheology and hemodynamics, inflammatory infiltration, and various growth factors and cell Abnormal expression of factors are involved in the occurrence and development of DN. Among many pathogenic factors, vascular endothelial growth factor (VEGF) plays an important role in DN lesions. It can stimulate endothelial cell proliferation and differentiation, inhibit endotheli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K36/8969A61P3/10A61P13/12A61K35/64A61K35/62A61K31/045
Inventor 吴以岭魏聪丁英钧
Owner HEBEI YILING MEDICINE INST
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