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Antibacterial polyelectrolyte composite nanofiber membrane and preparation method thereof

A technology of composite nanofibers and nanofiber membranes, which is applied in the field of biomedical materials and medical devices, can solve the problems such as the lack of antibacterial properties of nanobacterial cellulose membranes, the unsatisfactory effect of wound healing, and the inability to inhibit wound infection, and achieve good results. The effects of biodegradability, simple and easy preparation, and mild conditions

Inactive Publication Date: 2014-10-08
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the ordinary nano-bacterial cellulose membrane itself has no antibacterial properties, cannot inhibit wound infection, and its ability to stop bleeding is not enough, and the effect of promoting wound healing is not ideal.

Method used

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  • Antibacterial polyelectrolyte composite nanofiber membrane and preparation method thereof

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preparation example Construction

[0027] The preparation method of described antibacterial polyelectrolyte composite nanofiber membrane comprises the steps:

[0028] (1) The commercially available bacterial cellulose nanofiber membrane is oxidized and modified by using sodium bromide, sodium hypochlorite, and tetramethylpiperidine to obtain a negatively charged bacterial cellulose nanofiber membrane, and freeze-dried; for specific methods, refer to CN101182561A nano-bacteria fiber The method of aldolization modification is described in the detailed description.

[0029] (2) Immerse the negatively charged basement membrane prepared in step (1) in a chitosan cationic polymer solution with a concentration of 0.1 to 50 g / L, take it out after 1 to 10 minutes, and wash it with deionized water Net surface residual polycation solution;

[0030] (3) Then immerse the membrane in a polyanion solution with a concentration of 0.1 to 50 g / L, take it out after 1 to 10 minutes, wash the residual polyanion solution on the sur...

Embodiment 1

[0037] Bacterial cellulose film (specification model 25*35cm; thickness 3-4mm; supplier Hainan Yide Food Co., Ltd.) was obtained by fermentation of Acetobacter xylinum. In an aqueous solution of sodium, 12wt% sodium hypochlorite, and 1wt% tetramethylpiperidine, stir constantly, react at 0-4° C. for 4 hours, and adjust the pH to 10 with sodium hydroxide. After the reaction was completed, the oxidized bacterial cellulose membrane was fully washed with deionized water and freeze-dried. Immerse the oxidized bacterial cellulose membrane in the quaternized N-aryl chitosan with a concentration of 10g / L, take it out after 10 minutes, wash the residual polycation solution on the surface with deionized water, and freeze-dry to obtain Bacterial cellulose nanofiber membranes containing quaternized N-aryl chitosan.

Embodiment 2

[0039] Bacterial cellulose film (specification model 25*35cm; thickness 3-4mm; supplier Hainan Yide Food Co., Ltd.) was obtained by fermentation of Acetobacter xylinum. In an aqueous solution of sodium, 10wt% sodium hypochlorite, and 1wt% tetramethylpiperidine, stir constantly, react at 0-4° C. for 6 hours, and adjust the pH to 11 with sodium hydroxide. After the reaction was completed, the oxidized bacterial cellulose membrane was fully washed with deionized water and freeze-dried. Immerse the oxidized bacterial cellulose membrane in the chitosan cationic solution containing hydroxypropyl trimethyl quaternary ammonium salt with a concentration of 1g / L, take it out after 2 minutes, wash the residual polycation solution on the surface with deionized water, and continue Soak the membrane in a sodium hyaluronate polyanion solution with a concentration of 1 g / L, take it out after 2 minutes, wash the residual polyanion solution on the surface with deionized water, and repeat the so...

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Abstract

The invention provides an antibacterial polyelectrolyte composite nano-fiber membrane and a preparation method thereof. The antibacterial polyelectrolyte composite nano-fiber membrane with an antibacterial performance is prepared from chitosan cationic polymers by using an oxidized bacterial cellulose nano-fiber membrane as a base membrane and utilizing the electrostatic effect between anionic and cationic polyelectrolytes. The antibacterial polyelectrolyte composite nano-fiber membrane has excellent hydrophilia and charge performance, utilizes the electrostatic interaction between the anionic and cationic polyelectrolytes and is compounded with the chitosan cationic polymers by adopting a layer-layer adsorption method, and a multi-layer composite nano-fiber membrane is formed by selecting repeated adsorption and alternate deposition. The antibacterial polyelectrolyte composite nano-fiber membrane protects the unique nano-fiber structure of bacterial cellulose membranes, is controllable in antibacterial layer thickness nanometer grade, and is an ideal medical wound dressing with good antibacterial performance, excellent air permeability and strong water holding capacity.

Description

Technical field: [0001] The invention relates to related fields such as biomedical materials and medical devices, in particular to an antibacterial polyelectrolyte composite nanofiber membrane and a preparation method thereof. Background technique: [0002] Nano-bacterial cellulose (BC) is a natural biopolymer synthesized by microbial fermentation, which has biological activity, biodegradability, bioadaptability, high crystallinity, high water holding capacity, and ultrafine nanofibers. Network, high tensile strength and elastic modulus and many other unique physical, chemical and mechanical properties, and nano bacterial cellulose is synthesized by microbial fermentation, its performance and shape can be adjusted, the production process is green and environmentally friendly, with low cost and high yield. Therefore, it has broad application prospects in medical fields such as wound dressings, artificial skin, drug sustained-release carriers, and tissue engineering scaffold m...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61L27/20A61L27/54A61L27/60A61K47/38
Inventor 王怡红姚琛李玉松钱坤
Owner SOUTHEAST UNIV
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