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Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof

A nano drug carrier and magnetocaloric effect technology, applied in the field of medicine, can solve the problems of reducing drug efficacy, poor selectivity of chemotherapy drugs, killing normal cells, etc., achieve good delivery efficiency, increase storage capacity, and reduce complications

Inactive Publication Date: 2014-10-08
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug chemotherapy is a common method in cancer treatment, but many chemotherapy drugs have poor selectivity and are difficult to specifically reach cancer cells, which will not only reduce the efficacy of drugs, but also have a greater killing effect on many normal cells

Method used

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  • Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof
  • Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof
  • Nano-medicinal carrier with magnetocaloric effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The nano-drug carrier provided in this example includes mesoporous silica particles and Fe embedded in the mesoporous silica particles. 3 o 4nanoparticles. The nano drug carrier preparation method comprises the following steps:

[0036] Step 1: Take FeCl 3 ·6H 2 O and FeCl 2 4H 2 O each 19.2 mmoles, after being dissolved in 25 milliliters of deionized water, add 0.85 milliliters of concentrated hydrochloric acid (36-38%); Then 250 milliliters of 1.5 mol / liter sodium hydroxide solution is added dropwise in the above solution, and Stirring at room temperature at a stirring speed of 700 rpm for 1 hour produced a black precipitate.

[0037] Step 2: Use a magnet block to collect the black precipitate, wash the black precipitate three times with deionized water, then wash three times with ethanol, and finally dry it in vacuum at 60°C for 24 hours to obtain Fe 3 o 4 nanoparticles.

[0038] Step 3: Take 0.4 grams of Fe 3 o 4 Nanoparticles were ultrasonically disperse...

Embodiment 2

[0045] The nano-drug carrier provided in this example is an amino-modified nano-drug carrier, and the silane coupling agent used is γ-aminopropyltriethoxysilane, and its preparation method is as follows:

[0046] Take 1 gram of the nano drug carrier prepared in Example 1, ultrasonically disperse it in absolute ethanol to obtain a suspension, then quickly add 3 ml of γ-aminopropyltriethoxysilane to the above suspension, seal the container and stir at room temperature for 24 hours, and finally wash off the unreacted γ-aminopropyltriethoxysilane with absolute ethanol and vacuum-dry to obtain the amino-modified nano-drug carrier.

[0047] The particle diameter of the amino-modified nano drug carrier is about 150 nanometers, and the average mesoporous diameter of the mesoporous silicon oxide particles is 3.2 nanometers.

[0048] In addition, the silane coupling agent used in this example is γ-aminopropyltrimethoxysilane, and the outer surface of the mesoporous silica particles invo...

Embodiment 3

[0050] The nano-drug carrier provided in this example is a nano-drug carrier modified by RBITC, which is used to observe the uptake of the nano-drug carrier by cells under a fluorescence microscope. The silane coupling agent that adopts is RBITC-APTES silane coupling agent, and its preparation method is:

[0051] Take 15 mg of Rhodamine B isothiocyanate (Rhodamine B isothiocyanate, RBITC) and 100 microliters of γ-aminopropyltriethoxysilane, add 5 milliliters of absolute ethanol, and stir in a sealed container under dark room conditions for 24 Hours, the rhodamine B modified silane coupling agent (RBITC-APTES) was obtained.

[0052] Then, take 20 mg of the nano-drug carrier prepared in Example 1, disperse it in 6 ml of absolute ethanol, add 1 ml of RBITC-APTES silane coupling agent, and stir in a sealed container for 24 hours in a dark room. Finally, the above particle solution was centrifuged, washed with absolute ethanol for several times to remove the unreacted RBITC-APTES ...

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Abstract

The invention provides a nano-medicinal carrier with magnetocaloric effect. The nano-medicinal carrier with grain diameter of 50-200 nanometers comprises mesoporous silica particles and Fe3O4 nano-particles embedded inside the mesoporous silica particles, wherein the mesoporous diameter of the mesoporous silica particles is 2-10 nanometers, and the mesoporous channel is in a radial shape from the inner core to outside; the diameter of the Fe3O4 particles is 15-20 nanometers. The invention further provides a preparation method of the nano-medicinal carrier and application of the nano-medicinal carrier in loading anti-cancer medicaments. The nano-medicinal carrier is high in drug storage capacity, and can be used for remarkably improving the anti-cancer drug high-performance transmission efficiency, remarkably improving the curative effect of tumor treatment, and realizing cancer therapy by virtue of medical chemotherapy and magnetocaloric therapy.

Description

technical field [0001] The invention relates to a nano-medicine carrier with magnetocaloric effect, a preparation method of the nano-medicine carrier and an application of the nano-medicine carrier, belonging to the technical field of medicine. Background technique [0002] At present, the incidence of cancer in the world shows a sharp upward trend, and the main methods of clinical treatment of cancer at home and abroad are surgery, radiotherapy, hyperthermia and drug chemotherapy. Drug chemotherapy is a common method in cancer treatment, but many chemotherapy drugs have poor selectivity and are difficult to specifically reach cancer cells, which not only reduces the efficacy of drugs, but also has a greater killing effect on many normal cells. [0003] In order to improve the therapeutic effect of cancer, combination therapy is generally used at present, and different cancer treatment methods are applied to the same tumor site at the same time, and the combination of drug c...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/04B82Y5/00A61K45/00A61P35/00
Inventor 朱钰方陶翠莲
Owner UNIV OF SHANGHAI FOR SCI & TECH
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