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A kind of production improvement method of Nocardia rubrum skeleton emulsion

A technology of Nocardia rubrum and emulsion, which is applied in the field of production improvement of Nocardia rubrum skeleton emulsion, can solve the problems of poor emulsification effect stability, difficult to achieve sterilization and filtration, and impurities containing titanium powder, etc., and achieve improvement Sterilization and filtration effect, improvement of efficiency and processing scale, effect of reducing particle size

Active Publication Date: 2016-10-26
FUJIAN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the product obtained by the current production process contains titanium powder impurities, the stability of the emulsification effect is poor, and it is difficult to achieve sterilization and filtration.

Method used

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  • A kind of production improvement method of Nocardia rubrum skeleton emulsion
  • A kind of production improvement method of Nocardia rubrum skeleton emulsion
  • A kind of production improvement method of Nocardia rubrum skeleton emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. The original powder of the cell wall skeleton of Nocardia rubrum and auxiliary materials are accurately weighed and prepared according to the prescription amount (the prescription is the same as that of Comparative Example 1).

[0050] 2. Deepen the dispersing head of the high-speed shearing machine into the liquid medicine to about 1-2cm to the bottom, and turn on the power for shearing and dispersing. Adjust the rotating speed to 17000rpm, and cut for 20min.

[0051] 3. After shearing, transfer the medicinal solution to the sampling cup of the high-pressure homogenizer, and turn on the high-pressure homogenizer for homogenization. The working pressure is 1500bar.

[0052] 4. Collect the homogenized drug solution and perform the second homogenization.

[0053] 5. After the drug solution is homogenized twice, a uniform emulsion is obtained. Transfer the emulsion to a filtration system for filtration. The pore size of the filter element is 0.22 μm.

Embodiment 2

[0055] 1. The original powder of the cell wall skeleton of Nocardia rubrum and auxiliary materials are accurately weighed and prepared according to the prescription amount (the prescription is the same as that of Comparative Example 1).

[0056] 2. Deepen the dispersing head of the high-speed shearing machine into the liquid medicine to about 1-2cm to the bottom, and turn on the power for shearing and dispersing. Adjust the rotating speed to 17000rpm, and cut for 20min.

[0057] 3. After shearing, transfer the medicinal solution to the sampling cup of the high-pressure homogenizer, and turn on the high-pressure homogenizer for homogenization. The working pressure is 1500bar.

[0058] 4. Collect the homogenized drug solution and perform the second homogenization.

[0059] 5. After the drug solution is homogenized twice, a uniform emulsion is obtained. Transfer the emulsion to a filtration system for filtration. The pore size of the filter element used in the first filtration...

Embodiment 3

[0061] 1. The original powder of the cell wall skeleton of Nocardia rubrum and auxiliary materials are accurately weighed and prepared according to the prescription amount (the prescription is the same as that of Comparative Example 1).

[0062] 2. Deepen the dispersing head of the high-speed shearing machine into the liquid medicine to about 1-2cm to the bottom, and turn on the power for shearing and dispersing. Adjust the rotating speed to 15000rpm, and cut for 20min.

[0063] 3. After shearing, transfer the medicinal solution to the sampling cup of the high-pressure homogenizer, and turn on the high-pressure homogenizer for homogenization. The working pressure is 1500bar.

[0064] 4. Collect the homogenized drug solution and perform the second homogenization.

[0065] 5. After the drug solution is homogenized twice, a uniform emulsion is obtained. Transfer the emulsion to a filtration system for filtration. The pore size of the filter element used in the first filtration i...

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Abstract

The invention discloses a method for improving production of nocardia rubra frame emulsion. The method comprises the following steps: (1) preparing raw materials according to the prescription; (2) pre-treating a liquid medicine by utilizing a high-speed shearing machine at a shearing speed of 10000-20000rpm (Revolutions Per Minute) for 10-30 minutes; (3) homogenizing by utilizing a high-pressure homogenizer at a pressure of 1000-2000bar for 2-4 times; (4) performing three-stage filtration on the emulsion, wherein the first-stage granularity is 0.8-1.0 mu m, the second-stage granularity is 0.45-0.65 mu m, and the third-stage granularity is 0.22 mu m. The nocardia rubra frame emulsion does not contain titanium powder impurities, has a stable emulsification effect, and can conveniently realize sterilization and filtration.

Description

technical field [0001] The invention relates to a method for preparing and filtering Nocardia rubrum cell wall skeleton emulsion in the technical field of microorganisms, in particular to a method for sterilizing and filtering Nocardia rubrum cell wall skeleton raw powder after emulsification. Background technique [0002] Nocardia rubra (Nocardia rubra) is a microorganism with strong immune activity. It obtains its cell wall skeleton through cell crushing, removal of cell contents, cell membrane proteins and lipids and other components. The cell wall skeleton of Nocardia rubrum is an active substance containing nocardia mycolic acid, neutral polysaccharides and mucopeptides, which can non-specifically stimulate cellular immune function, promote the secretion of various cytokines, and participate in the process of anti-tumor immunity , for the treatment or adjuvant therapy of various tumors. [0003] In the prior art, the production method of Nocardia rubrum cell wall skele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K35/74A61P35/00A61P37/04
Inventor 徐镜蔡金柱查贝贝谢必峰王曦邵恩文
Owner FUJIAN SHANHE PHARMA
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