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Injectable drug-loaded xanthan gum/methyl cellulose composite solution and preparation method thereof

A technology of methyl cellulose and composite solution, applied in the field of medicine, can solve the problem of no injectable drug-loaded hydrogel and achieve good mechanical properties

Active Publication Date: 2014-10-08
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we have not found reports on the preparation of injectable drug-loaded hydrogels using xanthan gum and methylcellulose

Method used

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  • Injectable drug-loaded xanthan gum/methyl cellulose composite solution and preparation method thereof
  • Injectable drug-loaded xanthan gum/methyl cellulose composite solution and preparation method thereof
  • Injectable drug-loaded xanthan gum/methyl cellulose composite solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1. Preparation of XG / MC composite solution. Add 15 mL of phosphate buffer (10 mmol / L pH 7.4 phosphate buffer + 0.15 mol / L NaCl) into a 50 mL beaker and preheat it in a water bath at 80°C for 5 minutes, then add 2.5 g of methylcellulose ( MC) powder was slowly added to the phosphate buffer at 80°C and kept stirring rapidly. After the methylcellulose powder was completely infiltrated, the solution was cooled to room temperature, and 10 mL of phosphate buffer was added and stirred evenly, and then the solution was transferred to a 4°C refrigerator and continued to stir overnight to fully dissolve the methylcellulose. Add 0.5 g xanthan gum (XG) powder to the above methylcellulose solution, stir rapidly overnight at 4°C to fully dissolve the xanthan gum, then stir gently at 4°C for 24 hours and then centrifuge at low speed to remove the system The bubbles in the xanthan gum / methylcellulose (XG2 / MC10) composite solution were obtained. A series of xanthan gum / methy...

Embodiment 2

[0024] Example 2. Preparation of XG / MC complex solution. Add 15 mL of phosphate buffer solution into a 50 mL beaker and preheat it in a water bath at 80°C for 5 minutes, then slowly add 2.5 g of MC powder into the phosphate buffer solution at 80°C and keep stirring rapidly until the MC powder is completely soaked Cool the solution to room temperature, add 10 mL of phosphate buffer again, then add 0.5 g of XG powder to the above MC dispersion, stir at room temperature until the viscosity of the blended solution is very high, then transfer the solution to a 4°C refrigerator to cool, Then stir at 4°C for 24 hours to fully dissolve XG and MC, and finally remove the air bubbles in the system by low-speed centrifugation to obtain a xanthan gum / methylcellulose (XG2 / MC10) complex solution. A series of XG / MC complex solutions with different concentrations shown in Table 1 can also be prepared by using this method.

Embodiment 3

[0025] Example 3. The injectable properties of XG / MC composite solution and XG / MC composite hydrogel were studied by rotational rheometer. A multi-step thixotropic rate scan was performed on the XG / MC composite solution at 23°C (room temperature condition) and the XG / MC composite hydrogel at 37°C (human body temperature condition) to characterize the thixotropic recovery performance before and after shearing, figure 1 for the experimental results. Among them, the low shear rate (low shear) at room temperature is 0.1 s -1 , hold time is 2 minutes (min), high shear rate (high shear) is 10 s -1 , hold time 1 min; low shear rate 0.5 s at body temperature -1 , with a hold time of 2 min and a high shear rate of 500 s -1 , and the hold time is 1 min. figure 1 The experimental results show that the XG / MC complex solution has high viscosity properties at room temperature and is a hydrogel at body temperature. Both of them have good shear thinning properties and fast recovery pro...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an injectable drug-loaded xanthan gum / methyl cellulose composite hydrogel precursor solution. The drug-loaded xanthan gum / methyl cellulose composite solution comprises 0.5-10 percent by mass volume of xanthan gum and 3-20 percent by mass volume of methyl cellulose, and is a micromolecular medicine or macromolecular medicine. The composite aqueous solution is in a high-viscosity state at room temperature, and has excellent shear thinning and quick restoring injection performances; when the high-viscosity composite aqueous solution is injected into a body, the composite solution shows quick gelatinization performance at 37 DEG C, namely body temperature, and the formed composite hydrogel has excellent mechanical performance, biocompatibility, biodegradability and drug sustained-release effect. The drug-loaded xanthan gum / methyl cellulose composite hydrogel can be widely applied to the field of drug delivery.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an injectable drug-loaded xanthan gum / methylcellulose composite solution with shear thinning and thermal gelation properties and a preparation method thereof. Background technique [0002] Injectable hydrogels have the advantages of simple operation, controllable mechanical properties, filling irregular defects, and non-invasive injection into specific tissues and parts. They have great potential in biomedical fields such as drug delivery, cell encapsulation, and tissue engineering. Wide range of applications. Among them, the hydrogel or high-viscosity gel precursor solution with shear thinning properties is in a low-viscosity fluid state under the action of shear force, and can quickly return to the original hydrogel or high-viscosity fluid when the shearing stops. solution state. This feature makes the shear-thinning injectable hydrogel effectively avoid leakage ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/08A61K47/38
Inventor 姚萍刘志佳
Owner FUDAN UNIV
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