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An ethanol-free mosquito repellent composition capable of enhancing efficacy against menthyl-3,8-diol

A technology of mint base and composition, applied to medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problem of poor retention of anti-mosquito ingredients, unsatisfactory anti-mosquito effects, and poor use effects, etc. problem, to achieve the effect of improving the anti-mosquito effect, reducing the impact, and preventing crystallization

Active Publication Date: 2020-06-09
广州超威生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Menthyl-3,8-diol presents a crystal form at room temperature, and its melting point is higher than that of the skin. Most of the current mosquito repellent products or related patented technologies use relatively high content of alcohol or polyols to solubilize it.
Products that use p-menthyl-3,8-diol as the main anti-mosquito ingredient in the domestic market all use ethanol or ethanol and surfactants to solubilize p-menthyl-3,8-diol. Although it can ensure the uniform dissolution or stable dispersion of menthyl-3,8-diol in the formula, when it is applied on the skin surface, the menthyl-3,8-diol will be precipitated in the form of crystals after the ethanol volatilizes. Mosquito efficiency will be greatly reduced
Domestic patent CN 105816362 A discloses a kind of mosquito repellent lotion for infants and young children. ) solubilization in water-based systems, although alcohol solubilization is not required, the problem with this type of formula system is that it cannot tolerate the washing of skin sweat after being used on the skin surface, and the use of a large number of water-soluble ingredients makes the anti-mosquito ingredients stay on the skin This is why the anti-mosquito effect of menthyl-3,8-diol is still not ideal when using a higher content, and why many products are acceptable under laboratory test conditions, but the actual use effect becomes worse

Method used

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  • An ethanol-free mosquito repellent composition capable of enhancing efficacy against menthyl-3,8-diol
  • An ethanol-free mosquito repellent composition capable of enhancing efficacy against menthyl-3,8-diol
  • An ethanol-free mosquito repellent composition capable of enhancing efficacy against menthyl-3,8-diol

Examples

Experimental program
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Embodiment 1-6

[0058] Examples 1-6 respectively provide an ethanol-free anti-mosquito composition that can improve the effect on menthyl-3,8-diol, and the components contained in the compositions of each example are shown in Table 1 below. The compositions of the examples were made from the ingredients shown in Table 1 . The preparation method can be to first mix the hydrophilic components in the raw materials with water to form a water phase, and mix the lipophilic components to form an oil phase, and then mix the water phase and the oil phase to obtain a mixture that is uniform and uniform. For raw materials including If the formulation of the neutralizing agent is used, the neutralizing agent needs to be added to the mixture and mixed uniformly to obtain the composition.

[0059] The mass percent (wt.%) of each component in the composition of table 1 embodiment 1-6

[0060]

[0061]

[0062] Component definitions in Table 1:

[0063] 1: Polyglyceryl-6 stearate and polyglyceryl-6 b...

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Abstract

The invention relates to the technical field of daily chemical product type mosquito repellents applied to the surface of skin of a human body and particularly relates to an ethanol-free anti-mosquitocomposition capable of improving the effects of p-menthyl-3,8-diol. Selected grease is capable of well dissolving p-menthyl-3,8-diol at the normal temperature, has certain dissolving capacity at a low temperature and can be uniformly spread on the surface of the skin, an added water-resistant film forming agent is capable of generating a synergetic spreading effect and prolonging the standing time of p-menthyl-3,8-diol on the surface of the skin, so that the influences caused by external moisture and moisture in sweat to an anti-mosquito film formed on the surface are reduced, and the anti-mosquito effect is improved; and besides, by adding butanediol, the solubilizing of p-menthyl-3,8-diol can be assisted, so that the separation of crystals is prevented. By conditioning the proportion ofgrease to other components in the composition, the product with a stable system and good skin feel experience can be acquired.

Description

technical field [0001] The invention relates to the technical field of mosquito repellents that can be used on the surface of human skin for daily chemical products, and in particular to prevent the crystallization of p-menthyl-3,8-diol, which can be spread evenly on the surface of the skin to form a film, thereby improving An ethanol-free mosquito repellent composition that has anti-mosquito effects on menthyl-3,8-diol and does not contain ethanol. Background technique [0002] P-menthyl-3,8-diol, referred to as PMD, is an active ingredient of a repellent. It was first discovered from lemon eucalyptus oil and obtained after modification of lemon eucalyptus oil. Menthyl- 3,8-diol is the only natural active ingredient in insect repellents approved for use in the US and Europe. Menthyl-3,8-diol not only has good mosquito repellent effect, but also is effective against ticks. At the same time, its antibacterial and cooling properties make it widely used in the field of daily c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/34A61Q17/02
CPCA61K8/345A61K2800/30A61Q17/02
Inventor 宋银银鹿桂乾张利萍
Owner 广州超威生物科技有限公司
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