Medicament balloon and preparation method thereof

A balloon and drug technology, which is applied in the field of medical devices, can solve the problems of low binding force between drug coating and balloon, effective drug concentration cannot be effectively guaranteed, and low drug transfer rate, so as to increase drug loading, reduce Small drug loss, large specific surface area effect

Active Publication Date: 2014-09-24
深圳市金瑞凯利生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the currently developed drug balloons mainly have the following deficiencies: the drug transfer rate on the surface of the balloon is low due to the existing surface structure of the balloon, and the loss of the drug reaches more than 90% during the delivery and expansion of the balloon. The amount of drug that penetrates into the blood vessel will directly affect the therapeutic effect; in addition, the surface structure of the existing balloon makes the binding force between the drug coating and the balloon low, for example, the drug balloon prepared by drug spraying, the balloon Nearly two-thirds of the drug is lost during wing folding and expansion, and the effective drug concentration cannot be effectively guaranteed

Method used

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  • Medicament balloon and preparation method thereof
  • Medicament balloon and preparation method thereof

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preparation example Construction

[0028] The embodiment of the present invention also provides a preparation method of the drug balloon. Such as figure 1 Shown is a flow chart of the preparation method of the drug balloon in the preferred embodiment of the present invention. The method comprises the steps of:

[0029] Step S01: cleaning the balloon.

[0030] The specific process of cleaning the balloon is as follows: the balloon is ultrasonically cleaned with alcohol, and then ultrasonically cleaned with distilled water. The balloon is dried after 2-3 washes. This application is not limited to this, the time of alcohol ultrasonic cleaning treatment and distilled water ultrasonic cleaning treatment can also be adjusted according to actual production requirements, such as extending or shortening, the order of alcohol cleaning treatment and distilled water cleaning treatment can be changed, or only alcohol can be used. Wash processing step or wash processing step with distilled water only. Since the energy e...

Embodiment 1

[0055] Cleaning the surface of the balloon: ultrasonically clean the balloon with alcohol for 5 minutes, then ultrasonically clean with distilled water for 5 minutes, the ultrasonic frequency of alcohol ultrasonic cleaning and distilled water ultrasonic cleaning is 70Hz, cycle alcohol ultrasonic cleaning and distilled water ultrasonic cleaning Dry the balloon after 2-3 passes. During the ultrasonic cleaning treatment with alcohol and the ultrasonic cleaning treatment with distilled water, keep the temperature of alcohol and distilled water not higher than 36°C. Dry the cleaned balloon and hang it on the jig for later use.

[0056] Etching the surface of the balloon by plasma sputtering: Put the fixture with the balloon in the plasma equipment, and use the bias sputtering method to etch the surface of the balloon by plasma sputtering. The specific process is as follows: when the vacuum degree of the vacuum chamber is 5Pa, oxygen gas with a purity of 99.9% is introduced, and th...

Embodiment 2

[0064]Cleaning the surface of the balloon: ultrasonically clean the balloon with alcohol for 5 minutes, then ultrasonically clean with distilled water for 5 minutes, the ultrasonic frequency of alcohol ultrasonic cleaning and distilled water ultrasonic cleaning is 20Hz, cycle alcohol ultrasonic cleaning and distilled water ultrasonic cleaning The balloon was dried after 2 passes. During the ultrasonic cleaning treatment with alcohol and the ultrasonic cleaning treatment with distilled water, keep the temperature of alcohol and distilled water not higher than 36°C. Dry the cleaned balloon and hang it on the jig for later use.

[0065] Etching the surface of the balloon by plasma sputtering: Put the jig with the balloon in the plasma equipment, and use the DC sputtering method to etch the surface of the balloon by plasma sputtering. The specific process is as follows: when the vacuum degree of the vacuum chamber is 5 Pa, argon gas with a purity of 99.9% is introduced, and the p...

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Abstract

The invention provides a medicament balloon, which comprises a balloon and a medicament coating, wherein the surface of the balloon has a nanometer scale micro-hole structure. The invention further provides a method for preparing the medicament balloon. The method comprises the following steps: performing plasma sputter etching on the surface of the balloon to form the nanometer scale micro-hole structure on the surface of the balloon; preparing the medicament coating on the surface of the balloon. The surface of the balloon has the uniform nanometer scale micro-hole structure, so that the surface of the balloon has a greater specific surface area, and the medicament carrying amount on the surface of the balloon is increased; the physical performance of the balloon is not influenced. According to the preparation method of the medicament balloon provided by the invention, the plasma sputter etching method is adopted, so that the nanometer scale micro-hole structure can be formed on the surface of the balloon, the bonding force between the surface of the balloon and the medicament coating can be improved, and the loss of medicaments in the conveying process of the balloon is reduced.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a drug balloon and a preparation method thereof. Background technique [0002] Intervention (implantation) of devices through minimally invasive technology is one of the main methods for the treatment of cardiovascular diseases. It has the characteristics of small trauma, significant effect, and small side effects. In recent years, this treatment method has achieved rapid development and has changed the traditional treatment. way of coronary heart disease. Minimally invasive interventional techniques have evolved from balloon angioplasty (Percutaneous Transluminal Coronary Angioplasty, PTCA) and metal vascular stent (Bare Metal Stents, BMS) implantation to today's drug-eluting stent (Drug Eluting Stents, DES) implantation. Either due to the problem of the stent itself, or due to the polymer coating of DES, the delayed vascular endothelialization will increase the risk ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61M25/10
Inventor 刘恒全鞠隆艳殷俊光龚元燕珍珍古湖南
Owner 深圳市金瑞凯利生物科技有限公司
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