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Feed additive capable of replacing antibiotics as well as preparation method and application of feed additive

A feed additive, a technology for replacing antibiotics, applied in the application, animal feed, animal feed and other directions, can solve the problems of low volatile oil content, high extraction cost, difficult to apply in large quantities, etc., and achieves high extraction rate, simple method and process, and good activity. Effect

Active Publication Date: 2014-08-27
湖南东方红药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low content of volatile oil in general traditional Chinese medicine and the high cost of extraction, it is difficult to apply in large quantities
Therefore, natural and easily obtained resources are used to extract antibacterial volatile oil, which can be used as antibiotic substitutes and prevention and treatment of animal and poultry diseases. No research has been reported on this aspect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of feed additive that can replace antibiotic, its preparation method is as follows:

[0033] (1) Get camphor leaf 200g, eucalyptus leaf 100g, pine needle 100g, arborvitae leaf 50g and Folium Artemisiae Argyi 50g to be mixed as raw material mixture, carry out supercritical carbon dioxide extraction, obtain mixture extract 35g and residue; The condition of supercritical carbon dioxide extraction is: Extraction pressure 15MPa, extraction time 1h, extraction temperature 35°C;

[0034] (2) Add 350 g of a 10% β-cyclodextrin aqueous solution to the mixture extract, grind for 0.5 h, filter to remove water, and then vacuum-dry to obtain 69 g of the first type product;

[0035] (3) Add 2.5 kg of 85% aqueous ethanol to the residue described in step (1), extract at 60° C. for 2 h, filter, concentrate the filtrate under reduced pressure, and dry in vacuo to obtain 80 g of the second product;

[0036] (4) Mixing the above-mentioned first-type product and the second-type produ...

Embodiment 2

[0038] A kind of feed additive that can replace antibiotic, its preparation method is as follows:

[0039] (1) get camphor leaf 500g, eucalyptus leaf 300g, pine needle 300g, arborvitae leaf 200g and Artemisia argyi 200g to be mixed as raw material mixture, carry out supercritical carbon dioxide extraction, obtain mixture extract 130g and residue; The condition of supercritical carbon dioxide extraction is: The extraction pressure is 30MPa, the extraction time is 3h, and the extraction temperature is 65°C;

[0040] (2) Add 3.9 kg of 30% aqueous solution of β-cyclodextrin to the mixture extract, grind for 2 hours, vacuum-dry after removing water by suction filtration, and obtain 1.29 kg of the first type product;

[0041] (3) Add 22.5 kg of 70% ethanol aqueous solution to the residue described in step (1), extract at 70° C. for 1 h, filter, concentrate the filtrate under reduced pressure, and dry in vacuo to obtain 220 g of the second product;

[0042] (4) Mixing the above-ment...

Embodiment 3

[0044] A kind of feed additive that can replace antibiotic, its preparation method is as follows:

[0045] (1) get camphor leaf 300g, eucalyptus leaf 200g, pine needle 200g, arborvitae leaf 100g and Artemisia argyi 100g to be mixed as raw material mixture, carry out supercritical carbon dioxide extraction, obtain mixture extract 68g and residue; The condition of supercritical carbon dioxide extraction is: The extraction pressure is 20MPa, the extraction time is 2h, and the extraction temperature is 45°C;

[0046] (2) Add 1.36 kg of 20% β-cyclodextrin aqueous solution to the mixture extract, grind for 1 hour, remove water by suction filtration and vacuum dry to obtain 338 g of the first type product;

[0047] (3) Add 9 kg of 60% ethanol aqueous solution to the residue described in step (1), extract at 85° C. for 3 h, filter, concentrate the filtrate under reduced pressure, and dry in vacuo to obtain 105 g of the second product;

[0048] (4) Mixing the above-mentioned first-typ...

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PUM

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Abstract

The invention belongs to the field of an agricultural feed additive, and discloses a feed additive capable of replacing antibiotics as well as a preparation method and the application of the feed additive. The feed additive comprises the following raw material extracts in parts by weight: 20-50 parts of cinnamomum camphora leaves, 10-30 parts of eucalyptus leaves, 10-30 parts of pine needles, 5-20 parts of cacumen biotae and 5-20 parts of folium artemisiae argyi. The preparation method comprises the steps of (1) carrying out supercritical carbon dioxide extraction on the raw material mixture to obtain an extract and residues; (2) mixing the extract with beta-cyclodextrin water solution, grinding, carrying out suction filtration, and carrying out vacuum drying to obtain a first product; (3) extracting the residues by ethanol water solution, filtering, carrying out vacuum concentration, and carrying out vacuum drying to obtain a second product; and (4) evenly mixing the two products to obtain the feed additive. The feed additive can be used for replacing the antibiotics to be added into the animal feed; the add amount of the feed additive is 0.01-0.5%; the feed additive can be used for improving the disease resistance of livestock and poultry and controlling bacteria infection diseases of livestock and poultry.

Description

technical field [0001] The invention belongs to the field of agricultural feed additives, and in particular relates to a feed additive that can replace antibiotics, a preparation method and application thereof. Background technique [0002] The abuse of antibiotics in livestock and poultry farming has become a common phenomenon. The use of a large number of antibiotics not only pollutes the environment, but also induces bacterial resistance, forming a safety hazard. Finding alternatives to antibiotics has become a research hotspot today. [0003] Many Chinese herbal medicines are antibacterial and antibacterial, and are alternative resources for antibiotics. CN101352202A discloses a feed additive that can replace antibiotics in chicken rations, which is composed of extracts of Pulsatilla pulsatillae, purslane, Folium oleracea and folium folium. CN102178066A discloses another compound polysaccharide feed additive that can replace antibiotics in chicken rations, which consi...

Claims

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Application Information

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IPC IPC(8): A23K1/14A23K1/16A23K1/18C11B9/02A23K10/30A23K50/75
CPCY02A40/70
Inventor 叶勇李月
Owner 湖南东方红药业有限公司
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