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Preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic field and temperature dual responsiveness

A technology of isopropylacrylamide and methacrylic acid is applied in the field of preparation of polyporous microspheres, which can solve the problems of poor monodispersity of microspheres and narrow application range, and achieve controlled release of biomedicine and magnetic targeting. The effect of convenient medicine, sensitive temperature responsiveness, and few steps

Inactive Publication Date: 2014-08-13
NORTHWESTERN POLYTECHNICAL UNIV
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Problems solved by technology

[0007] In order to avoid the deficiencies of the prior art, the present invention proposes a preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic responsiveness and temperature sensitivity, which overcomes the preparation of the prior art Polymer microspheres with dual responsiveness to magnetic field and temperature have problems such as poor monodispersity of microspheres and narrow application range

Method used

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  • Preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic field and temperature dual responsiveness
  • Preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic field and temperature dual responsiveness
  • Preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic field and temperature dual responsiveness

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[0023] The technical scheme adopted by the present invention to solve its technical problems: the preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with dual responsiveness to magnetic field and temperature, which is characterized by comprising the following steps.

[0024] (1) Prepare a mixed aqueous solution of N-isopropylacrylamide with a concentration of 6.7-6.8g / L and N,N'-methylenebisacrylamide with a concentration of 0.5-0.8g / L, and add methyl The acrylic acid monomer is added in a proportion of 7.0-9.0% of the weight of the N-isopropylacrylamide monomer in the solution.

[0025] (2) Transfer the solution prepared in step (1) into a three-necked flask and heat it to 70°C under the condition of an oil bath or water bath, and at the same time pass nitrogen into it, and then inject N-isopropylacrylamide into the solution with a mass of 2.3~ 3.0% of the initiator, started to initiate the polymerization reaction.

[0026] (3) The initiat...

Embodiment 1

[0033] Example 1: Add 0.3397g of N-isopropylacrylamide and 0.0251g of N,N'-methylenebisacrylamide into 50mL of pure water, and add 25μL of methacrylic acid to it after fully dissolving. Pour the mixed solution into a 100mL three-neck flask, place it in an oil bath at 70°C for magnetic stirring, and at the same time pass through nitrogen gas. After 20 minutes, add 3 mL of ammonium persulfate aqueous solution with a concentration of 2.5 mg / mL to the solution with a syringe, and wait for 3 to 5 minutes. The solution appeared light blue, and the nitrogen reaction was continued for 12h. After the reaction, stir and cool to room temperature, adjust the pH value of the solution to 10.00 with 1:1 diluted ammonia water under pH meter monitoring and magnetic stirring, stir at room temperature for 4h, then use 1:1 under pH meter monitoring and magnetic stirring 1 diluted hydrochloric acid to adjust the pH value of the solution to 2.50, sealed and stirred for 4h. Then put the sample into...

Embodiment 2

[0036] Example 2: Add 0.7000g of N-isopropylacrylamide and 0.0800g of N,N'-methylenebisacrylamide into 100mL of pure water, and add 52μL of methacrylic acid to it after fully dissolving Pour the mixed solution into a 250mL three-neck flask, place it in an oil bath at 70°C for magnetic stirring, and at the same time pass through nitrogen gas. After 20 minutes, add 6 mL of ammonium persulfate aqueous solution with a concentration of 3 mg / mL to the solution with a syringe, and wait for 3 to 5 minutes. Appear light blue, continue nitrogen reaction 10h. After the reaction is over, stir and cool to room temperature, adjust the pH value of the solution to 9.90 with 1:1 diluted ammonia water under pH meter monitoring and magnetic stirring, stir at room temperature for 3h, then use 1:1 under pH meter monitoring and magnetic stirring 1 diluted hydrochloric acid to adjust the pH value of the solution to 2.00, sealed and stirred for 3h. Then put the sample into a dialysis bag with a mole...

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Abstract

The invention relates to a preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic responsiveness and temperature sensibility. The preparation method comprises the following steps: firstly, preparing polymeric porous microspheres with the temperature sensibility by using an alkali-acid step-by-step treatment method, and then forming Fe3O4 nanoparticles in situ on the surfaces of the porous microspheres and in pore channels of the porous microspheres by using a coprecipitation method. The preparation method has the beneficial effects that the polymerization process is completed in one pot, and the aftertreatment process is relatively simple. A poly(N-isopropylacrylamide) skeleton is capable of providing temperature sensibility for a compound system; the Fe3O4 nanoparticles formed in situ on the surfaces of the polymeric porous microspheres and in the pore channels of the polymeric porous microspheres are capable of providing good superparamagnetism for the polymeric microspheres; and porous structures in the polymeric microspheres are capable of providing convenient conditions for applications of the polymeric porous microspheres in terms of biological medicine controlled release and magnetic targeting drug delivery.

Description

technical field [0001] The invention relates to the field of functional polymer materials, and relates to a preparation method of poly(N-isopropylacrylamide-methacrylic acid) porous microspheres with magnetic response and temperature sensitivity. Background technique [0002] In recent years, polymer porous microspheres with environmental responsiveness have been widely used in many fields, such as: chemistry, cytology, environmental engineering, biotechnology and biomedical engineering, etc. Therefore, the development of new polymer porous microspheres method is particularly important. [0003] Document 1 "Jiguang Zhang, Shengqing Xu, and Eugenia Kumacheva. Polymer Microgels: Reactors for Semiconductor, Metal, and Magnetic Nanoparticles. Journal of the American Chemical Society. 2004, 126, 7908-7914" discloses a microcoagulation of polymer Glue is used as a template to synthesize magnetic nanoparticles. The method is to first synthesize poly(N-isopropylacrylamide-acrylic a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08F220/54C08F222/38C08F220/06C08K3/22
Inventor 田威王娇张卫红
Owner NORTHWESTERN POLYTECHNICAL UNIV
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